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Biomedical subjects

C Fiore

Publications and source records attributed to C Fiore.

At least 37 records · Page 2Linked to original sources
PubMed1991

Activating tasks for the study of visual-spatial attention in ADHD children: a cognitive anatomic approach.

The clinical label attention deficit hyperactivity disorder (ADHD) suggests that this syndrome is a disorder of attention. However, the presumed attentional deficits have not been linked either to specific cognitive operations or to specific neural systems. To provide this link, theories of the cognitive anatomy of attention were used to generate hypotheses about specific visual-spatial attentional deficits in children with ADHD. A cued reaction-time test was used to assess covert and overt shifts of attention theoretically linked to two neuroanatomically defined attentional systems in the posterior and anterior parts of the human brain. The early, posterior-based covert shift of attention was found to be normal in ADHD children, but a later, anterior-based overt shift of attention was abnormal as reflected by a significant lateral difference in reaction time. This was interpreted as a failure to sustain focused attention.

Analysis of Variance↗
PubMed1988

[Bone choristoma of the bilateral choroid and asymmetric microphthalmia].

The authors report a case of associated bilateral asymmetrical microphthalmia and osseous choristoma of the choroid in a seventeen year old young woman. This association, to the author's knowledge, has not been previously reported in the literature. The bone choristoma was present in the eye's posterior poles and the clinical features were studied by electroretinography, fluorescein angiography, A-B scan ultrasonography, computerized axial tomography and nuclear magnetic resonance. The authors hypothesize that a choroid developmental tumor was produced by exposure to the rubella virus during embryonic life.

Adolescent↗
PubMed1987

Associated retinitis pigmentosa and fundus flavimaculatus.

A family is described with 2 members, father and son, affected by associated retinitis pigmentosa and fundus flavimaculatus, whereas 1 other member had a combination of retinitis pigmentosa and unilateral central areolar atrophy, 1 member a fundus flavimaculatus with electroretinographic findings indicative of a subclinical form of retinitis pigmentosa and the last one with electroretinographic findings indicative of a subclinical form of retinitis pigmentosa.

Adult↗
PubMed1986

[Chorioretinal changes in the course of sympathetic ophthalmia].

A case of sympathetic ophthalmitis is reported. A bull's eye chorioretinopathy was observed with electroretinographic changes (augmentation of latencies and disappearance of oscillatory potentials) which regressed in a short time. The authors believe that the retinal changes could be secondary to an autoimmunological reaction, responsible for the sympathetic ophthalmitis.

Adolescent↗
PubMed1985

Recurring bilateral hypopyon in chronic myeloid leukemia in blastic transformation. A case report.

There have been many reports in the literature on keratohypopyon in acute leukemia. We report a case of a 40-year-old-man with chronic myeloid leukemia who developed bilateral, recurring kerato-hypopyon, the first manifestation of which appeared during intrathecal chemotherapeutic treatment just after an episode of leukemic meningiosis. There was no involvement of the CNS at the time of the relapse of kerato-hypopyon.

Adult↗
PubMed1985

Gammaglobulins and immunocomplexes in aqueous humor and serum of patients with senile cataract.

The authors have measured the gammaglobulins and the immunocomplex levels (CIC) in aqueous humor and serum of 14 patients (3 males and 11 females) over 50 years old, who were affected by different types of cataract. Even if the authors have examined a limited number of samples, the results confirm the previous data which also showed very low levels of IgG, IgA, IgM, IgE, CIC in aqueous humor.

Aged↗
PubMed1984

Efficacy of liposome-intercalated amphotericin B in the treatment of systemic candidiasis in mice.

We developed a liposome-intercalated preparation of amphotericin B by using small, unilamellar vesicles 0.06 to 0.1 micron in diameter. In contrast to previously described liposomal preparations of amphotericin B, these vesicles have the advantage that they are small enough to be filter sterilized. We compared the efficacy of liposomal amphotericin B with that of the commercial drug given as an intravenous bolus every other day for 13 days (seven doses) in mice with disseminated candidiasis. Survival rates were similar for the two preparations at each dosage of amphotericin B; however, the highest survival rates occurred at dosages of liposomal amphotericin B which would be lethal to these animals if administered as the commercial drug. Viable colony counts of fungi in various organs, particularly the kidneys, tended to be lower with increasing dosage of the drug. However, some organisms persisted even after 13 days. These studies indicate that liposomal formulations of amphotericin B merit further investigation because of their improved therapeutic margins.

Amphotericin B↗
PubMed1984

Hyperactive children: a study of the content analysis of their speech.

A group of hyperactive boys with attention deficit disorder (DSM-III) (n = 13) was compared to a group of normative, nonhyperactive boys (n = 16) with respect to Gottschalk-Gleser scores derived from 5-min speech samples they produced in response to standardized and purposely ambiguous instructions. The hyperactive boys had significantly higher mean scores than the normative boys for cognitive impairment, social alienation-personal disorganization, and total depression. Of the eight depression subscales, the hyperactive boys had significantly elevated scores on hopelessness, self-accusation (a cluster composed of shame, guilt, and hostility inwards), and psychomotor retardation. Problems with the classification of the hyperactive syndrome, which is equated with the attention deficit disorder, are briefly discussed. The present study gives some support to the concept, as adjudged from the content analysis of verbal behavior, that hyperactivity, at least in boys, may be associated with cognitive impairment, increased general psychiatric morbidity, and depression. Whether single or multiple etiological factors are involved in this disorder cannot be ascertained from this study.

