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Biomedical subjects

C Giorgi

Publications and source records attributed to C Giorgi.

At least 91 records · Page 5Linked to original sources
PubMed1988

PQRST isoarea maps from patients with the Wolff-Parkinson-White syndrome: an index for global alterations of ventricular repolarization.

Isoarea maps during the PQRST sequence were computed in 22 healthy subjects and 48 patients with Wolff-Parkinson-White (WPW) syndrome. Thirty-eight patients with WPW were on no medication and 10 were treated with class I, II, or III antiarrhythmic drugs. Seventeen isoarea maps were recorded before and 17 were recorded after accessory pathway ablation. One patient had intermittent preexcitation. Body surface maps from all healthy subjects were similar, although the magnitudes of the maxima and minima showed significant variability. In all patients with WPW who were on no medication and in those on class I and II agents, PQRST maps were normal. Two patients taking amiodarone had abnormal PQRST maps, as did patients early after surgery. In the patient with intermittent preexcitation, PQRST maps were very similar during normal and preexcited beats. In conclusion, our results support the theory that the PQRST time integral reflects intrinsic recovery properties of the heart and is independent of the activation sequence.

Adult↗
PubMed1987

Computer-assisted analysis of functional anatomy of human ventrolateral thalamus.

A three-dimensional map was created by a computer-assisted analysis of functional and somatotopic organization of the target area in the human ventrolateral thalamus. Stimulation in the target area mostly elicited increased tone in skeletal muscles, with a concomitant decrease or stop of tremor. Despite averaging of all responses, no clear somatotopic organization could be demonstrated for the tonifying stimulation effects. In addition, somatosensory-evoked potentials were recorded, indicating an afferent projection to the target area.

Brain Mapping↗
PubMed1987

Stereotactic neurosurgery in the treatment of tremor.

The results of stereotactical thalamotomy in 40 adult patients suffering from tremor of different etiology are presented. A combination of lesions of VOA-VOP-ZI seems to be optimal. Early results have been excellent in 63%, good in 23%, fair in 6% and poor in 8%. Long-term follow-up showed a negative shift with 40% excellent, 6% good and 54% poor results. In Parkinson disease with predominant tremor relief of this invalidating symptom can be achieved. But L-dopa therapy must be continued and surgical treatment does not stop the general disease progression.

Adult↗
PubMed1987

Suppression of experimental allergic encephalomyelitis by retinoic acid.

Administration of retinoic acid (RA) prevented the development of experimental allergic encephalomyelitis (EAE) in Lewis rats. RA suspended in corn oil was given for 3 days before the expected onset of the disease to rats immunized with myelin and to controls. The drug suppressed the neurological symptoms as well as the perivascular infiltrates observed in vehicle-treated animals. The results indicate that under these experimental conditions, RA has immunosuppressive activity by interfering with the efferent phase of the immune response.

Animals↗
PubMed1987

[Methodology and prognostic reliability of stereotaxic biopsy in tumors of glial origin].

Between 1978 and 1984, 227 patients affected from glial tumors underwent serial stereotactic biopsy. Correct prognostic indications have been obtained in 85% of the entire series. In 10.5%, the stereotactic procedure provided only the diagnosis of the nature of the tumor, while the histological grading and prognosis remained unknown. The operative mortality was 2.6% and the permanent morbidity included 3.9% of patients who complained about worsening of the preoperative neurological conditions. The methodology of stereotactic biopsy is described in detail. The results are discussed with particular reference to the prognostic value of serial stereotactic biopsies.

Adolescent↗
PubMed1987

Three-dimensional reconstruction of neuroradiological data within a stereotactic frame of reference for surgery of visible targets.

Three-dimensional information obtained with neuroradiological exams performed under stereotactic conditions is displayed on a surgical console within the graphic reconstruction of the geometry of stereotactic frames. Planning of convenient probe trajectories can be carried out taking into account all data derived from different diagnostic techniques.

Computer Graphics↗
PubMed1987

[Teicoplanin and Gram-positive coccus infections. Results of a multicenter study on 66 cases].

