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Biomedical subjects

C Gentsch

Publications and source records attributed to C Gentsch.

47 records · Page 3Linked to original sources
PubMed1983

Regional distribution of [3H]imipramine binding sites in the CNS of Roman high and low avoidance rats.

The high affinity binding of [3H]imipramine to membranes was compared in 7 brain regions from two psychogenetically selected rat lines (RHA/Verh, RLA/Verh). A significantly higher binding in RHA/Verh rats, as compared to RLA/Verh rats, was found in cortex and striatum. All other regions, except hypothalamus, showed a trend in the same direction (RHA/Verh greater than RLA/Verh). In the hypothalamus, however, [3H]imipramine binding for RLA/Verh rats significantly exceeded that found in RHA/Verh animals.

Animals↗
PubMed1982

Behavioural comparisons between individually- and group-housed male rats: effects of novel environments and diurnal rhythm.

Individually-housed rats, when compared with group-housed controls, have been previously shown to be hyper-reactive when exposed to an openfield at the beginning of the dark-phase; this was not due to elevated spontaneous activity. In the present experiments locomotor and rearing activities were determined immediately after exposing animals to a novel environment, and after 6 and 24 h of habituation to the test-environment. Additionally, after 24 h of adaptation, animals' responses towards a modification of the test-environment were examined. Four parallel experiments were carried out, each starting at a different time in the light/dark cycle. Individually-housed rats were hyper-reactive in novel environments and showed a slower habituation at all time points tested. Part of behavioural parameters show clearcut day/night variations, but differences between individually- and group-housed rats do not seem to be influenced by the time of day.

Animals↗
PubMed1982

Different reaction patterns in individually and socially reared rats during exposures to novel environments.

Individually and group-reared male rats were behaviourally compared after various periods of different housing, (i) during a first exposure to the new environment, and (ii) after habituation (two repetition trials) to the situation, during a fourth exposure in a slightly modified test-box. Compared to group-housed controls an elevated locomotor activity upon the first exposure and a reduced reaction in response to the slight modifications were found in individually housed rats.

Aging↗
PubMed1981

3H-Diazepam binding sites in Roman high- and low-avoidance rats.

The binding of 3H-diazepam to membrane benzodiazepine receptors was examined in 2 psychogenetically selected lines of rats, which differ according to the selection criterion in avoidance behaviour (RHA/Verh greater than RLA/Verh) and, in addition, in emotionality (RHA/Verh less than RLA/Verh). RHA/Verh rats tended to show higher specific diazepam binding in all CNS-subregions when compared with RLA/Verh animals. Significant differences were found in the cortex, striatum, hippocampus, thalamic region and pons-medulla. These results reinforce the contention that a system involving benzodiazepine receptors may play a role in emotional behaviour.

Animals↗
PubMed1981

Individually reared rats: alteration in noradrenergic brain functions.

The influence of social isolation in rats on postsynaptic alpha 1- and beta-adrenergic receptors, on the cAMP generating system and on the presynaptic uptake mechanism in the central noradrenergic system was examined in different brain regions. Rearing rats in isolation from the 19th day of life for 12 weeks leads in all regions to a general tendency for a reduction in 3H-DHA binding, to an enhanced 3H-WB4101 binding and to a decreased responsiveness of the noradrenaline sensitive cAMP generating system. These changes reach significant only in the pons-medulla-thalamus region. Isolated rats showed an increased synaptosomal uptake of noradrenaline, most pronounced and significant in the hypothalamus. Our data provide further support for a disturbance in central noradrenergic function in isolated rats.

Adenylyl Cyclases↗
PubMed1979

[Physical and static-motor development of patients with clefts at ages from 0 to 10 years].

In the framework of a cross-sectional and longitudinal study, 703 anthropometric determinations were performed in 581 cleft patients aged from 0 to 10 years. The values obtained for body length, body weight and body weight and chest expansion were compared with the standard values established by Marcusson and Sälzler. The values for the circumference of the head were compared with the standard values of Nellhaus. The results show that from 87.4 to 97.2% of all these measurements of the body lie within the interval of x +/- 2 s. The growth in length is but slightly affected by the cleft. The values for body weight and chest expansion range with the lower standard values, especially in females and in patients with bilateral cheilognathopalatoschisis. There is a general trend towards circumferences of the head that are greater than the mean standard value. Developmental retardation is more often seen in females, but it is of shorter duration than in male cleft patients. Cleft patients who did not make up for retardation were afflicted with additional deformities or malformations or with mental defects.

Anthropometry↗
PubMedDate not supplied

Platelet 3H-imipramine binding sites in depressed patients and healthy controls: a comparison between morning and afternoon samples.

Platelet 3H-imipramine binding was compared between 19 hospitalized, depressed patients and age-matched controls (n = 11). For each individual person blood samples were withdrawn at 8 a.m. and 3 p.m. on two separate occasions (day 0 and day 28). Mean Bmax and Kd values did not differ between depressed patients and healthy controls at any of the four time-points tested, and no significant differences could be established between the different time-points, though there were irregular intraindividual variations.

Adult↗