Attention Deficit Disorder with Hyperactivity↗
PubMed1984

[Microangiopathy and retinal dystrophy].

Two cases are described of an association of retinal dystrophy and a vasculopathy similar to Coat's disease. The first case was a female adult in whom the two sets of symptoms appeared almost simultaneously. In the second case the disease appeared in infancy, evolved rapidly during adolescence and led to blindness. In both cases, the vasculopathy developed over several years and then stabilised; in contrast, the dystrophy, which was of the paucipigmentary type, continued to get worse. From these two cases, and others described in the literature, it appears that many causes can be involved in the association of the two syndromes. A genetic factor that has been demonstrated in several families was not present in these two patients; there appears to have been an immunological or inflammatory process, not yet identified, that became active at the time of the rapid evolution of the dystrophy.

Adolescent↗
PubMed1983

An internally-standardized assay for amphotericin B in tissues and plasma.

A high-performance liquid chromatographic (HPLC) method with p-nitrophenol as internal standard is described for the rapid analysis of amphotericin B recovered by methanolic extraction from tissues and plasma. Programmed, gradient elution of the ODS column was used with detection by tungsten light at 388 nm. Standard curves were derived based on the peak height ratios. The lowest reproducible limit of the assay was 0.04 micrograms/ml with plasma. The extraction and chromatographic procedures recovered 53-71% of the amphotericin B from each of these sources. The coefficient of variation of the recovery ratios was less than 18% from plasma over a range of concentrations of amphotericin B from 0.08 to 10.0 micrograms/ml. Recovery from tissues, studied over a narrower concentration range, showed a similar degree of precision. Variations in precolumns apparently resulting in selective binding of the amphotericin B were found to have a systematic but important influence on recovery efficiency. No substances were detected which interfered with the assay procedures as described. By incorporating an internal standard we have enhanced the reliability and flexibility of the HPLC assay for amphotericin B especially for assay of tissues.

Amphotericin B↗
PubMed1983

[Report of an atypical case of Goldenhar syndrome].

The authors report an atypical case of Goldenhar syndrome characterized by hemifacial and cranial hypoplasia associated with severe microtia and anophthalmia on the right side, antimongoloid palpebral fissures, epibulbar epidermoid, corneal anesthesia and preauricular tags on the left side. The bilateral presence of characteristic features of Goldenhar syndrome is rare and lends support to the possibility that the patient presents an intermediate form of developmental defect of the first branchial arch. The differential diagnosis is discussed.

Adolescent↗
PubMed1982

[Choroidal miliary tuberculosis: fluoroangiographic study (author's transl)].

The authors have followed the evolution of disseminated choroidal tuberculosis during a period of 16 months. At the beginning of the disease, fluorescein angiography showed an early 'screen effect' and later a 'focus effect'. During the later stage of the disease, the pigmented epithelium was seen to be involved as well, as demonstrated by (1) the presence of advanced pigmented chorioretinitis at the sites where the tubercles were observed at the beginning of the disease and (2) the presence of fluorescent areas early during fluorescein angiography.

Adolescent↗
PubMed1981

[Degenerative choroidal atrophy (author's transl)].

Based on of 10 personal observations, the authors discuss the modes of onset and the various clinical, functional and genetic aspects of primary degenerative choroidal atrophies. Central areolar atrophy may be the only lesion or is sometimes associated with other signs of a more extensive degeneration (fundus flavimaculatus, degeneration of the posterior pole). Among the diffuse forms a familial case is reported which can be interpreted as a sectorial hypoplasia, and a case similar to a choroideremia, but with recessive transmission.

Adult↗
PubMed1981

[Different manifestations of tapetoretinal degeneration in the same family (author's transl)].

A family with two siblings with six cases of tapetoretinal degeneration is reported. In the first case one individual present a degeneration of both scotopic and photopic visual systems, whereas another patient had macular degeneration of the Stargardt type. In the second, there was one case of photopic and stotopic degeneration, one case of fundus flavimaculatus, one case of Stargardt disease, and one case of retinitis pigmentosa inversa. The study of this family suggests on the one hand that Stargardt disease and fundus flavimaculatus are expressions of the same disease. On the other hand, the simultaneous presence of central and diffuse alterations of the fundus raises the question as to whether these various forms of hereditary degeneration may be included in a single class of disease.

Adolescent↗
PubMed1980

Chromosome 13 deletion syndrome: report of a new case and discussion of the different etiologic patterns of retinoblastoma.

A partial monosomy 13 by interstitial deletion was found in the complement of a patient with mental retardation and mild dysmorphic features. Due to the involvement of band q14 in the deletion, an ocular investigation was performed which showed the presence of a retinoblastoma in a preclinical stage. The different patterns of retinoblastoma inheritance are discussed and the importance of an accurate clinical investigation is stressed in all cases in whom chromosomal aberration is known to be associated with neoplasias.

Child, Preschool↗