Search PubMed⌕ Search

Biomedical subjects

C Gillberg

Publications and source records attributed to C Gillberg.

At least 163 records · Page 9Linked to original sources

Psychosocial effects on siblings of children with autism and mental retardation: a population-based study.

The probands of this study were 60 children and young adults between 5 and 20 years of age, 20 of whom had siblings with autism, 20 of whom had siblings with mental retardation, and 20 of whom had siblings who were free of handicap. The three proband groups were matched for gender, birth order and socioeconomic status. The children were questioned about their sibling relationships and about particular problems they faced concerning their handicapped brothers or sisters and about problems concerning themselves. Parents were interviewed about the healthy child's behaviour and social adjustment. Mothers completed the Eysenck Personality Inventory concerning themselves. Siblings of handicapped children and especially siblings of children with autism were more concerned about the future. They also felt lonely more often and many of them had peer problems. They often regarded their handicapped siblings as a burden. They tended to have only one sibling. Siblings often did not know why their handicapped brother or sister was different from other children. There were more behaviour disturbances in the siblings of handicapped children and mothers with a child with autism reported more 'stressful events'. There were no differences as regards the personality of the mothers and the self-concept of the children between the three groups.

Adaptation, Psychological↗

Chromosomes in anorexia nervosa. A study of 47 cases including a population-based group: a research note.

Forty-seven cases with anorexia nervosa (including a total population group) and 47 sex-, age-, and school-matched comparison cases were subjected to chromosome analyses in a blind fashion. No major abnormalities were found in any of the cases. Sex chromatin was analysed in buccal smears from the girls. No differences between the anorexia nervosa and the comparison cases were found. It seems that chromosomal/sex chromatin analyses in anorexia nervosa are not warranted.

Adolescent↗

Behavioural problems in children with infantile hydrocephalus.

The occurrence of behavioural problems in a population-based series of children with infantile hydrocephalus (non-spina bifida) was analysed, using parent questionnaires. Children with both infantile hydrocephalus and mental retardation had significantly more behavioural problems compared with those with no mental retardation and controls. Inattentiveness and hyperactivity were particularly typical. No differences were found between children with infantile hydrocephalus and no mental retardation and the control group.

Adolescent↗

Prader-Willi syndrome in a Swedish rural county: epidemiological aspects.

The total population under 25 years of age in one rural county in Sweden was screened in an attempt to find all cases of Prader-Willi syndrome and to establish prevalence rates for the disorder. 11 clear and five suspect cases were found. For the seven- to 25-year-old age-group the prevalence was 13 per 100,000 for clear cases only, but 20 per 100,000 if borderline cases were included. There was a slight over-representation of males, but it was possible that this was a result of under-representation of females in the very young age-groups, in whom hypogonadism may be difficult to diagnose.

Adolescent↗

Hypomelanosis of Ito in three cases with autism and autistic-like conditions.

Two girls and a boy showing autistic behaviour and fulfilling the criteria for autistic disorder, Asperger syndrome or atypical autism were diagnosed as having hypomelanosis of Ito syndrome. It is suggested that skin changes indicating underlying neurocutaneous disorders be meticulously looked for in all cases with autism and autistic-like conditions.

Adolescent↗

Autistic symptoms in children with infantile hydrocephalus.

From a population-based series of children with Infantile Hydrocephalus (IH) 69 patients (mean age 11.7 years) were examined with respect to the occurrence of autistic symptoms. Autistic symptomatology was evaluated according to a modified short Swedish version of the so-called Autism Behavior Checklist. Sixteen of the 69 IH children (23%) reached a score which was considered indicative of autistic symptoms (AS) in the child. This group was compared with the remaining 53 IH children without autistic symptoms (non AS). Significant differences were found between these two groups with respect to aetiological and clinical data. In the AS group 44% were born preterm as compared to 9% in the non AS group. CT scan showed major abnormalities in 64% of the AS children while this was present in 28% in the non AS group. The occurrence of major neuroimpairments--epilepsy, mental retardation and cerebral palsy--was 50%, 88% and 50% in the AS group as compared to 9%, 23% and 19% respectively in the non AS group. It was concluded that the more severe the brain damage in children with IH the more likely that autistic symptomatology would ensue. This implies that specific neuropsychiatric services to these families are required.

Autistic Disorder↗

Is autism more common now than ten years ago?

A total population study of children, aged 13 years and under, suggested that there has been an apparent rise in the frequency of autistic disorder and autistic-like conditions (excluding Asperger's syndrome) in one area of western Sweden over the last ten years. The frequency was 4.0/100,000 in 1980, 7.5/10,000 in 1984 and 11.6/10,000 in 1988 in the city of Göteborg. Even though the prevalence rates refer to slightly different age cohorts, it was concluded that the apparent increase is in part due to better detection, but also to new cases born to immigrant parents. Typical cases of autistic disorder accounted for 75% of cases, and 20% had normal or near-normal IQs.

Autistic Disorder↗

CSF beta-endorphins in childhood neuropsychiatric disorders.

Thirty-one children with autistic disorder, 8 with the Rett syndrome (RS), 2 with childhood disintegrative disorder and 5 with infantile spasms were compared with healthy adult controls with respect to cerebrospinal fluid (CSF) beta-endorphin levels. The autistic disorder and RS groups showed significantly lower values than the other groups. There were no age trends within the various groups. Further study of CSF beta-endorphins in these disorders and blindly examined age matched controls is warranted.

Adolescent↗

Autism under age 3 years: a clinical study of 28 cases referred for autistic symptoms in infancy.

Twenty-eight children referred with a preliminary diagnosis of autistic disorder under age 3 yrs were extensively examined from the neuropsychiatric point of view and followed up for several months to several years. A diagnosis of autistic disorder was confirmed in 75% of the cases. A variety of associated medical conditions was identified. It was concluded that autism can be diagnosed in a substantial proportion of cases before age 3 yrs and that the neurobiological background is similar to that seen in older autistic children.

Autistic Disorder↗

Mental retardation in urban children: a population study of reduced optimality in the pre-, peri- and neonatal periods.

One hundred and thirty representative cases of mentally retarded children in Sweden were surveyed in order to detect reductions in optimality in the prenatal, perinatal and postnatal periods. There was a small but statistically significant reduction in optimality, particularly pertaining to the prenatal and neonatal periods. It is of interest, however, that these mentally retarded children had smaller reductions of optimality than did children with cerebral palsy or infantile autism.

Adolescent↗

The syndromes described by Kanner and Rett-Hagberg: overlap in an extended family.

An extended family is reported in which Rett-Hagberg syndrome, autism with mild ataxia and autism with profound mental retardation occurred separately in three female second-cousins. The authors suggest alternative explanations for the possible association between autism and Rett-Hagberg syndrome: that they may be closely related genetic disorders, or that they may constitute relatively homogeneous phenotypes with several possible aetiologies.

Adolescent↗

Do children with autism have March birthdays?

One hundred people with autistic disorder (DSM-III-R) without a known cause who comprised a total population of children with autism were compared with "autistic-like" children, Asperger syndrome and age-matched comparison children from the general population and were examined with regard to month of birth. There was an excess of March birth in the group of children with autism. The possible reasons for this finding are discussed.

Adolescent↗