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Biomedical subjects

C Gnanamuthu

Publications and source records attributed to C Gnanamuthu.

24 records · Page 2Linked to original sources
PubMed1990

High incidence of subacute sclerosing panencephalitis in south India.

During 1983-7 a clinical diagnosis of subacute sclerosing panencephalitis (SSPE) was confirmed by the detection of measles virus haemagglutination inhibiting antibody in the cerebrospinal fluid (CSF) in 81 subjects resident in Tamilnadu. The antibody titre (reciprocol of the end-point dilution) in the CSF ranged from 2 to 32 and in the sera from 8 to 2048. The CSF:serum ratios of titres were 1:4-1:64 in 80 cases and 1:128 in one case. The median age at onset of SSPE was 10 years and 97% of cases were diagnosed at stage 2 and beyond. Based on the geographic distribution of 72 cases in an estimated population of 8.4 million, the annual incidence of SSPE was calculated to be 2.14 per million population, or 4.3 cases per million children below 20 years. Assuming that only 10% of all cases would have reached the level of laboratory diagnosis, the incidence may be as high as 21 cases per million population.

Adolescent↗
PubMed1990

Transient neurologic symptoms. Narrowing the vast field of causes.

Transient neurologic symptoms are common in clinical practice and can take many forms (eg, loss of consciousness, confusion, vertigo, seizures, drop attacks, behavioral abnormalities). They are often subtle and episodic and their source can be the central nervous, cardiovascular, metabolic, or endocrine system, or they can be caused by space-occupying lesions. A detailed knowledge of such symptoms and their possible causes is invaluable to confidently approach the problem in a systematic manner. Evaluation should begin with careful history taking and physical examination for intercurrent illness and a baseline set of tests. Investigation usually includes computed tomography of the brain and often magnetic resonance imaging, cerebrospinal fluid analysis, and/or electroencephalography as well. Further, specific studies are chosen on the basis of the suspected diagnosis and the information being sought.

Brain Diseases, Metabolic↗
PubMed1989

Human cerebrospinal fluid acetylcholinesterase and butyrylcholinesterase. Evidence for identity between the serum and cerebrospinal fluid butyrylcholinesterase.

Human cerebrospinal fluid contained both acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) and they were estimated in the presence of selective inhibitors. Butyrylcholinesterase of human cerebrospinal fluid was similar to human serum butyrylcholinesterase in its electrophoretic mobility, glycoprotein nature and tyramine activation of the aryl acylamidase (EC 3.5.1.13) activity exhibited by butyrylcholinesterase. Moreover antibody raised against human serum purified butyrylcholinesterase could completely immunoprecipitate butyrylcholinesterase from human cerebrospinal fluid without affecting acetylcholinesterase. It is suggested that a useful method for the precise determination of acetylcholinesterase in human cerebrospinal fluid would be removal of butyrylcholinesterase by immunoprecipitation using antibody raised against human serum butyrylcholinesterase.

Acetylcholinesterase↗
PubMed1988

Confusional states and seizures. When are they related?

Although less often due to seizures than to other conditions, confusional states may be associated with complex partial seizures in adults or absence (petit mal) seizures in younger persons and children. Absence of a metabolic disorder, intoxication, or risk factors for cerebral ischemia increases the probability that seizure caused the confusional state. A computed tomographic scan or magnetic resonance imaging of the brain is essential when the patient is acutely ill or has had several recent confusional episodes. Once a seizure disorder is diagnosed, appropriate drug therapy can be started.

Adolescent↗
PubMedDate not supplied

Resolution of cryptococcal meningitis and associated granuloma lung with antifungal therapy: report of a case.

A 49-year-old diabetic male had been unsuccessfully treated with antitubercular therapy for a granulomatous lesion of the left lung detected elsewhere nine months ago. He presented with evidence of meningitis which was found to be due to infection with Cryptococcus neoformans. Both the meningeal and lung lesions resolved after 6 weeks of combined therapy with amphotericin B and flucytosine. The report of the case along with a brief review of the relevant literature is presented.

Amphotericin B↗