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Biomedical subjects

C Feo

Publications and source records attributed to C Feo.

46 records · Page 3Linked to original sources
PubMedDate not supplied

Abnormal rheological response of erythrocytes caused by nitroimidazoles and hyperthermia.

The aim of the present study was to investigate the response of erythrocytes to hyperthermia in combined treatment with nitroimidazoles. The efficiency of nitroimidazoles and physical agents on the rheological response of erythrocytes was measured by the viscosimetric-diffractometric method in a continuous osmotic gradient with constant shear stress of 100 dyn/cm2. We found that three newly synthesized dinitro- or nitroimidazole derivatives caused oxidative damage of erythrocytes in aerobic conditions. Nitroimidazole structure-dependent decrease of erythrocyte deformability was accompanied by oxidation of haemoglobin and depletion of reduced glutathione, lipid peroxidation and alteration of membrane structure indicated by a decrease of the ANS fluorescence intensity and increased production of MDA. Heat treatment per se (from 42 to 45 degrees C) only slightly decreased the erythrocyte deformability, but markedly enhanced the structure-dependent effect of nitroimidazoles. Erythrocytes heated at 45 degrees C with dinitroimidazole derivative III lost their deformability without haemolysis. Dithiothreitol used in combination with nitroimidazoles during a heating period to 43.5 degrees C protected cell deformability entirely, indicating an important role for disulphide bond formation in membrane proteins submitted to oxidative stress and hyperthermia.

Dithiothreitol↗
PubMedDate not supplied

[Homogeneity of the erythrocyte volume distribution during chronic alcoholism macrocytosis (author's transl)].

The increase in volume of human erythrocytes during chronic alcoholic intoxication and its decrease after alcoholic deprivation was studied with a multichannel analyzer. When fractions of the population of red cells were separated by differential centrifugation the macrocytosis was found to be uniformly distributed. The presence of macrocytes was not related to changes of plasma osmolality or hyperhydration of red cells. A central origin was evoked, however, the role of the folic acid deficiency could not explain the macrocytosis, the mechanism of which remains to be elucidated.

Adult↗
PubMedDate not supplied

[Auto-immune hemolytic anemia revealed by erythroblastopenia linked to a parvovirus infection].

In a 12 year-old boy presenting with auto-immune hemolytic anemia of the IgG type, human parvovirus infection was responsible for acute erythroblastopenia. Aplastic crisis quickly and spontaneously recovered but auto-hemolysis was durable. Human parvovirus induced erythroblastopenia has only been reported in patients with constitutional hemolytic anemia. On the other hand, in this case, human parvovirus infection revealed the auto-immune hemolytic anemia.

Anemia, Hemolytic, Autoimmune↗
PubMedDate not supplied

[Video-laparoscopic splenectomy: experience in 3 cases].

BACKGROUND: In selected cases the spleen can be removed: METHODS: 2 women and 1 men with immune thrombocytopenic purpura, with hypersplenism without splenomegaly, underwent splenectomy by laparoscopic means. RESULTS: In 2 cases the splenectomy has been performed entirely by laparoscopic means. In 1 case the operation has been converted as we have not been able to control a venous bleeding from injured hilar spleen vessels. DISCUSSION: No particular technical problems arose in the 2 cases entirely conducted by laparoscopic means. Care must be taken manipulating the hilar vessels as the veins are fragile and their bleeding is difficult to be controlled in laparoscopy. The laparoscopic splenectomy seems to offer less postoperative pain, shorter hospitalization and improved cosmesis according to our previous experience with open splenectomy. CONCLUSIONS: The good result of the operations encourages the laparoscopic approach to splenectomy, in selected cases.

Adolescent↗
PubMedDate not supplied

[New directions in the surgical treatment of gastroesophageal reflux. Review of the literature].

The pathophysiology of gastroesophageal reflux disease (GERD) is often multifactorial, as abnormal function of the lower esophageal sphincter (LES) may be associated to abnormalities of the esophageal peristalsis, the esophageal clearance, and the gastric reservoir. The preoperative evaluation of patients with GERD must include esophageal function tests (esophageal manometry and ambulatory pH monitoring) and evaluation of the gastric emptying in addition to UGI series and endoscopy. The information provided by these tests is essential to identify the pathophysiology of the disease in the individual patient, and tailor the operative treatment accordingly. For patients with an incompetent LES but normal esophageal peristalsis, the Nissen fundoplication is the procedure of choice. When abnormal peristalsis and delayed clearance are identified by preoperative esophageal function tests, a partial fundoplication must be chosen in order to avoid postoperative dysphagia and gas bloat syndrome. Too many eponyms have been used to describe antireflux surgery (Nissen, Rossetti, Toupet, Lind, Hill, Guarner). It is time to go beyond these eponyms, and focus on the technical details which contribute to the stability of the wrap, as this is the main determinant of long term outcome.

Fundoplication↗