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Biomedical subjects

C Gibert

Publications and source records attributed to C Gibert.

At least 91 records · Page 5Linked to original sources
PubMed1982

Serum levels of antibody to toxoid during tetanus and after specific immunization of patients with tetanus.

Levels of serum antibody to toxoid in patients with tetanus who were immunized with toxoid differed from those in immunized healthy persons in two respects. (1) Base-line levels preceding immunization were higher among patients with tetanus than among young or elderly healthy person, even though the patients with tetanus were evaluated before specific serotherapy. This observation suggests the occurrence of immunostimulation, whether specific or not, by disease during the incubation period. (2) No significant increase in levels of antibody to toxoid was detected among patients with tetanus from the first to the last evaluable serum sample, whereas a significant increase was observed among healthy persons. Specific immunosuppression induced by tetanus toxoid or serotherapy could account for this ineffectiveness of immunization among patients with tetanus, although nonspecific immunosuppression induced by prolonged and severe illness cannot be excluded. Among healthy persons, active immunization is less effective in elderly persons than in young persons [2]. However, age cannot, by itself, account for the type of antibody production observed in patients with tetanus.

Adult↗
PubMed1982

Severe meningitis due to Listeria monocytogenes. A review of 40 cases in adults.

During a 10-yr period, 40 cases of severe Listeria monocytogenes meningitis were observed. All patients showed consciousness disturbances and 27 of them (68%) focal neurologic signs. Cranial nerve palsies were common (57%). Early general seizures (13 patients) and presence of underlying disease (12 patients) were associated with a high mortality rate. Although the management of antibiotic therapy is open for discussion, chloramphenicol (used in 7 patients) seems to be more effective than other drugs.

Adult↗
PubMed1982

Circulating immune complexes and severe sepsis: duration of infection as the main determinant.

The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied over a period of 2 years. CIC were detected in 42% of patients studied. Interindividual variations were observed but it was found that the level of CIC increased statistically with time (P less than 0.001). CIC were statistically linked with cryoglobulinemia (P less than 0.001), rheumatoid factor (P less than 0.001) and a decreased CH50 (P less than 0.05). CIC were more frequent in patients with endocarditis (53%) than in patients with mediastinitis (24%). However, when the duration of the infection was taken into account the difference was no longer significant. No relation could be evidenced between the incidence of CIC and clinical symptoms including prognosis and renal signs. In our experience, determination of CIC does not have a critical clinical value.

Adult↗
PubMed1981

[Herpes encephalitis in adults and interferon (author's transl)].

In 10 adult patients with herpes encephalitis type I interferon synthesis was detected in the cerebrospinal fluid at the onset of the disease, but not in serum collected the same day as the CSF. In 20 controls with various non-herpetic infections associated with neurological disorders, type I interferon was found neither in CSF samples nor in sera. The early intrathecal synthesis of type I interferon during adult encephalitis therefore strongly support the assumption of a herpetic origin. The role of CSF interferon in the pathogenesis of the disease and the absence, or presence in small amounts, of serum interferon are discussed. These findings raise queries about the treatment of herpes encephalitis with parenteral interferon combined with nucleoside analogues.

Adult↗
PubMed1981

Cryoglobulins, circulating immune complexes, and complement activation in cerebral malaria.

A total of 32 patients with Plasmodium falciparum malaria were studied. Of these, 23 had benign infections, and 9 had typical cerebral malaria. Cryoglobulins, circulating immune complexes detected by a C1q-binding assay, and hypocomplementemia were found in eight of nine patients with cerebral malaria. Raised levels of complement component 3 breakdown products (C3d) were found in the seven patients tested. Peak levels of circulating immune complexes and C3d were associated with thrombocytopenia. In contrast, in patients with benign Plasmodium falciparum malaria, cryoglobulins and circulating immune complexes were found only in 3 of 23 patients. Similarly, hypocomplementemia was detected only in 5 of 23 patients. These observations suggest that the intensity of the immune response and of the associated complement activation may be important factors in the pathogenesis of cerebral malaria.

Adult↗
PubMed1981

[Diabetic retinopathy : results of retinal photocoagulation (a five-year follow-up) (author's transl)].

Case-reports on 187 (321 treated eyes) were analyzed in order to assess the benefits of argon laser photocoagulation in diabetic retinopathy. Results are presented according to the clinical type and as a function of the histological type of the lesions. The authors propose a protocoagulation approach which prevents the appearance of new vessels by destroying the vasoformative hypoxic retinal areas and to treat the existing new vessels and the macular edema. The indications and the approach depend mainly careful angiographic assembling and from the results of examination of the macular region.

Adult↗