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Biomedical subjects

C Frank

Publications and source records attributed to C Frank.

At least 181 records · Page 10Linked to original sources
PubMed1984

[Microbiological studies of ground water polluted with hydrocarbons. 1. Quantitative and qualitative distribution of bacterial populations].

The groundwater, polluted with hydrocarbons, showed large cell numbers during one year of examination: 10(3)-10(4) CFU/ml grown on N-agar after 5 days at 20 degrees C, 10(4)-10(5) CFU/ml grown on water-agar after 8 weeks at 20 degrees C and total cell numbers of 10(5)-10(7)/ml. The bacteria, which were isolated from N-agar, were chiefly Pseudomonas, Flavobacterium, Acinetobacter, and other gramnegative species, Arthrobacter and Bacillus as members of grampositive bacteria. Furthermore the following "physiological' groups were found in the groundwater: ammonium-oxidizing bacteria (MPN 10(1)-10(2)/ml), sulfur-oxidizing bacteria (MPN 10(1)-10(4)/ml), nitrate-reducing bacteria (MPN 10(3)-10(6)/ml), denitrifying bacteria (MPN 10(1)-10(4)/ml), spores of aerobe spore-forming bacteria (2-30/ml), spores of anaerobe spore-forming bacteria (0.2-0.4/ml), manganese-oxidizing bacteria (10(3)-10(4) CFU/ml) and Actinomycetes (0.1-1.0 CFU/ml).

Acinetobacter↗
PubMed1984

Physiology and therapeutic value of passive joint motion.

Despite the long history of therapeutic experience with different types and amounts of passive joint motion, its effects and the principles of its use remain controversial. Through empiric success, a spectrum of passive motion has evolved for various clinical purposes, including joint diagnosis; correction of joint deformities; mobilization of stiff joints; stimulation of joint healing; neuromuscular re-education; and prevention of immobilization complications (e.g., contracture formation, connective tissue atrophy, relative healing inhibition, and associated stasis abnormalities). However, the potential abuses of passive motion (e.g., causing additional tissue trauma, mobilizing unprotected joints, and stretching the wrong joints or tissues) have created serious doubts as to the value of this therapy and raised important questions concerning the lack of proper definition (e.g., force, direction, speed, and duration) and the unknown margins of safety. Clinical and experimental evidence supports the probable effectiveness of passive joint motion on joint and tissue levels, but without a better quantitative understanding of the mechanisms of action, dose-responsiveness, specific tissue effects, and, most important, their controls. Thus, passive motion will continue to be used suboptimally with inconsistent results. When these clinical and research deficiencies are corrected, passive motion will attain its proper place as a powerful and reliable orthopedic tool.

Connective Tissue↗
PubMed1983

Interactions between amino acid neurotransmitters and flurazepam in the neocortex of unanesthetized rats.

The effects induced by the benzodiazepine flurazepam (FLU) upon neuronal responses to glutamic acid (GLUT), gamma-aminobutyric acid (GABA), and glycine (GLY) were studied in the cortex of unanesthetized rats using single-unit extracellular recordings in conjunction with iontophoretic techniques. The application of FLU (5-20 nA) did not affect excitatory responses to GLUT, but the spontaneous firing rate was depressed by equivalent doses of this benzodiazepine. A selective increase of GABA, but not of GLY-induced responses was seen when either low currents (5-10 nA) of FLU or GLUT driving currents were used to study the neuronal responses of the inhibitory amino acids upon steady neuronal firing. Our data demonstrate that in unanesthetized animals FLU does not affect GLUT-induced effects while it selectively increases GABA-mediated inhibition.

Amino Acids↗
PubMed1983

Natural history of healing in the repaired medial collateral ligament.

The purpose of this study was to assess morphologically the healing of repaired medial collateral ligaments (MCLs) in a rabbit model. Healing ligaments were examined grossly and histologically at various intervals, from 3 days to 2 1/2 years after injury, and compared with the appearances of normal age-, sex-, and activity-matched controls. Results show that all ligaments healed by bridging scar formation rather than true ligament regeneration. Increases in cellularity and temporary matrix disorganization along the entire length of the ligaments during healing suggest a combination of diffuse mechanical damage from their failure in tension and regional inflammatory injury (in excess of surgical exposure alone) from the processes of degradation and replacement. Substance that was not injured physically in this model demonstrated complete recovery, while that replaced by scar did not. Healing processes were similar to those of other highly specialized soft tissues (e.g., tendons), with short phases of hemorrhage and inflammation, an intermediate phase of proliferation, and a prolonged phase of remodeling. Failure of repairs to maintain anatomical apposition of torn ends may have contributed to the delay of these healing processes by increasing scar mass. Incomplete scar remodeling at 2 1/2 years, however, suggests much slower MCL healing than previously reported and probably, therefore, a longer period for potential treatment influence.

Animals↗
PubMed1983

Healing of the medial collateral ligament of the knee. A morphological and biochemical assessment in rabbits.

Complete midsubstance injuries of medial collateral ligaments of matched New Zealand white rabbits were allowed to heal without repair or immobilization for various lengths of time. Morphological and biochemical parameters were used to evaluate healing as compared with normal unoperated and sham operated ligaments. Results showed incomplete healing at the longest term follow-up (14 weeks) with significant biochemical abnormalities. Although there was a trend toward normal, recovery from injury was much slower than previously reported.

Animals↗
PubMed1983

Electromagnetic stimulation of ligament healing in rabbits.

