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Biomedical subjects

C Green

Publications and source records attributed to C Green.

At least 199 records · Page 11Linked to original sources
PubMed1991

Longitudinal study of inmates of a prison for the psychiatrically disturbed: plasma concentrations of biogenic amine metabolites and amino acids.

Plasma concentrations of eight large and neutral amino acids and 10 acidic metabolites of biogenic amines in seven inmates incarcerated in the Regional Psychiatric Centre (Praries), Correctional Service of Canada, were assessed each week day for 4 weeks (i.e., 20 samples each). Measures of central tendency and dispersion of the variables were calculated. The measures are distinctively different in their variability and their normality of distribution. The large and neutral amino acid (LNAA) measures are somewhat less variable, but also less likely to be normally distributed than most acid metabolites. Acid metabolites tend to show consistent interindividual differences that persist over time, with the notable exception of 5-hydroxyindoleacetic acid. LNAA measures tend to show differences across time but not between individuals. The distributional properties of LNAA measures are largely accounted for by the observation of a downward convergence of values of these variables over the 4 weeks of the study.

Adult↗
PubMed1991

Miltenberger class IX of the MNS blood group system.

Mi.IX is a new phenotype in the Miltenberger series of the MNS blood group system with a frequency of 0.43% in Denmark. Mi.IX red cells are Mur+ but do not express any of the other established Miltenberger determinants. They react with a new antibody, anti-DANE, which defines a determinant present on Mi.IX cells but not on cells of other Miltenberger phenotypes. Four Mi.IX propositi have been found. Their families show that MiIX is inherited with a MS complex (lod score 3.69 at theta = 0.00) which produces a trypsin-resistant M antigen. DANE has been allotted the ISBT number 002032 (MNS32). Serological and immunochemical studies with human and monoclonal antibodies to various determinants on glycophorin A (GPA) suggest that Mi.IX is associated with an aberrant GPA molecule that lacks the trypsin cleavage site at amino-acid residue 39, retains the chymotrypsin cleavage site at residue 34 and has an apparent Mr of about 1,000 less than normal GPA. It is proposed that this Mi.IX molecule has an amino acid and possibly also a glycosylation change in the region of amino-acid residues 35-39.

Adult↗
PubMed1991

A case of hepatitis related to etretinate therapy and hepatitis B vaccine.

The case of a 41-year-old male patient is described who developed acute reversible hepatitis related to etretinate therapy. During the course of etretinate he received 2 doses of hepatitis B vaccine; this and his HLA typing A1, A2, Bw57, Cw6 may have predisposed him to develop this reaction.

Acute Disease↗
PubMed1991

Evaluation of systolic and diastolic heart function.

The evaluation of cardiac function generated considerable interest in the 1990 literature. Conventional modalities such as contrast angiography, cardiac ultrasound, and radionuclide angiography are being applied in new ways to the investigation of both systolic and, especially, diastolic heart function. Ultrafast CT can be used to precisely quantitate ventricular volumes and ejection fraction. Similarly, spin-echo and cine MR imaging provide accurate estimates of both global and regional ventricular function. However, the high cost of these sophisticated imaging modalities may limit their use for the routine assessment of systolic heart function.

Diagnostic Imaging↗
PubMed1990

Intracellular iron redistribution. An important determinant of reperfusion damage to rabbit kidneys.

These studies were designed to examine the possible role of low molecular weight intracellular iron chelates (desferrioxamine-available (DFX-A) iron) in the damage which occurs during cold storage and subsequent reperfusion of kidneys. The level of DFX-A iron increased significantly (P less than 0.005) in the cortex of rabbit kidneys rendered cold ischaemic (CI) for 24 hr and the amount of iron available for DFX chelation increased significantly (P less than 0.05) in both the cortex and medulla of kidneys stored for 48 or 72 hr compared with fresh non-ischaemic controls. During ex vivo reperfusion of the organs with an oxygenated asanguinous perfusate, DFX-A iron returned rapidly to pre-ischaemic levels in 24 hr CI kidneys, but remained elevated following 48 and 72 hr CI (P less than 0.05 compared with 24 hr CI kidneys after 5 min reperfusion), returning to control levels only after 30 min reperfusion. There was no concurrent increase in total iron levels, indicating that a redistribution of iron to more accessible pools had occurred within the tissue. We suggest that decompartmentalization of intracellular iron during ischaemia and raised DFX-A iron levels over an extended period during subsequent reperfusion are responsible for increased catalysis of oxygen-derived free radical-mediated lipid peroxidation, and are an important factor in the deterioration of physiological function observed in rabbit kidneys following extended periods of cold storage.

Animals↗
PubMed1990

A low-incidence red cell antigen JAL associated with two unusual Rh gene complexes.

