Biomedical subjects

C Gras

Publications and source records attributed to C Gras.

70 records · Page 4Linked to original sources

PubMedDate not supplied

[Management of an isolated thyroid nodule or a heterogeneous nodular goiter, when thyroid scintigraphy is not available (Tahiti)].

Thyroidal nodes (non-cystic) always put forward some difficult decision. As a matter of fact, it would not be reasonable to undergo each time a surgical operation, but it would be catastrophic to abstain wrongly. When scintigraphy and mainly cyto-puncture are feasible, so a coherent decision can be taken. When they are not possible and when only ultrasonography is available, we propose that a decision be taken according to a comprehensive approach although each argument being individually disputable.

Biopsy↗

PubMedDate not supplied

Long-term use of an LH-RH agonist in the management of uterine leiomyomas: a study of 17 cases.

Seventeen nonmenopausal women with symptomatic uterine myomas, diagnosed by clinical examination and confirmed by pelvic ultrasonography, were treated with a delayed-release microcapsule preparation of D-Trp-6-LH-RH (Decapeptyl) injected intramuscularly, every 28 days. The microcapsules were designed to release 100 micrograms/day for 30 days. The mean duration of treatment was 4.7 months (range, 1-11). In all patients, the pituitary-ovarian axis was suppressed after 1 month of treatment, and mean serum estradiol levels fell to 17.3 pg/mL (range, 5-80). There were no significant changes in serum LH and FSH levels. Fifteen patients (83%) experienced an improvement of such symptoms as abdominal pain and bleeding. Enlarged uteri decreased in 81% of patients during the treatment, and in 38% of them the decrease in uterine volume was more than 50%. Among the 12 myomas found in 10 women, 2 disappeared and 9 decreased in volume during the treatment; for 7 myomas the decrease was more than 50%. After Decapeptyl, eight patients did not require any additional therapy, four underwent surgery, and the others were treated with progestins. The side effects were mild, consisting mainly of hot flushes. Our findings suggest that Decapeptyl may be useful for the treatment of uterine myomas.

Administration, Oral↗

PubMedDate not supplied

[The human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) in New Caledonia].

The authors report on 15 HIV seropositive cases detected within 2 years in New Caledonia (150,000 inhabitants). Testing HIV antibodies was systematic among blood donors (9,917 persons) and was carried out in defined samples (1,475 persons): population at risk, rural area, and tests required by clinicians. All seropositive individuals belong to "high risk group". One certain AIDS case, group IV C (as defined by CDC Atlanta), another probable one (early death) and several opportunistic infections: herpes zoster, oral and candidosis, were observed. Biological exploration is quite good (Pasteur Institute in Noumea). However, therapy is problematic in this South Pacific Island, and management of seropositive patients is difficult.

AIDS Serodiagnosis↗

PubMedDate not supplied

[A case of ureteral bilharziasis followed for 22 years].

The authors report on one case of urinary schistosomiasis monitored for 22 years. It illustrated the problems posed by the "bilharzial uretero-hydronephrosis". They analyse the different therapy problems which have to have been successively solved: Low double ureteral stenosis. The difficulty to be certain of such a stenosis is recalled. The possibility of a reflux or an ureteral atony must be eliminated. True stenosis must be operated without delay; Kidney cancer revealed 20 years later through chronic renal failure by vesico-ureteric reflux caused by the first surgical intervention (latero-lateral vesico-ureteric anastomosis); Iatrogenic vesico-ureteral reflux, treated by uretero-vesical implantation on "psoic" bladder with anti-reflux submucous path. The future of such a chronic renal failure is linked to the capability of the remaining ureter to ensure an acceptable passage of urine, and to the rehabilitation possibility of the kidney. Finally, the authors recalled the difficult therapeutic indications in case of ureteral attack due to bilharziosis.

Follow-Up Studies↗

PubMedDate not supplied

[Relapse of an amebic abscess of the liver after treatment with metronidazole].

The authors report the observation of a twenty four years old soldier; subsequent to a stay in an endemic amoebic area, he showed several successive dysenteric episodes which were treated with metronidazole despite the absence of amoeba in the coprological examination. During one of these episodes, he presented a single rectal ulceration, then a hepatic abscess was observed four months later. The patient was treated with metronidazole and by contact amoebicides. In spite of that, amoeba were disclosed after a parasitological stool examination.

Adult↗

PubMedDate not supplied

[Risk of AIDS for the occasional traveler in Africa].

The authors first point out the importance of A.I.D.S. in Africa; then they appreciate the risk of contamination for occasional traveller in Africa. They recall some epidemic features of tropical A.I.D.S., its originality suggesting some risk factors different from the ones faced in temperate countries. Importance of risk of heterosexual transmission is emphasized, as well as possible parenteral contamination in connection with the frequent use of disposable needles and syringes again utilized without preliminary sterilization. Taking into consideration all these possibilities, the authors expose some prophylactic advises intended for people travelling briefly in endemic zones.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

[Therapy of deep mycoses].

In 1985, available drugs to cure deep mycosis are in fact limited to amphotericin B (Fungizone), 5-fluorocytosine (Ancotil) and ketoconazole (Nizoral). Potassium iodide is not much utilized. In diffuse aspergillosis and meningitic cryptococcosis, Fungizone by I.V. injection remains the high-grade antifungal drug--Ancotil is not actually used anymore in mono-therapy, but associated either with Fungizone in cryptococcosis and diffuse aspergillosis, or with Nizoral in systemic candidosis--Nizoral, which does not diffuse in C.S.F. and has a limited efficiency in immunosuppressive patients, is recommended in systemic candidosis and tropical deep mycosis, particularly histoplasmosis, blastomycosis, entomophtoromycosis, as well as in candidosis and diffuse aspergillosis prophylaxis in people at high risk. New antimycosis drugs are under studies: itraconazole efficient against aspergillus and fluconazole, which diffuses in C.S.F. and has a long time action.

Adult↗

PubMedDate not supplied