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Biomedical subjects

C Giusti

Publications and source records attributed to C Giusti.

At least 91 records · Page 5Linked to original sources
PubMed1982

Vectocardiographic "bites" as possible early findings of cardiac involvement in diabetic patients without clinical evidence of heart disease.

We performed a standard vectorcardiogram (VCG) in 87 diabetics, aged 20-77 years, orally- or insulin-treated, and in 41 normal subjects. None had cardiac history or symptoms. Among diabetics, 31 had no vectocardiographic abnormalities, 23 had various VCG changes, 33 showed electrical "bites" of various length (6-22 msec) and voltage (0.05-0.3 mV). In 8 normal subjects (19.4%) we found "bites" of similar voltage and length as in diabetic patients. A significantly positive linear relation was found between "bites" length and diabetes duration, in insulin-dependent diabetics only. By step-wise regression analysis we detected, in all diabetic patients with "bites," at a fixed value of diabetes duration, a significantly negative relation between "bites" length and patients' age. Moreover, the insulin treated patients showed a metabolic regulation index significantly worse than orally-treated diabetics; also diabetes duration was significantly higher in insulin-treated subjects. If "bites" may reflect an early heart involvement in diabetes, insulin-dependent patients seem to have a more severe cardiac damage in dependence of the diabetes duration. Finally, in the younger diabetics the heart diseases seems to be earlier and more advanced.

Adult↗
PubMed1981

[Dilazep vs. nifedipine in patients with stable effort angina. A double blind randomized study (author's transl)].

In a randomized double-blind study the activity of dilazep (D) vs. nifedipine (N) was evaluated in 50 outpatients with effort angina; 26 were treated with dilazep 300 mg/die and 24 with nifedipine 30 mg/die. The observation period lasted 30 days. Before and at the end of treatment were evaluated: ECG, basal and during hyperventilation test, ergometric test, BP, HR, DP, ST depression, arrhythmias, maximum tolerated and total work done, number of anginal attacks and side effects. In 19 symptomatic subjects (D), weekly anginal crises were reduced (p less than 0.001) with normalization of 6 patients (31.6%). In group N a reduction (p less than 0.001) of anginal crises/weeks was recorded with normalization in 3 subjects out of 14 symptomatic (21.4%). In both groups ST depression was significantly (p less than 0.001) reduced. ECG during exercise normalized in 9 patients (34.6%) of D group and in 5 (20.9%) of N group. Total work performed increased after treatment in both groups. 13 patients of group D complained 19 side effects, all of short duration, whereas 54.2% (13 subjects) of group N complained 25 side effects 13 of which (52%) of short duration and 12 (48%) persistent. The results obtained pointed out a superimposable therapeutic efficacy of the two drugs, but dilazep was better tolerated.

Aged↗