Biomedical subjects

C Griscelli

Publications and source records attributed to C Griscelli.

365 records · Page 21Linked to original sources

PubMedDate not supplied

[Disturbances of chemotaxis in protein-calorie malnutrition (author's transl)].

A study of specific and non-specific immune functions was performed in 14 children presenting with severe malnutrition, before and after parenteral hyperalimentation by central catheter. Anomalies of cellular functions (reduction of the percentage of E rosettes and deficient proliferation with mitogens) were rarely found. Measurements for serum immunoglobulins did not show any anomaly; however reduced percentages of EAC rosettes and important increase in "null" cells were found in about one third of the cases. The main finding was a decreased serum chemotactic activity following activation of the classic complement pathway. This was found in 12 children and returned to normal values in all cases after hyperalimentation.

Chemotactic Factors↗

PubMedDate not supplied

[Susceptibility to infections and hyper IgE: 19 new case reports ].

Nineteen patients exhibiting a susceptibility to infections due to staphylococcus and fungi, allergy and hyper IgE are reported (syndrome described by R. Buckley). Prognathism, coarse features and marked osteoporosis were observed in more than half the patients. Immune disorders were characterized by a defective chemotaxis of granulocytes and depressed in vivo and in vitro immune responses to antigens. These cellular abnormalities could be secondary to a dysregulation of IgE synthesis resulting in an excess of secretion of histamine, heparin and other substances from mast cells. According to this possible mechanism, we suggest a therapy associating anti-histaminic substances which block H1 and H2 receptors and an agent which inhibits mast cell degranulation.

Adolescent↗

PubMedDate not supplied

[Chronic neutropenia and Crohn's disease in childhood. Report of 2 cases ].

Two children in whom Crohn's disease complicated the course of chronic neutropenia are reported. These two cases had other features in common: consanguinity of the parents, relatively good clinical tolerance of neutropenia and almost complete lack of blood and marrow eosinophils. The possible relationships between the 2 diseases are discussed.

Adolescent↗

PubMedDate not supplied

[Role of the classical and alternative complement pathways in chemotaxis of human C2 deficiency (author's transl)].

The roles of the classical and alternative complement pathways in the formation of chemotactic factors were comparatively evaluated in a normal serum and a serum from a child with congenital C2 deficiency. Neutrophil chemotactic index was determined by a direct microscopic observation using serum activated by an immune complex for the classical pathway, and by zymosan A or liposaccharide of Salmonella enteritidis for the alternative pathway. Chemotactic activity was observed only when the C2-deficient serum was activited by the alternative pathway in the presence of zymosan A. But, in comparison to normal serum, the chemotactic activity of C2-deficient serum was impaired by dilution or short incubation time. Addition of purified C2 resulted in the normalisation of chemotactic activity induced by activation of classical and alternative pathways. These results suggest that integrity of the classical pathway of the complement is necessary for the optimal formation of the chemotactic mediators induced by the alternative complement pathway. The implications of the alternative complement pathway alteration with regard to susceptibility to bacterial infections, are discussed.

Antigen-Antibody Complex↗

PubMedDate not supplied

[Action of isoprinosine on the "in vitro" activation of human lymphocytes (author's transl)].

The action of isoprinosine on lymphocytes stimulated by optimal or suboptimal concentrations of polyclonal mitogens (ConA and PWM) was studied in 3, 5 and 7-days cultures. In some experiments, varying concentrations of isoprinosine were added to lymphocyte cultures at variuos times. Isoprinosine exerted no effect on non stimulated cells but enhanced the proliferative response in the presence of mitogens. The optimal response was obtained with a dose of 1 000 micrograms (/10(6) cells) of isoprinosine and on the 5th day in the cultures stimulated by ConA or PWM, but an enhancing effect could still be detected on the 7th day of culture. The effect seems stronger when isoprinosine is introduced earlier in the course of the cultures. Preliminary experiments suggest that isoprinosine increase the proliferation of both T and B cells and that its activity on B cells could be due to the potentiating action of helper T cells.

B-Lymphocytes↗