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C Fersini

Publications and source records attributed to C Fersini.

61 records · Page 4Linked to original sources
PubMedDate not supplied

The maternal 24-h blood pressure (BP) profile as a predictor of fetal distress.

No mention is made of any aspect of BP bioperiodicity, among current clinical criteria for diagnosing pregnancy-related hypertension. The abnormal BP, based on a single unqualified measurement, is accepted and utilized as a clinical feature to identify pregnancy at risk. Systolic, diastolic and mean arterial blood pressure were measured every 15 min for 24 h in 5 women (2 non pregnant clinically healthy subjects, 1 clinically healthy subject in her third trimester of pregnancy, 1 presenting mild and 1 severe toxiemia, also in their third trimester of pregnancy) by an automated BP recording apparatus (Dynamap). All variables, analyzed by the single cosinor method, exhibited statistically significant circadian rhythms. A high amplitude could nullify the time-unqualified usual range. The change in circadian amplitude precedes an overt mesor hypertension and constitutes a tool for earlier detection of fetal distress.

Adult↗
PubMedDate not supplied

Circadian variations of sinus rate in subjects with sinus node dysfunction.

Circadian variations of sinus rate (SR) are well described in subjects with normal sinus node (SN). On the other hand there are no data in literature concerning the SR daily variations in patients with SN dysfunction. In order to clarify this problem we studied the SR circadian variation in healthy subjects (12) and in patients with intermittent bradycardia (11), persistent bradycardia (9) and intermittent 2:1 sino-atrial block (7). Sr was recorded utilizing ECG Holter monitoring. By histograms obtained every 2 h, maximum, modal, and minimum SR were evaluated. Time series were analyzed with a computer program for cosinor method. In the patients with normal SN, circadian periodicity in SR was confirmed with acrophase at 16(26) (Maximum SR), 16(38) (minimum SR) and 16(31) (SR mode), respectively. In patients with intermittent bradycardia a circadian rhythm was detected only in minimum SR (Acrophase: 16(51)) and in SR mode (acrophase: 16(13)). No statistically significant circadian variations of the 3 parameters of SR were observed in patients with both persistent bradycardia and sino-atrial block. These data suggest that: 1. the disappearance of the circadian periodicity is proportional to the severity of SN dysfunction; 2. the patients with intermittent bradycardia show a more normal behavior at low rates than at high ones; 3. the disappearance of circadian rhythm in patients with marked SN dysfunction can be related to the SN intrinsic involvement and/or autonomic nervous system dysfunction.

Adult↗
PubMedDate not supplied

Differences in some circadian patterns of cardiac arrhythmia, myocardial infarctions and other adverse vascular events.

BACKGROUND: Results from unpublished data on the incidence of adverse vascular events and from several published studies are reevaluated chronobiologically. METHODS AND RESULTS: Cosinor methods indicate 1. a circadian variation in the incidence of paroxysmal supraventricular tachycardia (PST), of broadly classified ventricular arrhythmia (VAr), and of atrial fibrillation (AF); 2. a statistically significant difference in the timing of the circadian rhythm of PST and VAr versus that of AF; and 3. a further difference in the timing of these rhythms from that in the incidence of myocardial infarctions (MI). Electrocardiographic records for spans longer than 24h show the extent of day-to-day variability in circadian characteristics of the given patient and indicate the presence of even lower-frequency components, notably along the scale of a week, that may underlie weekly and half-weekly patterns of morbidity and mortality. CONCLUSION: Beyond alterations in the about 1-Hz periodicity of the heart, predictable changes along the scales of the day and the week may constitute a clue to the etiopathology of a given condition and provide a basis for treatment timing. The assessment of unfavorable changes in the lower frequency components may provide a lead time long enough to prompt the institution of preventive, rather than curative, intervention.

Animals↗