Biomedical subjects

C Franceschi

Publications and source records attributed to C Franceschi.

365 records · Page 21Linked to original sources

PubMedDate not supplied

Prostaglandins and cyclic nucleotides as effectors in non-lymphocyte mediated surveillance processes ( short review).

This paper reviews the evidence pointing to a role of prostaglandins and cyclic AMP in the regulation of surveillance processes against transformed cells carried out by activated monocytes macrophages and natural killer (NK) cells. Specific topics of discussion include: (a) the regulation of monocyte/macrophage system and NK cells by prostaglandins and cyclic AMP; and (b) the possible immunomodulatory role of thromboxanes generated by activated monocytes and macrophages. Also the role of cyclic AMP dependent and independent protein kinases as well as their link with oncogenes is briefly reviewed.

Cell Division↗

PubMedDate not supplied

Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously.

Rat thymocytes were stimulated with phytohaemagglutinin (PHA), Concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS) or with mixtures of two of these mitogens, added simultaneously to in vitro cultures. Four-five concentrations of first mitogen were matched with four-five concentrations of second mitogen, in all possible combinations. Synergistic effects were observed with LPS plus PHA and LPS plus PWM and inhibitory effects with PHA plus Con A and LPS plus Con A. The hypothesis is discussed that an inhibitory effects occurs when two mitogens react with identical or very similar receptors on the lymphocyte surface, while a synergistic effect is produced by two mitogens reacting with different receptors.

Animals↗

PubMedDate not supplied

[The Doppler in everyday phlebology].

Besides the sophisticated Doppler examination requiring a large and fairly expensive apparatus, it is possible to use a Doppler apparatus which is cheap, light, non-directional, has no recording device, and delivers only the sound signal; this is practical and easy to use, but its limitations must be strictly understood. This everyday Doppler apparatus can be used for the recognition of acute occlusions of the large deep venous trunks, as well as valvular incompetences, superficial and especially deep. It cannot be used for the recognition of well compensated occlusions, nor of partial obliteration of the large trunks or total obliteration of the small trunks; these diagnoses require the more sophisticated Doppler examination, but in these restricted cases it will often be better to carry out phlebography, which is a more reliable investigation in these limited conditions.

Doppler Effect↗

PubMedDate not supplied

DNA repair after UV and gamma irradiation. I. Rat spleen cells.

An in vitro microculture was set up to standardize DNA enzymatic repair in rat spleen lymphocytes after exposure to ultraviolet or gamma rays by measuring the tritiated thymidine uptake. A relation between irradiation dose and DNA repair is always observable when cell viability and scheduled DNA synthesis are taken into account. This micromethod utilizing rat spleen cells appears to be a suitable system for such a study since it permits a satisfactory evaluation of DNA repair.

Animals↗

PubMedDate not supplied

DNA repair after UV and gamma irradiation. II. Human lymphocytes.

A technique of an in vitro microculture system has been set up in order to standardize DNA repair in adult human lymphocytes after ultraviolet and gamma irradiation measuring tritiated thymidine uptake. The results obtained in DNA unscheduled synthesis were different if ultraviolet or gamma rays were employed.

Cells, Cultured↗