To evaluate the effect of a specific noninvasive method of electrical stimulation on ligament healing in rabbits, a solid core electromagnet energized by a square wave unidirectional current was applied to injured and repaired medial collateral ligaments seven hours per day, five days per week for intervals of up to six weeks. Healing was evaluated by gross, histologic, biochemical, and biomechanical parameters. Stimulation was shown to increase histologic maturity relatively, restore stiffness and failure strength earlier, and return collagen content toward normal unoperated values sooner in these healing ligaments. It is uncertain whether the end point of healing is affected by this technique, but at six weeks both histologic and biochemical evidence of acceleration remains. Further investigation into the effect of electromagnetic stimulation by this and other fields on non-osseous tissues and their components is indicated.

Animals↗
PubMed1982

A computerized study of knee-ligament injuries: repair versus removal of the torn anterior cruciate ligament.

A retrospective review of 202 patients with acute injury to knee ligaments was carried out by chart review, scored questionnaire and scored physical examination. Of 62 patients with complete midsubstance injury to the anterior cruciate ligament, repair was attempted in 46, while 16 had complete excision of the ligament without replacement or augmentation. Computer analysis revealed that these groups were similar with respect to mean age of the patients, sex distribution, incidence of meniscectomy and distribution of associated injuries. At 4-year follow-up, there was no advantage of primary repair over excision for these injuries. In fact, repair seemed to be subjectively and objectively worse than excision, being associated with increased pain and decreased range of motion. The high rate of signs and symptoms of deterioration in both groups suggests a need for better alternatives in the acute phase of anterior cruciate ligament injury.

Adolescent↗
PubMed1980

[Persistent forty-eight hour cycle in a case of manic-depressive psychosis-chromopathological aspects (author's transl)].

Connections between psychopathological symptoms and chronobiological factors are discussed in the light of a bipolar manic-depressive illness in a female patient suffering during several years from a cycle of 24 hours of depression alternating with one day of hypomania. The forty-eight hour periodic psychosis was evoked by a severe cerebral trauma. All over the world there is only a small number of patients with such regular psychotic cycles. They present a good opportunity to study a conceptual model of desynchronization in phasic psychiatric disorders implying the hypothesis of disturbance of the time structure of functions resulting in a psychotic state.

Aged↗
PubMed1980

Quantitative epidemiological studies on the prevalence of babesiosis in horses in Kuwait.

Racehorses imported into Kuwait were tested for serum antibodies to Babesia equi and B. caballi by complement fixation (CF) and indirect fluorescent antibody (IFA) tests. The prevalence of B. equi was high (77.1% by IFA) whereas that of B. caballi was much lower (11.4%). Data for B. equi showed that infection was acquired after about 6 months at risk and that in the following 12 months animals had antibody levels detectable by both CF and IFA tests by 24 months the CF reaction was no longer detectable. Estimates of incidence and inoculation rates were calculated and found to be consistent with a considerable infection pressure.

Animals↗
PubMed1978

[Protozoa of small mammals in the Neusiedlersee region].

During the years 1975 and 1976, 169 mammals (26 species) were investigated for their parasites. It was possible to recognise 33 different species of protozoans, belonging to the following genera: Trypanosoma, Giardia, Hexamita, Entamoeba, Eimeria, Isospora, Toxoplasma Frenkelia, Hepatozoon, Babesia, Balantidium, Pneumocytis, Grahamella, Eperythrozoon.--Epidemiology and eventual pathogenic effects are briefly discussed.

Animals↗
PubMed1977

[Additional observations to the biology of Hepatozoon erhardovae Krampitz 1964 in bank voles from the south-western Styria and from areas around the Neusiedlersee (Burgenland) (author's transl)].

The incidence of Hepatozoon erhardovae in the blood of bank voles (Clethrionomys glareolus) captured in the investigated areas is examined. The biology of schizonts, their distribution in the lobes of the lung and the further development of natural infections in vertebrate hosts kept strictly free of ectoparasites are observed. The accumulation of gametocytes in larvae of the tick Ixodes ricinus and of the mite Neotrombicula zachvatkini after sucking on strongly infected bank voles is pointed out. Occasionally a parasitaemia is produced in the non-specific host (Apodemus flavicollis), but only with a specific transmitter (Megabothris turbidus).

Animals↗
PubMed1977

[The importance of Laelaps agilis C.L. Koch 1836 (Mesostigmata: Parasitiformae) as a vector of Hepatozoon sylvatici Coles 1914 (Sporozoa: Haemogregarinidae) (author's transl)].

The importance of the mite Laelaps agilis (Parasitiformae) for the transmission of the Hepatozoon species living in the blood of Apodemus sylvaticus and Apodemus flavicollis (Hepatozoon sylvatici) is examined. With this mite the experimental transfer of the parasite to bred hosts of the same species was successful five times; for once, the transmission to a non-specific host (Clethrionomys glareolus) was also possible. Besides, an eventual stimulating effect emanating from the gonads of female mites to the development of parasites can be considered. Differences in the morphology of schizonts in the bone marrow and in the liver of infected Apodemus flavicollis are especially pointed out.

Animals↗
PubMed1977

[Small mammal helminths in Neusiedlersee region].

153 small mammals belonging to 22 species were investigated during the year 1975. On this occasion, 29 different species of helminths were found. Parallel-infection of one host by different helminths was common. All age-groups and both sexes of hosts were infested. Pathological symptoms like eosinophile infiltration of the lungs and splenomegalia were generally observed as accompanying phenomena of endoparasitic infestations. Often, there were no distinct symptoms even if the intensity of the infection was comparatively high. Minor infections may pass without clinical phenomena. Amongst the investigated hosts Hymenolepis diminuta, Cyticercus fasciolaris (larva of Hydatigera taeniaeformis), Strongyloides ratti and Hepaticola hepatica were the most widespread species of helminths.

Animal Population Groups↗