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Biomedical subjects

C Galli

Publications and source records attributed to C Galli.

At least 325 records · Page 18Linked to original sources
PubMed1976

Effects of rapeseed oil on fatty acid oxidation and lipid levels in rat heart and liver.

The comparative rates of oxidation of erucic and oleic acids and of their CoA esters were studied in heart and liver mitochondria of rats fed a standard diet or semisynthetic diets containing 25% of the calories as either rapeseed oil (46.6% erucic and 10.4% eicosenoic acid) or olive oil, for a period of 5 months. The long exposure to the diet containing 25% rapeseed oil did not alter the oxidative activity of mitochondria and did not induce morphological changes in the heart. It is confirmed that erucic acid is oxidized in mitochondria at lower rates than other long chain fatty acids and that its activation as CoA derivative may be one of the rate limiting steps of the overall oxidationprocess. Total lipids and triglycerides do not significantly change in the heart whereas they increase in the liver of rats fed the diet containing rapeseed oil.

Animals↗
PubMed1976

Correlation between release of free arachidonic acid and prostaglandin formation in brain cortex and cerebellum.

Levels of free arachidonic acid and of prostaglandin F2alpha and E2 have been measured in both brain cortex and cerebellum of rats killed by focussed microwave irradiation, and after decapitation followed by ischemia. The same parameters were studied during incubation assays. It was found that: a) after ischemia levels of both free arachidonic acid and of prostaglandins in cerebellum are lower than in brain cortex, b) formation of prostaglandins from endogenous precursor in incubated cortex is higher than in cerebellum, c) release of free arachidonic acid occurs mainly during the time interval between the sacrifice of the animals and the beginning of the incubation, whereas prostaglandins are formed mainly during the incubation assay. The correlation between release of free arachidonic acid and prostaglandin formation is discussed.

Animals↗
PubMed1975

Brain free fatty levels in rats sacrificed by decapitation versus focused microwave irradiation.

Values are presented for whole brain free fatty acid levels of rats sacrificed by decapitation vs focused microwave irradiation. Free fatty acids were quantitated by specific colorimetric analysis. Within ca. 1 min of sacrifice by either decapitation or microwave, rat whole brain free fatty acid concentrations ranged from ca. 80-100 mug/g fresh tissue. If the brain remained in the head for a total of 5 min after decapitation, free fatty acid levels increased by over 100%. The free fatty acids at this time were enriched with arachidonic acid. The increase in free fatty acid levels following decapitation was completely absent in rats sacrificed by the microwave irradiation. This microwave technique could be a valuable tool in determining free fatty acid and other heat stable compounds in brain tissue.

Animals↗
PubMed1973

High dose frusemide in established acute renal failure.

The results of treatment with frusemide in 105 patients with established acute renal failure admitted during the past six years were reviewed and compared with control groups. Daily doses of 2,000 mg of frusemide administered from the day of admission onwards produced a significant increase in the number of patients who attained a diuresis and decreased the duration of oliguria.The reduction in the time spent in hospital and in the number of dialyses required suggests that the use of frusemide in these large doses is indicated in patients with severe established acute renal failure.

Acute Kidney Injury↗