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Biomedical subjects

C Grant

Publications and source records attributed to C Grant.

At least 127 records · Page 7Linked to original sources
PubMed1989

[Metabolic studies in 2 cases of chondrocalcinosis with hypomagnesemia].

Two cases of chondrocalcinosis associated with hypomagnesemia are presented and a literature review is carried out, revealing that half of the reported cases are associated with Bartter Syndrome. We describe the metabolic studies performed and discuss the possible role of calciotrope hormones in this type of clinical manifestation. The pathogenesis is thought to be a defect in the transport across the renal tubular cell (and also, possibly an alteration in the intestinal epithelial membrane) as well as the presence of other metabolic alterations (hypocalcemia, hypokalemia, hydrocarbon intolerance) associated with this not so rare disease.

Adult↗
PubMed1988

Characterization of an unusual cAMP receptor and its related polypeptides in Dictyostelium discoideum.

Several lines of evidence indicate that cAMP modulates developmental gene activity via cell-surface receptors. We describe here a novel cAMP receptor, CABP1, whose properties are consistent with the idea that this protein is involved in gene regulation. Firstly, immunological techniques using anti-CABP1 antibodies as probes showed that this cAMP receptor can be detected on the surface of developing cells. Secondly, there is a steady migration of CABP1 to the nucleus during development. Thirdly, some genetic variants exhibiting an altered pattern of development are found to possess modified CABP1. We also showed that CABP1 co-purifies with at least seven other polypeptides which share common epitopes with CABP1. Interestingly, four of the CABP1-related polypeptides can be detected on the cell surface as well as in the nucleus.

Dictyostelium↗
PubMed1988

Immunohistochemical monitoring of metastatic colorectal carcinoma in patients treated with monoclonal antibodies (MAb 17-1A).

A therapeutic trial using repeated doses of a mouse monoclonal antibody against the tumor-associated antigen (TAA) CO17-1A in metastatic colorectal carcinomas was carried out. Metastatic lesions sampled by repeated thick needle (1.2 mm) biopsies during therapy were examined immunohistochemically for the presence of various TAAs, mouse IgG, complement, and infiltrating leukocytes. The CO17-1A was consistently expressed in all cases along the basement membrane of tumor glands and could only be demonstrated on cryostat sections whereas the TAAs GICA19-9, GA73-3, and Br55-2 were also visualized in B5-fixed paraffin-embedded biopsies. The CO17-1A and GA73-3 were predominantly present at the basal region in contrast to the GICA 19-9 and Br55-2 which were predominant at the luminal and the apical region of the tumor glands. Antigenic modulation was not seen either after 24-72 h or during prolonged treatment. In all cases the infused mouse IgG was detected, from 24 h after infusion up to 6-8 weeks, mainly along the basal region of tumor glands. In 13/14 posttreatment biopsies, complement factor C3 was found at the same sites as mouse IgG. In 6 out of 9 posttreatment biopsies an increase in mononuclear cells (monocytes, natural killer (NK) cells and/or T cells) was observed. Monocytes were close to the tumor cells whereas NK cells and T cells were predominantly scattered in the stroma.

Adult↗
PubMed1988

Neonatal tonsillar teratoma.

A newborn boy with a giant tonsillar teratoma or epignathus is described along with details of his management. This is a rare lesion and few survivors have been reported.

Humans↗
PubMed1986

Evaluation of C3b/C3bi opsonization and chemiluminescence with selected yeasts and bacteria using sera of different opsonic potential.

C3 fragment opsonization and chemiluminescence were assessed using two yeasts (Saccharomyces cerevisiae and Candida albicans) and two strains of bacteria (Staphylococcus aureus and Escherichia coli) following incubation with sera previously shown to be either efficient or poor in the opsonization of baker's yeast. Sera with poor function consistently fixed lower levels of C3 fragments and generated less chemiluminescence with all four organisms than sera with normal function. The differences were most marked with the two yeasts. We conclude that sera with normal complement function but manifesting a relatively common defect in the opsonization of baker's yeast have a general opsonic defect.

Adult↗
PubMed1985

Actinomadura pelletieri mycetoma from the Transvaal. A case report.

The osteophilic red grain mycetoma due to Actinomadura pelletieri is rare in southern Africa. This report describes an elderly patient with extensive bone involvement in which lymphatic spread to the inguinal lymph nodes had occurred. The diagnosis and management are discussed.

Aged↗
PubMed1985

Structures for survival.

Key assumptions underlying traditional Australian models of hospital organisations are identified and examined. Currently more appropriate assumptions are suggested for hospital modelling. Based on these some structural responses are outlined and revised models of hospital (and Area Health Board) structure are presented which differ significantly from current practice.

Australia↗