Chronic evolution of an acute epidural haematoma. A case report.
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Hematoma, Epidural, Cranial↗
Biomedical subjects
C Giordano
Publications and source records attributed to C Giordano.
[Value of indirect immunofluorescence in the diagnosis of "Trypanosoma gambiense" trypanosomiasis. 46 cases (author's translation)].
Several indirect fluorescents reactions were performed on 46 trypanosomepositive specimens which had been confirmed by parasitologic diagnosis. 38 sera analysed before the commencement of treatment were found to have a G.M.R.T. equal to I:I, 350 and the titer of antibody was, in all cases, greater than I:320. In all cases in the first phase, the titer was I:640 or higher. Four cases were followed beyond the second month and their titers decreased slowly, becoming negative in the fifth month. In 12 cases in the second phase, the cerebrospinal fluid demonstrated fluorescent antibodies although 10 cases in the first phase were negative for these antibodies. Three cerebrospinal fluid were faintly positive and these corresponded to the second phase biologically. In the treatment of individuals (using the analysis of cerebrospinal fluid for antibody) the I.F.A.T. permits the classification of the patient into one of the two phases and enables the clinician to follow the course of therapeutic effectiveness. In mass screening, apparently healthy individuals possessing a serum titer of I:640 or higher are shown to need definitive treatment for trypanosomiasis, while those with titers of I:320 are those who may either be treated with Lomidine or tested regularly for change in serum titer.
Antibodies↗
[Long-term survival following chemotherapy for recurrent head and neck cancer: patient characteristics].
Eighty-one patients with recurrent squamous cell carcinoma of the head and neck (60 patients) or undifferentiated carcinoma of the nasopharyngeal type (21 patients) were treated with cisplatin (80-100 mg/m2iv d1) and 5-fluorouracil (750-1000 mg/m2Cl d1-5). In squamous cell carcinoma patients there were 7 complete responses (11.6%), 25 partial responses (41.7%), 20 stable disease situations (33.3%) and 8 progressions (13.3%). In nasopharyngeal carcinoma patients there were 6 complete responses (28.6%), 9 partial responses (42.8%), 3 stable disease situations (14.3%) and 3 progression (14.3%). There were 5/60 patients (8.3%) with disease-free survival > 18 months in the squamous cell carcinoma group and 2/21 (9%) in the nasopharyngeal carcinoma group. All long-term survival patients had the following characteristics: good performance status (0-1 ECOG scale), disease- free interval from the first treatment > 12 months, local non-bulky relapse (rT1-2). A re-irradiation with palliative doses (20-48 Gy) was conducted in 3/7 patients. This treatment may have improved the response to drugs with regard to length and quality.
Adult↗
[Vocal function after cordectomy (traditional surgical treatment vs CO2 laser): a comparative objective-instrumental evaluation].
Concerning the wider use of the CO2 laser in the treatment of laryngeal diseases, the Authors, in a comparative study based on an objective-instrumental evaluation, evaluated residual vocal function after traditional surgical treatment (chordectomy) vs. CO2 laser treatment. Forty-one patients treated for T1a glottic carcinoma (U.I.C.C. 1987) in last 8 years were examined Vocal function following CO2 laser surgery was evaluated in 17 patients (16 males and 1 female, aged between 38 and 78, with an average age of 53) and compared to vocal function of 24 patients treated with traditional chordectomy (23 males and 1 female, aged between 51 and 73, with an average age of 58). All patients showed a minimum follow-up of 30 months and none, at the time of evaluation, had undergone phonatory re-education. Glottic functionality evaluation was performed as follows: Evaluation of anatomical and functional results by means of a rigid fiberoptic laryngoscopy and subsequent photographic documentation for successive comparative evaluation. Evaluation of residual voice quality by phoniatricians otorhinolaryngologists and the patients themselves. Recording and electroacoustic analysis of some vocal samples. Laryngeal objectivity of surgical results were constantly related to subjective and instrumental voice evaluation. Phonatory results in patients treated with CO2 laser were better than those found in patients treated with traditional chordectomy.
Adult↗
[A cancer marker study in patients with neoplastic pathology of the neck and head area].
Specific markers able to detect either the presence of tumours or to identify the histological type of tumour are not currently available. Previous work yields an inconsistent picture of actual effectiveness of oncological markers, we therefore carried out a study on the cancer patients in our clinic. The present paper considered five markers (CEA, SCC, ca 19-9, TPA and Ferritin) and tested their effectiveness in diagnosing and following patients with head and neck neoplasias. The study was carried out on 102 patients, divided into three groups: 59 had been histologically diagnosed cancer but had not received any treatment (first group), the remaining 43 who had been treated (second group). We have also monitored the first group of no treated patients six months after therapy (third group). Our results suggest that while no significant conclusions may be drawn from SCC and CA 19-9, we found interesting results concerning Ferritin. Indeed Ferritin values increased by 22% in the first group, by 26% in the second one and by 19% in the third one. CEA and TPA values increased in non treated patients only by 22% and 12% respectively while they did not alter in the treated ones and they altered by 10.5% and by 10% respectively six months after therapy. Although our data are still preliminary and speculative and further evidence is needed, we can infer that the stage of the cancer and the positive markers appear to be concluded. The correlation is even stronger when all the cases are considered, without introducing the statistical and epidemiological variables.
Adult↗
Angiogenesis: prognostic significance in laryngeal cancer.
The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or without radiotherapy. The results obtained indicate that: a) MC higher than 130 microvessels/mm2 is a cut-off value that distinguished patients who relapsed during the follow up period; b) multivariated analysis indicates that MC (p < 0.00001) is an independent predictor of disease free-survival; c) multivariated analysis selectively done on cases with relapse demonstrates that MC correlates with the presence of metastasis (or/and M) with local relapse (T). We suggest that MC is useful in the assessment of prognosis in LSCC and probably will permit selection of patients that could benefit from anti-angiogenic therapy associated with chemotherapy and/or radiotherapy.
Adult↗