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Biomedical subjects

C G Mathias

Publications and source records attributed to C G Mathias.

10 recordsLinked to original sources

Contact dermatitis and gastrointestinal symptoms from hydroxyethylmethacrylate.

A laboratory technician developed allergic contact dermatitis to hydroxyethylmethacrylate associated with nausea, diarrhoea and persistent paresthesiae of the fingertips. The gastrointestinal symptoms were reproduced by patch testing. Hydroxyethylmethacrylate was demonstrated to pass through vinyl gloves. Cross reactions occurred to methyl-, ethyl-, propyl- and isopropylmethacrylate but not to butyl- or isobutylmethacrylate.

Acrylates

Pityriasis rosea in a patient with epidermolysis bullosa dystrophica.

A patient with clinical and histologic features of epidermolysis bullosa dystrophica-recessive (EBD-R) developed superimposed clinical lesions of pityriasis rosea (PR). Electron microscopy showed distinct "blebbing" of basal cells at the basement membrane zone in clinically normal skin of a non-predilected area, as well as in scarred skin from a predilected area and a lesion of PR. An increased susceptibility of the basement membrane zone to proteolytic enzymes is suggested as a possible hypothesis to explain these observations.

Adult

Delayed hypersensitivity to retrobulbar injections of methylprednisolone acetate.

A patient with chronic cyclitis developed hyperemia of the episcleral and bulbar conjunctival vessels after retrobulbar injections of methylprednisolone acetate suspension. Intradermal testing revealed the responsible allergen to be methylprednisolone acetate; hypersensitivity could not be demonstrated by patch testing, despite use of increased concentrations.

Adult

Allergic contact photodermatitis to para-aminobenzoic acid.

Allergic photocontact dermatitis developed in a patient to a commercial sunscreen preparation containing para-aminobenzoic acid (PABA) in an alcohol base. Photopatch testing showed photosensitivity to PABA. Sensitization could only be detected when PABA was tested in an alcohol vehicle; a photopatch test to PABA in petrolatum was negative.

4-Aminobenzoic Acid