Glucose tolerance and insulin secretion were studied in 15 male patients suffering from muscular dystrophies. Creatinine excretion was used as a measure of functioning muscle mass. The decrease in glucose tolerance correlated significantly with the injury of muscular efficiency. Despite impaired glucose tolerance, very high levels of circulating insulin were reached, as in obese diabetics. The observations do not simply reflect the decrease in distribution volume of glucose. They can be explained by an altered proportion of muscle mass to adipose and connective tissue. Decreased glucose tolerance may signalize the myopathic reaction following an endocrine disorder or a malignant disease.

Adolescent↗

PubMed1979

[Muscular weakness and creatinine excretion (author's transl)].

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Adult↗

PubMed1978

[Glucose tolerance and neurogenic muscular atrophies (author's transl)].

Glucose tolerance is reduced in patients suffering from neurogenic muscular atrophies. In a group of 20 patients with myatrophic lateral sclerosis the extent of atrophy correlated significantly with the decrease in glucose tolerance. Creatinine excretion was used as a measure of functioning muscle mass. Insulin secretion was not reduced, on the contrary, it was strongly pronounced in these cases. The observations are not explained by a decrease in distribution volume of glucose. By testing glucose tolerance, functions of sceletal muscles are examined at the same time. In evaluating the results, the functioning muscle mass has to be taken into account.

Adolescent↗

PubMed1978

[Cardio-circulatory effects of aminophylline (Euphyllin) (author's transl)].

In 24 patients with congenital or acquired heart disease, functional class II--IV New York Heart Association Classification, effects of aminophylline on hemodynamics have been investigated intraoperatively, during extracorporeal circulation and postoperatively. Aminophylline caused a decrease in arterial pressure, left ventricular pressure, right and left atrial pressure, total systemic resistance and total pulmonary resistance. At the same time there was an increase in heart peak, peak dp/dt, cardiac index and stroke index. Our results demonstrate beneficial cardiac and extracardiac effects of aminophylline in man.

Adult↗

PubMed1978

[Effects of calcium gluconate and calcium chloride on cardiocirculatory parameters in man (author's transl)].

In 44 patients with congenital or acquired heart disease, functional class II--IV NYHAC, the effects of calcium gluconate (10 ml 10%) and calcium chloride (10 ml 5.5%) on hemodynamics, inotropy and myocardial oxygen consumption were investigated during and immediately after cardiosurgical procedures. There was a significant increase in blood pressure, left ventricular pressure, total systemic resistance, cardiac index, stroke index, peak dp/dt and myocardial oxygen consumption as well as in arterial perfusion pressure during extracorporeal circulation due to i.v.-injection of either one of the drugs. The positive inotropic effects were more pronounced after application of calcium chloride. In emergency situations during anaesthesia or resuscitation, therefore, calcium chloride seems to be of more advantage than calcium gluconate.

Calcium Chloride↗

PubMedDate not supplied

Management of patients with airway obstruction.

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Airway Obstruction↗