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Biomedical subjects

C G Nilsson

Publications and source records attributed to C G Nilsson.

16 recordsLinked to original sources
PubMed1979

Detection of beta subunit HCG in plasma of IUD users as an indication of frequency of conception.

One hundred and two women using an intrauterine copper device (Cu IUD) were studied for determination of HCG in blood plasma specimens obtained during the last 5 days of the menstrual cycle. HCG, LH, and progesterone were measured by radioimmunoassay (RIA). Two positive HCG values were found, indicating conception. The methods by which the frequency of fertilization during IUD use can be evaluated are discussed.

Adult↗
PubMed1978

Sustained intrauterine release of d-norgestrel.

Clinical experience with seventy-two first insertions of a d-norgestrel-releasing IUD is reported. Plasma d-norgestrel concentrations were measured in twelve subjects. No pregnancies occurred in the 522 woman-months of use (averaging 7.3 months/subject) that have been accumulated. Removals were performed in six subjects for medical reasons and in seven subjects for personal reasons. Plasma concentrations of d-norgestrel were highest during the first two weeks of use. A decline in the plasma concentration of d-norgestrel occurred and was only 0.05 ng/ml between 30 and 90 days after insertion.

Adult↗
PubMed1978

Determination of plasma concentrations of d-norgestrel during a one year follow-up in women with a d-norgestrel-releasing IUD.

Eight healthy women had a d-norgestrel-releasing intrauterine device inserted postmenstrually and maintained in the uterine cavity for a one year period. Plasma concentrations of d-norgestrel were measured by radioimmunoassay during the one year treatment period. d-Norgestrel could be detected in the plasma of all the subjects within a fairly narrow range during the whole period. The release rate of d-norgestrel was calculated from two IUDs removed after the treatment.

Adult↗
PubMed1978

Endometrial morphology of women using a d-norgestrel-releasing intrauterine device.

Endometrial biopsies were obtained from 12 volunteers treated with d-norgestrel-releasing intrauterine devices (IUDs) with two different release rate. Four subjects scheduled for hysterectomy had d-norgestrel-releasing IUDs inserted approximately 1 month prior to surgery. The effect of d-norgestrel on the endometrium and fallopian tubes of the removed uteri was examined. A uniform suppression of the endometrium with glandular atrophy and decidualization of the stroma was found in all of the endometrial specimens. Moreover, changes similar to those observed during the luteal phase and early pregnancy could be seen in the tubal epithelium.

Adult↗
PubMed1978

Plasma prolactin concentrations in women treated with low dose combination type oral contraceptives and in women using a d-norgestrel-releasing intrauterine device.

Plasma prolactin was measured in fourteen fertile women during a control cycle and during treatment with two different types of contraception. Ten of the women received a low dose combination type oral contraceptive, while the other four had a d-norgestrel-releasing intrauterine device (d-Ng-IUD) insereted. Plasma samples were corrected in the follicular and luteal phases during the control cycle and the treatment cycles in the d-Ng-IUD-group. In the oral contraceptive group, the samples were collected before treatment, three weeks, and again three months after the beginning of treatment. The results in the different grolups and the different phases of the cycles were compared, but no significant differences were found.

Adult↗
PubMed1975

Biodegradable polylactate as a steroid-releasing polymer: intrauterine administration of d-norgestrel.

Polylactate film containing 30 per cent or 4.5 mg. of d-norgestrel was fixed around a plain T-IUD and the device was inserted into the uterine cavity. Norgestrel was gradually released into the systemic circulation, blood levels being highest during menstruation. Plasma estradiol and progesterone determinations revealed that cyclic ovarian function was maintained during the intrauterine administration of norgestrel; however, marked local effects on the endometrium resulted. The amount of menstrual bleeding was reduced.

Adult↗