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Biomedical subjects

C Fisher

Publications and source records attributed to C Fisher.

At least 451 records · Page 25Linked to original sources
PubMed1981

Variations in plasma concentrations of alpha-melanocyte-stimulating hormone during the oestrous cycle of the rat and after administration of ovarian steroids.

Plasma concentrations of alpha-melanocyte-stimulating hormone (alpha-MSH) were measured by radioimmunoassay at various times during the oestrous cycle of the rat. Variations in plasma alpha-MSH concentrations occurred throughout the oestrous cycle. Plasma alpha-MSH concentrations were low during the day of dioestrus 1 and rose during the evening reaching peak levels at around 02.00 and 06.00 h on dioestrus 2. Plasma alpha-MSH concentrations then fell and remained low throughout the rest of dioestrus 2. A different pattern was observed during pro-oestrus and oestrus. On those days peak alpha-MSH concentrations occurred during the morning and persisted until the onset of the dark period at around 17.00 h. Plasma alpha-MSH concentrations in ovariectomized rats were found to be increased 24 h after administration of a single injection of oestradiol benzoate and at 12 and 36 h after a single injection of progesterone. It is suggested that these ovarian steroids may influence the rhythm in plasma alpha-MSH concentration that occurs during the oestrous cycle.

Animals↗
PubMed1981

Immunologic heterogeneity of the folate-binding proteins from chronic myelogenous leukemia cells and myelofibrosis spleen.

An FBP has been purified from the spleen (FBP-S) of a patient with agnogenic myeloid metaplasia and myelofibrosis. This binder is similar to a previously purified protein from CML cells (FBP-L) in its molecular weight and affinity for folate analogues. However, each protein has very little cross-reactivity in specific RIAs for each binder, indicating that there are structural differences which can be detected by the immune system. THe concentration of FBP-L in the serum from normal subjects was 2.0 +/- 0.39 ng/ml (mean +/- S.E.M.) and was significantly elevated in the serum from some patients with CML, uremia, hepatitis, and cancer. The concentration of FBP-S, on the other hand, was 8.31 +/- 0.51 ng/ml in normal serum and remained in this range in the same serum that contained the elevated concentration of FBP-L. In contrast, the concentration of FBP-L was only 13% to 30% of the concentration of FBP-S measured in the homogenates of normal and adjacent cancerous tissue from lungs and colons. These studies indicate that some FBP(s) in human tissues have immunologic specificity even though they are functionally similar.

Antigen-Antibody Complex↗
PubMed1980

Production of pseudodiabetic renal glomerular changes in mice after repeated injections of glucosylated proteins.

Plasma proteins glucosylated in vitro were injected repeatedly into 7 mice. A group of 4 was given multiple injections of non-glucosylated plasma proteins and another 10 were untreated. 5 of 7 mice given glucosylated proteins had glomerular-basement-membrane thickening on electron microscopical examination. This feature is characteristic of human and experimental diabetic renal disease. These results suggest that there may be a link between plasma-protein glucosylation and diabetic nephropathy.

Animals↗
PubMed1980

Tooth induction in chick epithelium: expression of quiescent genes for enamel synthesis.

Intraocular grafts of chick epithelium combined with mouse molar mesenchyme produced a variety of dental structures including perfectly formed crowns with differentiated ameloblasts depositing enamel matrix. The results suggest that the loss of teeth in Aves did not result from a loss of genetic coding for enamel synthesis in the oral epithelium but from an alteration in the tissue interactions requisite for odontogenesis.

Amelogenesis↗
PubMed1980

Changes in plasma, pituitary and brain alpha-MSH content in rats from birth to sexual maturity.

Immunoreactive alpha-MSH was measured in plasma, pituitary and brain of male and female rats on the day of birth and at intervals afterwards up to 55-70 days of age. Plasma alpha-MSH concentrations on the day of birth were 528 +/- 111 pg/ml and 406 +/-167 pg/ml in female and male rats, respectively. Plasma alpha MSH concentrations then fell and remained low until the onset of sexual maturity when they again rose reaching 406 +/- 38 pg/ml in 70 day old females and 312 +/- 46 pg/ml in 55 day old males. Pituitary alpha-MSH concentrations also changed with age and in male rats generally reflected the changes in plasma alpha-MSH concentrations. In females, on the other hand, pituitary alpha-MSH concentrations showed a gradual increase with age. Concentrations of alpha-MSH in the hypothalamus and brain increased with age and as with plasma and pituitary reached peak values in sexually mature animals. These findings are consistent with the idea that both pituitary and brain alpha-MSH have a role in sexually mature rats. Although alpha-MSH may have a role in sexual behaviour there was no evidence of any change in brain alpha-MSH throughout the estrous cycle.

Aging↗
PubMed1980

Pseudolymphoma of the lung: a rare cause of a solitary nodule. A case report and review of the literature.

Pulmonary pseudolymphoma is a rare lesion; only 30 cases have been previously reported. It presents as a solitary nodule which clinically and roentgenographically can resemble bronchogenic carcinoma. A further case is reported in which preoperative needle aspiration cytology played a role in diagnosis. Although the lesion was originally believed to be benign, a review of the literature has revealed the apparent subsequent development of lymphoma in four cases. The significance of this is discussed, and the need for prolonged follow-up is emphasized, since the prognosis of untreated pseudolymphoma is unknown.

Biopsy, Needle↗
PubMed1979

Evaluation of nocturnal penile tumescence in the differential diagnosis of sexual impotence. A quantitative study.

Nocturnal penile tumescence (NPT) was assessed in 30 impotent patients for the purpose of differential diagnosis. In 11 psychogenic cases, with several exceptions, NPT was found to be normal, with a marked discrepancy between the NPT findings and the patients' estimates of their daytime erectile capacity. In 19 organic patients, maximal NPT corresponded closely to and mirrored the patient's subjective estimate of his impaired waking performance. Statistically, the figures for frequency, degree, duration, and amount of NPT were found to be significantly and markedly greater in the psychogenic group. Statistical significance was maintained when the 11 psychogenic patients were closely age-matched with 11 of the 19 organic cases. The method is not 100% accurate; some 15% of impotent patients without organic findings have reduced NPT, several of whom were shown to be psychogenic, but others in this group may have undetected organic pathology. The NPT method is very promising, but beset by a number of methodological problems.

Adult↗