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Biomedical subjects

C H Fox

Publications and source records attributed to C H Fox.

At least 91 records · Page 5Linked to original sources
PubMed1989

Detection of human immunodeficiency virus-1 by 35S-RNA in situ hybridization in solitary esophageal ulcers in two patients with the acquired immune deficiency syndrome.

Esophageal disease frequently complicates the course of the acquire immune deficiency syndrome. In two patients with unusual refractory esophageal ulcers, we were able to demonstrate the presence of human immunodeficiency virus RNA in lymphocytes and mononuclear cells from the ulcer base, using an in situ hybridization technique. These observations suggest that human immunodeficiency virus may play a role in the development or persistence of solitary refractory esophageal ulcers.

Acquired Immunodeficiency Syndrome↗
PubMed1984

John Shaw Billings.

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History, 19th Century↗
PubMed1984

Papanicolaou smear screening and cervical cancer. What can you expect?

More than 90% of the total female population of three Swedish counties between the ages of 30 and 59 years, 53% of women between 60 and 69 years, and 25% of women older than 70 years were screened for cervical cancer with the Papanicolaou smear over a ten-year period. The uniqueness of the study is that in Sweden it is possible to follow up the entire population during their lifetimes via a population register, which has its roots in the 17th century, natural to Swedes but almost incomprehensible in the United States or United Kingdom. Every Papanicolaou smear taken was computer recorded and linked on an individual level to the cancer registry. There were 207,455 women followed up for ten years. No women were lost to follow-up. There was a 75% decrease in invasive cervical cancer incidence among women who had smears taken at least once during the ten-year period. Among those women who had never had smears taken, the incidence of invasive cervical cancer was four times as great as among those women who had been examined at least once. We estimate that the system proposed by Swedish Medical Board (at least one smear every three years) for cervical cancer screening can reduce the incidence of invasive cervical cancer to a level between one and five cases per 100,000 women per year in a completely screened population.

Adult↗
PubMed1983

Predicting the outcome of endometrial hyperplasia by quantitative analysis of nuclear features using a linear discriminant function.

Nuclear parameters from 24 cases of atypical endometrial hyperplasia were determined by means of graphic tablet and microcomputer. Eight of the 24 hyperplasias progressed to carcinoma, but the remaining 16 did not progress during a mean follow-up period of 11.8 years. A linear discriminant function selected the mean and standard deviation of maximal nuclear diameter as useful predictors of clinical outcome. The linear discriminant function predicted the correct outcome in 83% of the cases. This study suggests that measurement of nuclear parameters in atypical endometrial hyperplasia may provide a more objective means of predicting the behavior of the various forms of hyperplasia.

Cell Nucleus↗
PubMed1980

Adhesion of metastatic and non-metastatic carcinoma cells to glass surfaces.

Adhesion in vitro is described in cells from a tumor pair originating from a single methylcholanthrene-induced mouse carcinoma. One member of this tumor pair shows a high incidence of metastases while the other does not metastasize. Cells from the non-metastasizing carcinoma were found to form close and focal contacts with a glass substrate consecutively, as do normal mouse kidney epithelial cells. Cells from the metastasizing carcinoma, however, had only limited areas of close contact and generally failed to form focal contacts. It is suggested that this alteration in cell-substrate adhesion contributes to the release and mobility of metastatic cells.

Animals↗
PubMed1980

Teaching medical English to foreign-language doctors.

Acquisition of an advanced medical degree beyond licensure and specialization is advantageous and encouraged in Swedish medical education. Since a thesis and a number of published works, usually in English are required, there is considerable interest in medical writing by doctors and medical scientists. A voluntary course in 'Biomedical Authorship' which included presentation of oral reports was offered by the Karolinska Institutes' Medical Faculty. This course was intended to prepare participants for their thesis work and for presentations at scientific congresses. The course revealed that the principle difficulty was not in English skills which were rather good, but in the students' inexperience in critically rereading what they had written and making suitable revisions. A case study method was used so that students acquired experience in critically reading and correcting their own work and that of others. An instructor who understood the evolution of academic Swedish was of considerable help in explaining some of the 'Swenglishisms' that arose during the course. The oral presentation portion, which used videotapes of students, showed the students as lacking experience in basic public speaking and as frequently being apprehensive. This was much improved by taped poetry readings, scientific reports and slide shows. This Swedish experience should apply to teaching biomedical writing in the other Scandinavian countries and in Northern Europe.

Authorship↗
PubMed1979

Innovation in medical diagnosis--the Scandinavian curiosity.

Fine-needle aspiration biopsy is a major diagnostic tool in Scandinavia, where 8000 such biopsies may be done in a large metropolitan hospital each year. The procedure is rapid, inexpensive, and technologically simple, yet it has found only limited, albeit increasing, acceptance in medical practice outside Scandinavia. Although the differences between Scandinavian and other medical systems may explain why the technique is not used more widely, there seems to be an underlying reluctance among medical communities to accept subjective types of innovation compared with objective innovation.

Biopsy, Needle↗
PubMed1979

Medical exchanges.

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Foreign Medical Graduates↗