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Biomedical subjects

C Graf

Publications and source records attributed to C Graf.

65 records · Page 4Linked to original sources
PubMed1982

Anterior bulbus perforation and vitrectomy in the 'minipig'.

Wound healing after experimental anterior eye perforation, including lens, ciliary, body and vitreous, was studied in 12 miniature pigs (minipigs). In half of the eyes, perforation was followed by removal of the damaged lens and suturing of the wound. In the other half, a primary subtotal vitrectomy was performed after removal of the lens. The behaviour of the connective tissue in the wound-healing process was not fundamentally changed by subtotal vitrectomy. In both groups very little fibrous ingrowth into he vitreous structure was observed, suggesting that the pig vitreous has marked antifibroplastic properties. The anatomical and technical features of vitrectomy in the minipig, and the advantages and disadvantages of this animal model are discussed. It appears that the eye of the minipig is ideal for the study of biochemical factors preventing fibrous ingrowth into the vitreous.

Animals↗
PubMed1981

[Coronary artery spasms with normal coronary arteries as the cause of recurrent ventricular fibrillations].

Coronary arterial spasms are thought to be responsible for acute myocardial infarction in some patients with normal coronary arteries. A report is presented on a patient with a history of Prinzmetal angina pectoris involving ST-segment elevations in the electrocardiogram and recurrent ventricular fibrillation. Selective coronary arteriography revealed normal coronary arteries. Administration of nifedipin and isosorbide dinitrate brought about prompt relief of pain. One year after cardiac catheterization the patient developed recurrent ventricular arrhythmias when administration of nifedipin was discontinued. It is concluded that coronary arterial spasms may occur in patients with normal coronaries and may cause transient myocardial ischemia with severe ventricular arrhythmias. A history of Prinzmetal angina pectoris is usually present and medical treatment consists in administration of nifedipin and isosorbide dinitrate.

Angina Pectoris↗
PubMed1979

The relative significance of human placental lactogen in the diagnosis of retarded fetal growth.

The purpose of this prospective study was to determine whether serial maternal venous hPL determinations could identify pregnancies resulting in growth-retarded infants from a selected population at presumed high risk for IUGR. Our results demonstrated that mean hPL levels in IUGR outcome pregnancies were significantly lower than normal after 33 weeks' gestation. Mean hPL was also lower in some pregnancies resulting in normal-weight neonates with abnormally low PI or short CHL, suggesting that these neonates, despite normal birth weight achievement, may represent previously unsuspected.

Birth Weight↗
PubMed1979

Patterns of intrauterine growth retardation.

A prospective study of 70 singleton pregnancies at high risk for intrauterine growth retardation (IUGR) was undertaken to determine 1) the differences in intrauterine growth patterns; 2) the diagnostic accuracy of obstetric techniques; and 3) the frequencies of perinatal complications. Thirty infants displayed signs of IUGR. Although only 14 infants had low birth weights, these 14, as well as the remaining 16 infants under study, displayed many other features of growth abnormalities, including a low ponderal index, short stature, and small head circumference. These data demonstrate various patterns of IUGR. Although the perinatal complications occurred primarily in the low-birth-weight group, the major growth abnormalities observed in the non-low-birth-weight group demonstrate the need for additional short- and long-term follow-up studies in both groups.

Adult↗
PubMed1977

[Determination of carcinoembryonic antigen in medical practice].

108 determinations of CEA plasma concentrations were ordered for diagnostic purposes by the medical staff of our clinic between January 1974 and April 1976. Its usefulness was retrospectively analyzed by comparing the initially suspected diagnosis serving as the rationale for CEA determination with the CEA plasma levels and the final diagnoses of the patients when leaving the hospital. Of 32 patients with proven malignancies of various types the CEA concentrations were normal in 10, slightly elevated (2.5-20.0 ng) in 15, and highly elevated in 7, all having metastatic tumors. However, in 35 of the remaining 67 tested individuals without detectable malignancies the CEA concentrations were also slightly elevated (2.5-20.0 ng); these patients either had acute infections (10 individuals), autoimmune disease disorders (1 individual), various other nonmalignant diseases (10 individuals), or were heavy smokers. In 98 of 108 patients CEA testing had been ordered either to confirm or to rule out a suspected malignancy. The results were most often of little help. Malignancies were found in 15 of 50 patients with elevated CEA, but also in 9 of 48 patients with normal values. In only 6 patients did the CEA results influence further diagnostic and/or therapeutic measures, which consequently did not always prove to be beneficial for the patient.

Carcinoembryonic Antigen↗