Search PubMed⌕ Search

Biomedical subjects

C Gailloud

Publications and source records attributed to C Gailloud.

At least 37 records · Page 2Linked to original sources
PubMed1990

[Treatment of retinoblastoma and results. Lausanne 1963-1989].

97 cases of retinoblastoma were studied with particular attention to methods of treatment and results. The series includes 41 unilateral cases (42%) and 56 bilateral cases (58%), giving a total of 153 eyes. Of these, 19 (20%) were familial cases. Immediate enucleation was necessary in 88 of the 153 eyes; 61 eyes received conservative treatment; 4 eyes, including one bilateral case, showed spontaneous recovery (retinomas). Conservative treatment consisted of high-voltage external beam irradiation in 43 cases, cryo or photocoagulation in 12 cases, and radioactive applicators in 6 cases. The mortality-rate in cases with over 2-years follow up is of 11%. In 65% of treated cases the eye was saved, with 87% of these retaining useful or central vision. The most serious complications are radiation retinopathy (19%), cataract (16%) and exsudative retinal detachment (9%).

Brachytherapy↗
PubMed1989

Constitutional karyotype in retinoblastoma. Case report and review of literature.

High resolution karyotype was performed in 13 retinoblastoma patients. A mosaic pattern for del(13)(q14.1;q14.3) was found in a girl with sporadic bilateral retinoblastoma and midface dysmorphism. In addition, 162 cases of 13q aberrations were reviewed, including 140 retinoblastoma patients and 22 non-penetrance 13q14 deletions. Some epidemiological and genetic involvements are discussed.

Carboxylesterase↗
PubMed1989

[Irradiation treatment of choroidal hemangiomas].

Therapeutic results obtained following the treatment of 24 cases of choroidal hemangiomas (21 solitary and 3 in a Sturge-Weber syndrome) treated with 60Co applicators or an accelerated proton beam were analyzed. The observation period was less than 2 years for 4 cases, 2 to 5 years for 10 cases, 5 to 10 years for 7 cases and more than 10 years for 3 cases. Reabsorption of retinal detachment without any recurrency was obtained for all the cases. The V.A. was increased in 16 cases, did not change in 4 cases and decreased in 4 other cases. Final V.A. was 6/7.5 or more in 9 cases (37.5%), 6/60 à 6/7.5 in 6 cases (25%), and 6/60 or less in 9 cases (37.5%). None of the cases we treated presented complications induced by radiotherapy (actinic papillitis, circulatory disturbances in the macular area, or neovascular glaucoma). The comparison of the results we obtained with cases treated by photocoagulation or external radiotherapy demonstrated a slight advantage in favour of the focalized radiotherapy, which is not statistically significant because of the small number of cases included in the studies. Meanwhile, contact radiotherapy and irradiation with an accelerated proton beam seems to be a substantial alternative for the treatment of large hemangiomas and tumors invading the macula.

Adult↗
PubMed1988

[Report on the conservative treatment of melanoma of the uvea at the Lausanne University Ophthalmologic Clinic].

A great number of techniques are currently available for the conservative treatment of uveal melanomas: ocular applicators emitting gamma rays 60Co, 125I) or high-energy beta rays (106Ru/106Rh), light photocoagulation, surgical excision, and accelerated proton beam irradiation. Life expectancy following conservative treatment is equal to or better than that following enucleation. This is demonstrated by nonrandomized comparative studies, and by the authors' own long-term results following the conservative treatment of melanomas by 60Co applicators: mortality due to metastases of small melanomas was 3% (V = smaller than 10 x 10 x 3 mm), with medium-size melanomas it was 12% (V = 10 x 10 x 3-15 x 15 x 5 mm), and with large melanomas 21% (V = larger than 15 x 15 x 5 mm). Accelerated proton beam irradiation of uveal melanomas is currently the method of choice for the conservative treatment of uveal melanomas. The sharp boundaries of the irradiated zone, the uniformly distributed irradiation dose, and beam-splitting are the main advantages of this technique. During the last three years, 310 cases of uveal melanoma have been treated in Switzerland with an accelerated proton beam. Of these, 214 were followed up for more than one year. Eight patients (3.9%) died of metastases. Visual acuity was identical or superior to initial visual acuity in 60.3% of the cases, while 39.6% exhibited a deterioration of vision or a functional loss. Favorable results achieved by conservative treatment of uveal melanomas considerably limited the indications for enucleation, which is now only performed in exceptional situations.

Brachytherapy↗
PubMed1988

[Retinoblastoma and pseudoretinoblastoma: diagnostic study].

Between 1963 and 1987 admitted Lausanne University Eye Hospital 140 infants with suspected retinoblastoma. Of these, 98 (70%) were subsequently confirmed cases, while 42 (30%) were found to be suffering from a benign disorder. Among these pseudoretinoblastomas, Coats' disease was found to be the most prevalent (21%) in this study. The examination procedure is discussed and the importance of genetic research is emphasized.

Child↗
PubMed1986

Ophthalmia nodosa and the oculoglandular syndrome of Parinaud.

We present a case of ophthalmia nodosa and Parinaud's oculoglandular syndrome in a patient scratched by a cat six and a half months previously and who gave a positive result to an antigen test for cat scratch disease. In conjunctival swabs were also found urticarial hairs, tracheal fragments, processionary caterpillar oenocytes, and a grain of pollen. The pathogenic part played by each of these foreign bodies is discussed, as well as the possibility of the oculoglandular syndrome being due to the reactivation of a latent virus, the organism of cat scratch disease. So far as we know, this work provides the first description of the association of ophthalmia nodosa with the oculoglandular syndrome of Parinaud.

Animals↗
PubMed1985

[An oculoglandular syndrome and ophthalmia nodosa].

A case of ophthalmia nodosa associated with an oculoglandular syndrome is described. The patient, scratched by a cat six-and-a-half months earlier, presented a positive cat-scratch disease antigen test. The possibility that the oculoglandular syndrome is due to the reactivation of a latent virus, the cause of cat-scratch disease, is discussed.

Cat-Scratch Disease↗
PubMed1981

[Retinal detachment].

Over the last few years there has been a further increase in the surgical treatment of the retinal detachment. Reapplication of the retina is now very often achieved immediately. Repeated intervention has become less common and operative methods less aggressive. This communication aims to give an idea of present concepts in the treatment of retinal detachment and to explain some surgical attitudes. It also recalls the importance of early diagnosis, as well as the examination methods and the prophylactic measures generally used. Some new ideas on the etiology of retinal detachment are also discussed.

Humans↗
PubMed1981

[Retinoblastoma, a curable tumor (author's transl)].

The retinoblastoma is one of the rare curable malignant tumors. Its diagnosis is usually simple, but the first signs are late in appearing and not always recognized. The reasons for delay in diagnosis are examined, and the clinical picture and treatment discussed.

Child↗