Sixty-six cases of Gram positive infections were treated with teicoplanin in an open multicenter study, comprising 7 centers in Eastern France. There were 38 male patients and 28 females. Teicoplanin was given at a dose of 400 mg daily for a mean duration of 18.4 days. The most common infections were due to Staphylococcus aureus, found in 43 out of 56 documented cases. 69 (89.9%) of the 78 Gram + strains isolated had an MIC for teicoplanin of less than or equal to 2 mg/l. There were 44 serious infections (30 septicemia, 10 endocarditis, 1 joint and bone infection, 2 mediastinitis, 1 toxic shock syndrome) and 22 less serious infections (4 urinary infections, 14 skin and soft tissue infections, 3 lower respiratory infections, 1 hepatic abscess). In 42 cases concurrent medication was given: beta-lactamase in 11 cases, rifampicin in 10 cases, aminoglycosides in 22, phosphomycin in 3, pefloxacin in 5. The clinical cure and improvement rate was 90.10%. Adverse events were reported in 11 patients, and in only 3 cases was the therapy stopped. All were reversible on stopping therapy. Teicoplanin was found to be well tolerated and effective in the treatment of Gram positive infections in this study.

Adolescent↗
PubMed1987

[Treatment of septicemias and skin infections in burn patient by teicoplanin. Study of its skin diffusion].

In this study, teicoplanin was administered to burnt patients by IV and IM route in monotherapy or in association with other antibiotics. 12 cases of septicaemia and 8 severe cutaneous cocci Gram + infections were treated. Dosage varied from 5 mg/kg to 14 mg/kg. Clinical cure was observed in 89% of cases, and eradication of cocci Gram + in 83%. The MICs of Staphylococcus were between 0.25 micrograms/ml and 4 micrograms/ml, with a majority of methicillin-resistant Staphylococcus at 1. Average through serum concentrations were 7.4 micrograms/ml, and peak serum concentrations were 26 micrograms/ml (1 hour after injection). Tolerance was good in 19 of the 20 cases (95%). Skin levels of teicoplanin were found to be 1.6 times the through serum level. It was noted that in burnt patients whose UBS is superior to 100, the dose should be increased by about 50%.

Adolescent↗
PubMed1986

Wolff-Parkinson-White VCG patterns that mimic other cardiac pathologies: a correlative study with the preexcitation pathway localization.

Vectorcardiograms (VCGs) of 44 patients with a Wolff-Parkinson-White (WPW) syndrome have been analyzed with the aim to correlate the QRS loop patterns with specific preexcitation sites. The VCG QRS loops were analyzed to determine whether conduction abnormalities and myocardial infarction (MI)-like patterns observed in the WPW syndrome could be related to specific preexcitation sites identified by surgery as well as by body surface potential mapping (BSPM). Left bundle branch block pattern was observed with anteroseptal (AS) preexcitation, anterior MI pattern was seen with lateral right ventricle (LRV) preexcitation, left anterior fascicular block was observed with posterior right ventricle (PRV) preexcitation, inferoposterior and strictly posterior MI pattern was found with posteroseptal (PS) and posterior left ventricle (PLV) preexcitation, right bundle branch block was seen in lateral left ventricle (LLV) preexcitation, and right bundle branch block was observed with left posterior fascicular block in anterior left ventricle (ALV) preexcitation. These VCG criteria seem to identify accurately the preexcitation sites as observed by delta wave BSPM and at surgery investigations. Consequently, they could be useful in localizing the preexcitation site in cases of ambiguous delta vector orientation.

Adult↗
PubMed1985

Marrow transplantation for thalassaemia following busulphan and cyclophosphamide.

