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Biomedical subjects

C H Chu

Publications and source records attributed to C H Chu.

3 recordsLinked to original sources

Nonlinear methods in electrocardiogram signal processing.

Electrocardiographic (ECG) signals are frequently corrupted by impulsive noise due to muscle activities, and background normalization is often needed to correct for patient motion and respiration. Nonlinear signal processing methods are effective alternatives to conventional linear filtering methods when dealing with impulsive noise or noise types that are difficult to characterize. The class of nonlinear filtering methods studied in this article operate by moving a window of finite width along the input data sequence. At each position, the filter output is obtained from the input samples inside the window. Nonlinear operators differ from linear filters in that the output is not a simple linear combination of the input samples. Three classes of nonlinear operators--median filters, morphologic operators, and the alpha-trimmed mean filter--are briefly introduced and algorithms using them for ECG signal processing are presented. Empirical results indicate that the nonlinear operators are good candidates for impulsive noise suppression and background normalization in ECG signal processing.

Algorithms

The 3-hydroxyacyl-CoA epimerase activity of rat liver peroxisomes is due to the combined actions of two enoyl-CoA hydratases: a revision of the epimerase-dependent pathway of unsaturated fatty acid oxidation.

Chromatography of a rat liver extract on DEAE-cellulose resulted in the near total loss of 3-hydroxyacyl-CoA epimerase activity. The activity was regained either when fractions were recombined or when purified crotonase was added to the early column fractions. A new enoyl-CoA hydratase present in these early fractions catalyzes the conversion of D-3-hydroxyacyl-CoA to 2-trans-enoyl-CoA which can be hydrated by crotonase or the peroxisomal bifunctional enzyme to L-3-hydroxyacyl-CoA. Thus, the 3-hydroxyacyl-CoA epimerase activity is due to the combined actions of two enoyl-CoA hydratases with opposite stereospecificities.

Animals

Impulsive noise suppression and background normalization of electrocardiogram signals using morphological operators.

A new approach to impulsive noise suppression and background normalization of digitized electrocardiogram signals is presented using mathematical morphological operators that incorporate the shape information of a signal. A brief introduction to these nonlinear signal processing operators, as well as a detailed description of the new algorithm, is presented. Empirical results show that the new algorithm has good performance in impulsive noise suppression and background normalization.

Algorithms