A multilaboratory investigation during several years has identified a low incidence antigen JAL on the red cells of 7 propositi. JAL appears to be associated with two unusual Rh complexes, one of which produces a depressed C antigen and the other a depressed c antigen. Family studies strongly suggest that the JAL antigen is encoded by the RH locus. Anti-JAL has been implicated in haemolytic disease of the newborn and is thus considered to be a clinically significant antibody.

Female↗
PubMed1990

Have we the skills?

Making care more personal for patients demands that sound assessments of their needs and abilities are made in the first case. In this paper, it is argued that the assessment skills of nurses are lacking in settings where both patients and staff have become institutionalised. Breaking this mould can be achieved in a variety of ways, and here a brief description is given of how a new assessment tool and the support of a clinical specialist team can effect changes in patients' abilities and staff behaviour.

Aged↗
PubMed1990

Waking dreams and other metachoric experiences.

This paper summarizes the development of the concept of metachoric experiences from 1961 onwards. The name of metachoric experience was given to one in which the whole of the environment was replaced by a hallucinatory one, although this may provide a precise replica of the physical world and appear to be completely continuous with normal experience. Prior to 1968 three types of metachoric experiences had been recognized; lucid dreams, out-of-the-body experiences (OBEs) and false awakenings, all of which showed interrelationships. The Institute's 1968 appeal for apparitional experiences led to a recognition that many of these were probably metachoric. This was suggested among other things by certain cases in which the lighting of the whole field of view changes, thus indicating that the experience was completely hallucinatory. The study of apparitions led also to the concept of waking dreams, i.e. completely hallucinatory experiences which may be initiated and terminated without any awareness of discontinuity on the part of the subject. These experiences seem to be capable of considerable apparent extension in time, thus providing a possible explanation of some reports of UFO sightings and of some of the more anomalous experiences of psychical research. In this connection the paper discusses the well-known Versailles experience of Miss Moberly and Miss Jourdain, and a published case of C.G. Jung. In conclusion some of the most obvious similarities and differences between the different types of metachoric experiences are discussed.

Awareness↗
PubMed1989

Germline transmission of exogenous genes in the chicken.

Difficulties associated with in vitro manipulation and culture of the early chicken embryo have restricted generation of transgenic chickens to approaches that use replication-competent retroviruses. The need to produce transgenic chickens in the absence of replicating virus prompted development of a new method of gene transfer into the chicken. Microinjection of the replication-defective reticuloendotheliosis virus (REV) vector ME111 beneath unincubated chicken embryo blastoderms results in infection of germline stem cells. This vector contains genetic information exogenous to the chicken genome, including both the herpes simplex virus type 1 thymidine kinase gene and the Tn5 neomycin phosphotransferase gene. About 8 percent of male birds hatched from injected embryos contained vector DNA in their semen. All four positive males tested passed vector sequences onto their progeny. Analysis of G1 offspring showed that gonads of G0 male birds were mosaic with respect to insertion of vector provirus. Thus, primordial germ cells present in the unincubated chicken embryo blastoderm are susceptible to infection by defective REV vectors.

Animals↗
PubMed1989

Dissociation of ST segment elevation and regional wall motion with open-artery, intracoronary Fluosol.

Intracoronary infusion of oxygenated Fluosol during percutaneous transluminal coronary angioplasty has been shown to reduce chest pain and preserve contractile function. In spite of this evidence for reduced severity of myocardial ischemia, ST elevation is frequently observed on the electrocardiogram. To determine if Fluosol produces ST segment elevation by a mechanism other than myocardial ischemia, closed-chest dogs underwent three interventions: (1) an infusion of oxygenated Fluosol into the unoccluded left anterior descending (LAD) coronary artery; (2) an identical infusion of unoxygenated Ringer's lactate; and (3) a transient occlusion of the LAD coronary artery. Open-artery infusions were chosen to minimize ischemia by permitting antegrade coronary blood flow. ST segments were monitored continuously and contrast left ventriculography was performed to assess regional systolic function. Coronary occlusion for 1 minute resulted in significant ST segment elevation from baseline (0.8 +/- 0.2 to 3.2 +/- 0.6 mm, p less than 0.05) and marked depression in regional ejection fraction (45 +/- 7% to -3 +/- 4%, p less than 0.05). Infusion of Fluosol produced a similar degree of ST segment elevation (0.9 +/- 0.3 to 2.8 +/- 0.4 mm, p less than 0.05), but no change in regional ejection fraction. Ringer's lactate infusion also resulted in ST segment elevation associated with preservation of regional contractility. Because regional systolic function (a sensitive indicator of regional ischemia) was preserved and an open-artery infusion was used, it is concluded that intracoronary infusion of Fluosol causes ST segment elevation by a mechanism other than myocardial ischemia.(ABSTRACT TRUNCATED AT 250 WORDS)

Angioplasty, Balloon↗