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C Garbarsch

Publications and source records attributed to C Garbarsch.

60 records · Page 4Linked to original sources
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Effects of intermittent and continuous hypoxia on the aortic wall in rabbits.

Male albino rabbits were exposed to intermittent nitrogen breathing every 30 sec for 5 sec, 15 min daily over a period of 3 weeks, and every 30 sec for 5 sec over a period of 10 hr. A third group of animals was exposed continuously to 8% oxygen breathing for 2 weeks. Neither intermittent not continuous hypoxia induced gross or microscopic alteration in the aorta. The effects of hypoxia upg which hypoxia was distributed than upon the total period or the degree of hypoxia. Exposure to hypoxia over a short period stimulated the synthesis of glycosaminoglycans, whereas distribution of the hypoxia over a longer period resulted in a reduction in the amount of glycosaminoglycans, probably secondary to an inhibition of the synthesis. Similarly, continuous exposure to 8% oxygen for a longer period decreased the aortic content of collagen. The alterations in the glycosaminoglycans and collagen induced by hypoxia may cause changes in the passage of macromolecules through the aortic wall. The changes may also influence the mechanical properties of the aorta and lead to impaired healing of vascular injury.

Animals↗
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High serum levels of YKL-40 in patients with systemic sclerosis are associated with pulmonary involvement.

OBJECTIVES: YKL-40, a growth factor of connective tissue cells, is elevated in sera from patients with diseases characterized by inflammation, tissue remodelling, or fibrosis. The aim of the study was to determine serum YKL-40 levels in patients with systemic sclerosis (SSc) and to explore any possible clinical and prognostic associations. METHODS: YKL-40 was measured in sera from 88 patients with SSc (26 with diffuse and 62 with limited skin involvement) and in sera from 88 matched healthy controls. Immunohistochemical staining for YKL-40 antigen was performed in a biopsy from a patient with pulmonary SSc. RESULTS: Serum YKL-40 levels of the SSc patients were significantly higher than those of the controls (p<0.00001). Patients with pulmonary fibrosis by chest X-ray, obstructive ventilatory pattern, reduced diffusing capacity (DLco), and digital joint deformity due to skin retraction had significantly higher serum YKL-40 compared with patients without these findings. Patients with elevated serum YKL-40 had shorter survival times than patients with normal serum YKL-40 (p = 0.0005), although this was not independent of age and pulmonary function. YKL-40 protein expression was found in inflammatory cells in fibrosing pulmonary tissue from a patient with SSc. CONCLUSIONS: Serum YKL-40 is elevated in patients with SSc with pulmonary involvement.

Adipokines↗