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Biomedical subjects

C Guillot

Publications and source records attributed to C Guillot.

77 records · Page 5Linked to original sources
PubMedDate not supplied

[The hyperammonemia of exercise; value of automatic measurement].

Ammonia blood level (NH3) was measured during maximum exercise performed on cycloergometer, in 11 patients. NH3 measurements through an automatic chemical method (whole blood) were compared to those of the enzymatic reference method (plasma). Automatic analysis made it possible to quickly obtain [NH3] values, that were highly correlated with those of the enzymatic method (P < 0.001). Plasma [NH3] may be calculated from the following equation, where it is expressed versus [NH3] obtained with the automatic method (c anal): [NH3] mumol.l-1 = 0.795. [c] anal.microgram.dl-1 + 5.446.

Ammonia↗
PubMedDate not supplied

Increased ventilatory chemosensitivity induced by domperidone, a dopamine antagonist, in healthy humans.

Respiratory and cardiovascular effects of domperidone (0.1 mg X kg-1 i.v.) and placebo given on separate test days to eleven healthy volunteers were assessed in a double-blind study. Domperidone caused no significant change in ventilation, heart rate and blood pressure while they were resting and breathing room air. However, it produced an increase in the slope of the hypoxia-induced ventilatory response, from 2.35 +/- 1.10 to 3.71 +/- 2.91 1 X min-1 per 1% decrease in SaO2 (mean +/- SD; p less than 0.05). We conclude that domperidone augments hypoxic responsiveness in humans, presumably by blocking the dopaminergic receptors that modulate the activity of carotid body chemoreceptors, as it does not readily cross the blood-brain barrier.

Adult↗