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Biomedical subjects

C Georgescu

Publications and source records attributed to C Georgescu.

At least 19 recordsLinked to original sources
PubMed2005

Acute esophageal necrosis associated with alcoholic hepatitis: is it black or is it white?

Acute esophageal necrosis is an uncommon condition diagnosed during endoscopy from the black appearance of the esophagus. We report three cases of acute esophageal necrosis, associated with severe alcoholic hepatitis. The pathogenesis was multifactorial in our patients, with gastroesophageal reflux combined with hypoperfusion probably being the key factor for the esophageal lesions. The patients presented a continuum of endoscopic appearances, ranging from the characteristic black esophageal mucosa with ulcerations to a thick white exudate that peeled away (pseudomembranes). However, esophageal biopsy specimens from all three patients had the same histological pattern of severe inflammation and necrosis. Thus, the possibility of acute esophageal necrosis should also be considered in patients with extensive necrosis covered by a white exudate, but without the characteristic pattern of a "black esophagus"; and the diagnosis should subsequently be confirmed by mucosal biopsies. Our report showed that ethanol-induced acute esophageal necrosis can appear in patients with a high alcohol intake, especially in immunosupressed patients with alcoholic hepatitis.

Adult↗
PubMed1998

Long-term prognosis of surgically-treated aortic aneurysms and dissections in patients with and without Marfan syndrome.

OBJECTIVE: Aortic aneurysms and dissections are the leading causes of premature death in Marfan syndrome (MfS). This study aims to compare long-term results of surgically treated aortic aneurysms and dissections in patients with and without MfS in respect to early and late prognosis. METHODS: From March 1975 to August 1994, 33 patients with classic MfS (group A, age 34.2 +/- 9 years) and 298 patients with non-fibrillinopathic aortic disease (group B, age 54 +/- 13 years) underwent aortic surgery. Acute dissections occurred in 57.6 (A) versus 37.9% (B). A total of 54.6% of patients in group A were treated with a composite graft versus 16.4% in B. The aortic arch and the descending aorta was replaced in 30.4% of MfS patients and 24.9% of patients without MfS. RESULTS: We observed 7 (25.0%, A) versus 35 (14.2%, B) late deaths among the 28 (A) versus 247 (B) early survivors. In 5 patients (17.9%) of A and 8 patients (3.2%) of B, late death was caused by redissection or recurrent aneurysm (P < 0.001). Long-term survival after 5, 10 and 15 years in group A was 82 +/- 7, 60 +/- 11 and 30 +/- 22%, and 75 +/- 3, 69 +/- 3 and 64 +/- 4% in group B. A total of 22 reoperations were performed in 11 MfS patients, 17 reoperations were due to recurrent aortic diseases. Three of the 8 patients underwent reoperation after Wheat procedure because of sinus valsalva aneurysm. None of the patients with composite graft replacement needed reoperation in this segment, but 3 patients suffered from redissection at the proximal aortic arch. In group B, reoperations were significantly less frequent (10.7%) compared to MfS patients (66.7%; P < 0.001). CONCLUSIONS: Surgical treatment of aortic disease in MfS patients is associated with a high risk of redissection and recurrent aneurysm. If the ascending aorta needs to be replaced, we recommend the composite graft technique and a more aggressive approach to reduce the frequency of distal reoperations. In order to reduce the high reoperation rate in MfS patients, frequent clinical follow-up may contribute to improve life expectancy in MfS patients.

Adult↗
PubMed1985

An appraisal of a cell culture test for revealing the presence of E. coli thermolabile enterotoxin (L.T.).

Three methods were comparatively used for revealing the presence of thermolabile enterotoxin (L.T.) of E. coli strains causing diarrheal illness of children. From 228 patients 52 L.T.+ strains (22.8%) were identified with the classic rabbit skin test out of which 50 L.T.+ strains (21.9%) also reacted positively in a cell culture test using CHO-KI cells and only 33 L.T.+ strains (14.4%) in the rabbit intestinal loop test. The cell culture test appears to have a constant sensitivity, it is inexpensive, easy to perform and therefore adequate to be carried out in experienced field laboratories.

Adolescent↗
PubMed1981

Sinoatrial node electrical activity recording through intracavitary leads.

Electrical activity of the sinoatrial node was recorded on bipolar intracavitary leads at superior vena caval-right atrial junction in ten patients. These recordings may be important for practical purposes, but they still have many limitations concerning the amount of the atrial potentials which can be recorded together with sinoatrial potential.

Electrocardiography↗
PubMed1979

Analysis of human atrial fibrillatory waves using monophasic action potential technique.

In 29 patients with atrial fibrillation, using the monophasic action potential technique, the fibrillatory waves were recorded and analyzed by statistical methods. Concerning the characteristics of the fibrillatory waves there are no differences between patients with rheumatic heart disease and with coronary heart disease. The patients with paroxysmal forms and those without heart failure and with normal heart size, have similar statistical data with regard to their fibrillatory waves. From the data presented, it could be possible to predict the efficacy of conversion to sinus rhythm and also the sinus rhythm stability after conversion.

Action Potentials↗
PubMed1978

Two varieties of the onset of atrial fibrillation studied by monophasic action potential recording.

Two types of the initiation of atrial fibrillation are demonstrated in the continuous recordings of right atrial monophasic action potentials. In the first way, more common, atrial fibrillation takes place suddenly after an an extrasystolic atrial beat, in the second one it develops gradually after atrial tachycardia. In the first type the micro reentry starts from the beginning, in the second type only after sustained focal atrial tachycardia.

Action Potentials↗
PubMed1977

[Increased atrial refractoriness: an explanation for the rarity of atrial arrhythmias in chronic cor pulmonale (author's transl)].

Right atrial monophasic action potential was recorded using a suction electrode catheter in 20 patients with chronic cor pulmonale. The duration of right atrial monophasic action potential was recorded using suction electrode catheter in 20 patients with chronic corpulmonale. The duration of right atrial monophasic action potential was 397 +/- 17 msec, longer than the normal value of 325 +/- 37 msec found in 30 normal subjects. The conclusion of our work is that the long right atrial monophasic action potential duration may explain the sinus rhythm stability and the rarity of atrial arrhythmias in chronic cor pulmonale.

Action Potentials↗
PubMed1976

Long-term controlled clinical trial of a new anti-inflammatory drug, diftalone, in rheumatoid arthritis.

A long-term (two years) double-blind, comparative trial of diftalone (Aladione) 500 mg versus indomethacin 75 mg per day, in rheumatoid arthritis (thirty-two patients), has shown a similar effectiveness for both anti-inflammatory agents on various clinical parameters of disease activity, some better results being obtained for diftalone as regards the capacity of reducing erythrocyte sedimentation rate. The tolerability of diftalone proved to be somewhat superior, as is shown by the lower number of patients complaining of side-effects or being dropped out for intolerance, and by the lower frequency of central nervous system disturbances.

Arthritis, Rheumatoid↗