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Biomedical subjects

C G Schmidt

Publications and source records attributed to C G Schmidt.

At least 199 records · Page 11Linked to original sources
PubMed1978

Chromosome findings in effusions from patients with Hodgkin's disease.

Effusion cells from six patients with advanced Hodgkin's disease were studied. Even though no Hodgkin or Reed-Sternberg cells could be identified cytologically in five of the six cases, striking chromosome anomalies of a clonal nature, including a number of recurrent marker chromosomes, were demonstrated in all effusions. It is concluded that the effusion cells with abnormal karyotypes were intimately related to the pathogenesis of Hodgkin's disease.

Ascitic Fluid↗
PubMed1978

[Chemotherapy in Hodgkin's disease (author's transl)].

The chemotherapy in its systemic form should be reserved for advanced Hodgkin's disease, i.e. stages III B and IV, but it deserves consideration even for stage II B if B-symptoms are prominent. The following problems will be discussed: 1. Monotherapy or combination chemotherapy? 2. Simultaneous or sequential drug application in case of combined chemotherapy? 3. Continuous application or intermittent therapy? 4. Maintenance therapy or unmaintained remission? 5. Use of chemotherapy in early stages too? 6. Use of combined modality approach (chemo-/radiotherapy) with regard to the stage of the disease? Some combination chemotherapy regimens (MOPP, ABDV) as well as sequential drug application in case of treatment failures will be discussed . Hazards of a complete course of chemotherapy following total nodal irradiation or total nodal irradiation following such combination chemotherapy are mentioned. If the radiation dose is reduced, the combined modality approach might still improve results of treatment. Finally some new drugs in development for treatment of resistant disease are introduced.

Antineoplastic Agents↗
PubMed1977

Cystostatic efficacy of DNA-complexes of adriamycin, daunomycin, and actinomycin D. II. Comparative in vivo studies in an Ehrlich-ascites tumor.

The cytostatic efficacy of the antibiotics adriamycin, daunomycin and actinomycin D and of DNA-complexes of these compounds was compared in an Ehrlich ascites tumor in vivo. Various doses of the individual drugs and their DNA-complexes were injected intraperitoneally into female NMRI mice following 8 days after inoculation of 10(6) Ehrlich ascites cells. Survival analyses of animals demonstrated that by addition of DNA therapeutic indices were improved for adriamycin, daunomycin and actinomycin D, DNA alone had no effect on this tumor. Since earlier biochemical data (Seeber et al., 1977) had shown decreased in vitro cytotoxicity of DNA-bound antibiotics, this increase in therapeutic efficacy is probably due to an altered pharmacological behaviour after complex formation with a prolongation of effective intraperitoneal drug levels and decreased systemic toxicity.

Animals↗
PubMed1977

[Primary and secondary exploratory laparotomy and splenectomy in Hodgkin's disease (author's transl)].

Exploratory laparotomy with splenectomy was performed on 275 patients with hisologically confirmed Hodgkin's disease. In 188 patients the laparotomy was a primary one to determine more precisely the state of the disease. A secondary laparotomy was performed in 87 patients 1-12 years after diagnosis and radiotherapy. In 17.5% of patients the state had to be revised after laparotomy with splenectomy. In 38 the disease had further progressed, while in ten it had slighty regressed. In four cases clinical stage I proved to be stage III. Even prognostically more favourable forms may have progressed at first diagnosis. There was no correlation between B-symptoms and histological type, but there was between B-symptoms and spread of the disease. Calculated spleen weight provided no clue as to spleen involvement. There was no clear relationship between spleen involvement and histological subclassification. Risk-effect analysis indicate that laparotomy with splenectomy was useful because it makes optimal treatment possible.

Adult↗
PubMed1977

[On the problem of praetherapeutic sensitivity testing of human tumours based on incorporation studies of nucleic acid precursors in vitro (author's transl)].

Praetherapeutic sensitivity tests of human solid tumours based on incorporation studies of nucleic acid precursors have been described by various authors. This review intends to show that such tests may only be of rather limited value for the design of individual chemotherapeutic regimens. In many drugs, a correlation between biochemical and clinical effects has not yet been established. The reliability of praetherapeutic sensitivity tests is further impaired by general methodological difficulties of short-term cultures, individual pharmacology and toxicology of cytostatic agents as well as pharmacological and biochemical drug interactions in combination chemotherapy. Praetherapeutic testing with individual cytostatic drugs is discussed.

Alkylating Agents↗
PubMed1977

[The effect of radiotherapy on various immunological features in genital and breast carcinoma (author's transl)].

Lymphocyte transformation under phytohaemegglutinin (PHA), spontaneous rosette formation and immunoglobulin concentration were measured in women with genital or breast carcinoma. It was found that (1) DNA synthesis of lymphocytes under PHA was normal in women with stage I and II cervical carcinoma, slightly decreased in stage III; (2) DNA synthesis of lymphocytes under PHA was slightly but significantly decreased in untreated patients with breast carcinoma; (3) after radiotherapy, both for cervical and body of the uterus carcinoma, there was a significant decrease of PHA-stimulated DNA synthesis of lymphocytes compared with healthy females and with patients at the same stage of tumour spread not treated by radiotherapy; (4) there was no significant difference in spontaneous rosette formation between radiated patients with cervical or breast carcinoma, on the one hand, and healthy controls and non-radiated patients, on the other; (5) IgG levels were slightly but significantly decreased in patients with ovarian carcinoma while in cervical, breast and body of the uterus carcinoma they were normal, IgA and IgM levels were significantly raised.

Breast Neoplasms↗
PubMed1977

[CNS complications and their prevention in malignant non-Hodgkin's lymphoma (author's transl)].

Among 334 patients (aged 15-57 years) with malignant non-Hodgkin's lymphoma there were 14 who developed CNS complications, none in 144 with lymphoma of low malignancy. Lymphoblastic lymphoma predominated amoung those with CNS involvement. In adults with this form treatment should therefore be undertaken to prevent such complications. The study confirms the need for histological subclassification in malignant non-Hodgkins's lymphoma.

Adolescent↗
PubMed1977

[Clinical features of malignant follicular non-Hodgkin's lymphoma (author's transl)].

75 cases treated between 1970 and 1976 for malignant follicular non-Hodgkin's lymphoma were analysed for their cardinal signs. Contrary to non-Hodgkin's lymphoma of "higher malignancy degree", the average age of patients with malignant follicular non-Hodgkin's lymphoma is generally over 50 years, being more common in females. By the time the diagnosis is made a generalised stage has usually been reached. In the described group of patients the five-year survival rate was 65%, but compared with the malignant lymphoma of higher malignancy the prognosis is often complicated by secondary diseases resulting from the higher age. The findings confirm the need for histological sub-classification of malignant non-Hodgkin's lymphoma.

Adult↗