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C Granolleras

Publications and source records attributed to C Granolleras.

28 records · Page 2Linked to original sources
PubMed1987

Beta 2-microglobulin kinetics during haemodialysis and haemofiltration.

Since the identification of beta 2-microglobulin as a major component of 'dialysis amyloid', concern about its removal by different dialysis methods has been raised. Haemodialysis with regenerated cellulose membranes increases serum beta 2-microglobulin by 10-15%. Serial measurements show a very early increase during cuprophan haemodialysis, the mechanism of which is as yet unknown. After cuprophan haemodialysis, serum values return to the initial pretreatment concentrations by the time of the next haemodialysis. In contrast to regenerated cellulose, dialysis with polycarbonate lowers serum beta 2-microglobulin by 8%, and dialysis with polysulphone by 53%. As opposed to cuprophan, after polysulphone haemodialysis the serum concentrations have not returned to the initial pretreatment levels within 48 h. Comparison of beta 2-microglobulin removal using the same polysulphone membrane for haemodialysis and haemofiltration shows that beta 2-microglobulin is more effectively removed by convection than by diffusion when both treatment modes are matched for blood flow and urea clearance. Therefore, in contrast to haemodialysis with regenerated cellulose membranes, where a transient, intradialytic release of beta 2-microglobulin is induced, significant removal is observed using higher permeable membranes. These findings may have implications for the generation of 'dialysis amyloid'.

Adult↗
PubMed1984

The anatomical value of technetium-thallium subtraction scanning in detection and location of parathyroid adenomas.

99mTechnetium-201Thallium subtraction scanning was performed in 24 patients with primary (N = 5) and secondary (N = 19) hyperparathyroidism. The preoperative scintigraphy (N = 12) detected 21 of 23 enlarged glands surgically removed and was helpful for detecting abnormal location especially in the mediastinum. Postoperative scanning in patients with recurrent hyperparathyroidism confirmed the excessive growth of the remaining half parathyroid after subtotal parathyroidectomy or a missing fifth parathyroid after total parathyroidectomy and autotransplantation. False negative results were due to tumor hyperplasia. The technique is recommended prior to repeated exploration in patients presenting persistent disease to predict the location of adenomas generally unsuccessfully detected by ultrasonography and computed tomography.

Adenoma↗
PubMed1983

[Hypoxemia in hemodialysis: hemodynamic mechanism? Hemodynamic and spirometric study using acetate and bicarbonate buffers].

The background of this study is the occurrence during acetate hemodialysis (HDA) of arterial hypoxemia associated with well described vasodilatator hemodynamic changes. Our aim was to evaluate the relationship between these 2 phenomena. Eleven patients (7 males, 4 females, mean age 54 years) were compared in a protocol of HDA and bicarbonate hemodialysis (HDB) as regards their cardiac output measured by the dye dilution method, blood gases and respiratory gas measurements made at the bedside. The results show significant hypoxemia with hypocapnia as soon as the 30th minute of HDA and no significant variation of cardiac index. No significant variation of respiratory response was noted. Arterial prostaglandin levels rose significantly higher during HDA (+ 302%) than HDB (+ 163%; 2 alpha less than 0,05). The absence of a correlation between arterial hypoxemia and hemodynamic changes in HDA compared to HDB suggests that the phenomena are not interdependent. The importance of increased thromboxane activation in HDA will require further investigation.

Acetates↗
PubMedDate not supplied

Dialysis time: what you prescribe is what you get? (WYPIWYG).

The duration of a dialysis session is an essential parameter in determining dialysis efficiency and hence adequacy. The aim of this study was to measure the real dialysis time and to compare it to the prescribed time. For 12 months, 8412 dialysis treatments were allocated a number and a random sample of 100 was selected using a computer generated randomisation code. At the end of each dialysis, the time prescribed, the real time achieved, the blood volume exchanged, and any incidents occurring during the dialysis were noted. All the staff was aware of the study but nobody except the controller knew which dialysis was going to be controlled. The study population consisted of 48 patients, 25 males and 23 females. The mean duration of the prescribed dialysis time was 3.30 hours. Three patients used the same monitor per day. Results showed a loss of 10 minutes for 180 minutes dialysis prescription, 9.5 minutes for 210 minutes and 10.5 mintutes for 240-dialysis prescription. The dialyses with the greatest difference in time measured and prescribed occurred on the second (12 am to 3 am) shift (-6.23) which might be explained by the necessity for changing the bicarbonate cartridge during the shift. This loss of time represents a mean of 7 dialyses per year per patient. In conclusion, the prescribed time for a dialysis is very often not respected. A readjustment of the time during the treatment will be necessary to compensate for this loss of diffusion time and consequent efficiency.

Adult↗