Search PubMed⌕ Search

Biomedical subjects

C G Clark

Publications and source records attributed to C G Clark.

At least 181 records · Page 10Linked to original sources

Lipodystrophy, pancreatitis, and eosinophilia.

Two patients suffering from partial lipodystrophy, pancreatitis, and recurrent eosinophilia are described. In one patient the duodenum and the terminal ileum were narrowed, the appearances suggesting eosinophilic gastroenteritis: bilateral hydronephrosis was also present without ureteric obstruction. An association between lipodystrophy and renal disease is recognized; it is possible that there is also an association between lipodystrophy and pancreatitis, and eosinophilia with or without an intestinal lesion may be a further association.

Adult↗

Conditioned response-contingent delays of the unconditioned stimulus in human aversive conditioning.

Four groups of subjects were given either 0. 100, 500, or 1,000 msec delays of the unconditioned stimulus (UCS) contingent upon the occurrence of a conditioned response (CR) and were given a UCS 515 msec after conditioned stimulus (CS) onset when a CR did not occur. A fifth group received standard classical conditioning trials with an interstimulus interval of 515 msec. Overall performance decreased as CR-contingent UCS delay increased, with the classical conditioning group approximating the performance of the group receiving the 100-msec delay. The data were analyzed with the two-phase model of conditioning and the following results were obtained: The duration of Phase 1 of the model increased with contingent delay; operator limits associated with CR trials or with combined CR-CR (CR absent) trials decreased as a function of delay; and operator limits associated exclusively with CR trials were unaffected by the delay. Subjects receiving a contingent delay of 0 msec gave the shortest latency responses and exhibited reliable latency decreases across trials, suggesting an attempt to "beat" the UCS. The results were interpreted as contrary to what would be expected from low-of-effect theories which postulate that reinforcement results from a CR-UCS interaction, although they could be subsumed under a drive or an associative strength theory in which the aversive, or CR-supportive, strength of the UCS is assumed to be negatively correlated with contingent UCS delay.

Adult↗

Gastric acid secretion and diagnosis of Zollinger-Ellison syndrome.

One hundred and fifty patients suspected of having Zollinger-Ellison syndrome were investigated. High plasma gastrin levels were found in 23 and in 16 a diagnosis of Zollinger-Ellison syndrome was confirmed. Measurement of the basal and maximal acid outputs showed that these simpler investigations have considerable value as screening tests for the selection of those patients in whom gastrin studies are indicated.

Gastric Juice↗

Effect of proximal gastric vagotomy on gastric acid secretion and plasma gastrin.

Sixteen patients underwent proximal gastric vagotomy (highly selective vagotomy) for chronic duodenal ulceration. All were subjected to preoperative and postoperative acid secretion studies. A reduction in the secretory response to pentagastrin and abolition of the response to meat extract occurred postoperatively. Plasma gastrin levels in response to meat extract were studied by radioimmunoassay. Basal plasma gastrin levels were unaffected by vagotomy and it was found that the plasma gastrin response to meat extract was not impaired after operation if the postoperative insulin test was positive. Only if the insulin test was negative was the amount of gastrin released by meat extract reduced.

Duodenal Ulcer↗