30 patients with homozygous beta-thalassaemia aged 6 months to 7 years received allogeneic marrow transplants following busulphan (Bu) and cyclophosphamide (Cy). Post-transplant immunosuppression was with methotrexate (MTX) or MTX and Cy. The first 6 patients received 16 mg/kg Bu and 200 mg/kg Cy. 3 died of transplant-related complications and 3 survived without thalassaemia 701-762 days after transplantation. The subsequent 24 patients received 14 mg/kg Bu and 200 mg/kg Cy. 1 died on day 28 without engraftment and 23 survived 64-624 days after transplantation. 19 of the 23 surviving patients are without thalassaemia while 4 patients with initial engraftment became thalassaemic again in 32-46 days and survived 253-624 days after transplantation. The latest death was 50 days after transplantation. The probability of developing grade 2 or greater acute graft versus host disease (GVHD) in patients with sustained engraftment was 23%. 5 patients had chronic GVHD which is still active and causing disability in 3 patients 358, 456, and 477 days after transplantation. The actuarial survival was 86% and the actuarial disease-free survival was 73%.

Actuarial Analysis↗
PubMed1985

Sequence determination of the Sendai virus HN gene and its comparison to the influenza virus glycoproteins.

The nucleotide sequence of the Sendai virus (SV) HN (hemagglutinin-neuraminidase) gene was determined. The deduced primary structure of the protein showed only one hydrophobic domain likely to represent the transmembrane region, but at its N terminus. Since the SV F protein is anchored in the membrane at its C terminus, the two SV glycoproteins are thus membrane-anchored in opposite orientations, similar to the two influenza virus (FLU) glycoproteins. Amino acid sequence comparisons of the SV HN and the FLU HA and NA proteins revealed homologies between 100 amino acids of the hemagglutinin region of the FLU HA protein and the C terminus of the SV HN, and between 200 amino acids of the neuraminidase region of the FLU NA and the central region of SV HN. Alignment of the neuraminidase, hemagglutinin, and fusion regions shared by these glycoproteins suggest the structure of a possible ancestral gene.

Amino Acid Sequence↗
PubMed1985

Sequence determination of the Sendai virus fusion protein gene.

From a genomic DNA library of Sendai virus, we have identified and sequenced clones corresponding to the F glycoprotein gene. The limits of the F gene region were defined by mapping the 5' and 3' ends of the mRNA with S1 nuclease. The Sendai virus F gene is 1821 nucleotides long. The predicted primary translation product of the single long open reading frame would code for a protein of 565 amino acids, containing a putative signal peptide, three carbohydrate addition sites, a hydrophobic region corresponding to the known cleavage/activation site of FO, and a long, very hydrophobic region near the C-terminus which probably represents the transmembrane region of the protein. The signal peptide cleavage site of the mature protein was determined by mass spectrometry. Interestingly, the amino acid sequence surrounding the cleavage/activation site of the Sendai virus F protein shows significant homology to the same region of the influenza B and C virus HA proteins, suggesting that these genes may have evolved from a common ancestor. The ability of the Sendai virus F protein to fuse membranes relative to its primary structure is discussed.

Animals↗
PubMed1985

Digital image processing to handle neuroanatomical information and neurophysiological data.

An application of computer graphics technology to functional stereotactic neurosurgery is presented. Neuroanatomical images derived from a stereotactic atlas and information retrieved from a neurophysiological data base are drawn on a graphic monitor. The pictures are oriented and scaled according to appropriate landmarks. The aim of this work is to add confidence in the surgeon's selection of the probe trajectory and to improve the knowledge of sensory and motor organization within the thalamus.

Brain↗
PubMed1984

Preparation and analysis of the nucleocapsid proteins of vesicular stomatitis virus and sendai virus, and analysis of the sendai virus leader-NP gene region.

A procedure is presented for isolating the nucleocapsid proteins, N and NP from vesicular stomatitis virus and Sendai virus respectively, in soluble form. These proteins were suitable for the determination of their blocked amino-terminal peptide sequences by gas-liquid chromatography/mass spectrometry at the low nanomole level. The N protein prepared by this procedure was previously shown to retain some of its expected biological activity. The sequence of 626 nucleotides from the 3' end of the Sendai virus genome, which includes the first one-third of the NP gene, was determined. Using this information, primer extension studies on intracellular Sendai virus mRNAs allowed the determination of the structure of the leader-NP intervening sequence and the 5' end of the NP mRNA. Comparison of the amino termini of the nucleocapsid proteins with their respective mRNA sequences revealed that these proteins are similarly processed in vivo.

Amino Acid Sequence↗