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Biomedical subjects

C H Bastomsky

Publications and source records attributed to C H Bastomsky.

36 records · Page 2Linked to original sources
PubMed1975

On the mechanism of polychlorinated biphenyl-induced hypobilirubinaemia.

Treatment of normal rats with a polychlorinated biphenyl mixture of DDT increased liver microsomal protein concentration. Hepatic microsomal bilirubin UDP-glucuronyltransferase activity was elevated in the DDT-treated, but not in the polychlorinated biphenyl-treated rats. In contrast polychlorinated biphenyl, but not DDT, reduced serum bilirubin concentrations in jaundiced Gunn rats, as did sulphadiazine; sulphonamides compete with bilirubin for binding sites on plasma albumin. Polychlorinated biphenyls appear to lower serum bilirubin concentration by reducing the binding of bilirubin to plasma protein.

Animals↗
PubMed1975

Enhanced thyroxine metabolism following cutaneous application of microscope immersion oil.

Microscope immersion oil, applied to the skin of rats or injected intraperitoneally, led to a substantial increase in the biliary excretion of intravenously injected 125-I-thyroxine (T4), elevated the bile: plasma 125-I ratio, enhanced the biliary clearance rate of plasma 125-I-T-4 and increased the proportion of biliary 125-I present as T-4-glucuronide. Immersion oil applied to the skin was at least as effective as injected intraperitoneally. Skin application also elevated bile flow, liver weight, thyroid 131-I uptake and Sephadex uptake of serum 125-I-triiodothyronine (indicating reduced binding of thyroid hormone to serum proteins) and depressed serum T-4 concentrations. These effects were similar to those previously observed after intraperitoneal injection of a polychlorinated biphenyl mixture.

Administration, Topical↗