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Biomedical subjects

C Fenger

Publications and source records attributed to C Fenger.

At least 109 records · Page 6Linked to original sources
PubMed1981

Flow cytometric DNA analysis of anal canal epithelium and ano-rectal tumours.

Flow cytometric DNA analysis was performed on mucosal biopsies from the various epithelial types normally present in the anal canal, i.e. colo-rectal epithelium, ATZ-epithelium and squamous epithelium as well as from rectal and anal adenocarcinomas and squamous carcinomas of the anal canal. Normal colo-rectal mucosa show homogeneous cell populations with diploid DNA values, while adenocarcinomas contain diploid as well as aneuploid cell populations, regardless of location in the rectum or in the anal canal. The ATZ-epithelium shows a dominating normoploid population with a small "hyperdiploid" peak. Polyploid nuclei were not found. The findings indicate that the ATZ-epithelium is related to metaplastic epithelium rather than to urothelium. The variants of squamous carcinoma in this study were rather poorly differentiated, but the FCM-analysis showed a near diploid population with a high proliferative activity. The number of cases, however, is too small to be conclusive.

Anal Canal↗
PubMed1981

Dysplastic changes in the anal canal epithelium in minor surgical specimens.

A ten-year consecutive material of 306 minor surgical specimens from the anal canal showed squamous dysplasia in 2.3 per cent. None of the patients developed carcinoma during an average observation time of 27 months. The average age was 64 years for dysplasia and 67 years for a corresponding series of 12 cases of anal canal carcinoma. It is concluded that all material from the anal canal should be investigated histologically.

Adenoma↗
PubMed1979

Histochemical characteristics of mucins in the small intestine. A comparative study of normal mucosa, benign epithelial tumours and carcinoma.

The histochemical properties of the mucins in seven benign epithelial tumours and 15 carcinomas distributed along the duodenum, jejunum and ileum were investigated and compared with normal controls. This study reveals that (a) goblet cells in normal small intestine contain neutral and sialomucins but no sulphated material; (b) the proportion of the different types of mucins in the goblet cells vary along the crypts and villi with an increasing amount of sialomucins towards the villus top; (c) mucin composition also changes from duodenum to ileum particularly in the proportions of sialic acid types and in the presence of traces of sulphomucins in the ileal mucosa close to the ileo-caecal valve, suggesting a gradual transition through the small intestine to the colon; (d) benign tumours show the same mucin pattern as normal mucosa; (e) the adjacent to carcinoma shows increasing amounts of sialomucins and sulphomucins; (f) carcinomas present a variety of mucin patterns, and thus the study of mucins seems to be of no value in differentiating tumours of the small intestine from those elsewhere in the gastrointestinal tract. A working hypothesis based on the Unitary Theory of the origin of the intestinal epithelial cells is proposed to explain the variations in glycoprotein synthesis with cell differentiation and carcinogenes.

Adult↗
PubMed1979

The anal transitional zone. Location and extent.

The location and extent of the anal transitional zone (ATZ) were investigated in the age group typical for anal canal carcinomas. The methods used were macroscopic determination after whole-mount staining with Alcian-dyes as well as conventional histological technique. The results show that the epithelial variants may be found over a larger area than previously reported, namely from 6 mm below to 20 mm above the dentate line. Variations in location and extent of the ATZ are described, as well as the frequent finding of mature squamous epithelium high in the anal canal. The significance of the findings in relation to the special types of anal canal carcinomas is discussed, and on the basis of the macroscopic definition of the canal, as well as the histological observations in this study, it is proposed that anal canal carcinomas should be defined as tumours partly or totally located within a distance of 2 cm above the dentate line.

Adenocarcinoma↗
PubMed1978

Gastric ulcer in old age.

One hundred and eleven (16%) of 701 patients with gastric ulcers, admitted to Kommunehospitalet, Copenhagen, from 1955 to 1964, were 70 years of age of older. Of those elderly patients, 43 were treated surgically, 68 non-surgically. The incidences of hemorrhage and extragastric diseases were significantly greater in older patients, whereas the incidence of pain, site of pain, ulcer size, and location, incidence of combined ulcers and gastric retention did not differ from those observed in younger patients. The duration of symptoms was shorter in the aged, though the difference was not significant. Prognosis was less favourable in the aged, largely due to a higher incidence of hemorrhage (47%) and of accessory diseases (47%). The mortality in elderly patients suffering from hemorrhage and accessory diseases was 64% during hospitalization, but only 4% in patients without accessory diseases. Follow-up and autopsy studies of discharged patients revealed that ulcers healed in only half of the non-surgical patients and that surgery was ultimately necessary in 50% of these. It was concluded that the factors which prescribed surgical treatment in elderly patients with gastric ulcers did not differ considerably from those in younger patients. The risk was greater, but this was also true in non-surgical treatment. Close cooperation between surgeon and physician was essential, both pre- and postoperatively, since accessory diseases were very significant for the outcome.

Age Factors↗
PubMed1978

The anal transitional zone. A method for macroscopic demonstration.

The anal canal extends from the upper to the lower border of the internal sphincter. The canal can histologically be divided into three zones according to the epithelial lining, being of colo-rectal type in the upper part and squamous in the lower part, while the middle part, where the epithelium varies, is called the anal transitional zone (ATZ). This zone can be demonstrated macroscopically using whole mount staining with Alcian dyes, which reveal it as light green or blue, contrasting to the dark stained rectal type mucosa above and the unstained squamous epithelium below. Comparison with histological section shows that this zone corresponds with reasonable accuracy to the anal transitional zone.

Anal Canal↗
PubMed1977

Pathology of the anal glands with special reference to their mucin histochemistry.

The anal gland pathology comprises cystic anal glands (so-called anal gland cyst hamartomas), anal gland carcinomas, and anal fistulas with or without carcinoma. The differential diagnosis of these conditions from other cysts and carcinomas of the anal region can be difficult. The authors have therefore compared conventional history with mucin histochemistry in normal and pathological anal glands. In contrast to normal rectal mucosa the mucus of anal glands was characterized by strong PAS-reactivity that was completely abolished after periodate borohydride saponification indicating scarcity of absence of O-acylated sialic acids in the anal gland mucus. A pattern similar to this was found in one of two tumours classified histologically as anal gland carcinomas, in four of eight colloid carcinomas arising in preexisting fistulas, and in two cases of mucoepidermoid carcinoma of the anal region. The results indicate that the method in some cases may be of value in differentiating between carcinomas arising in anal gland epithelium and in rectal mucosa. The cystic anal glands showed decreased secretion but no qualitative histochemical differences from anal glands. On the basis of the patients' histories it is suggested that the so-called anal gland cyst hamartoma at least in some cases could be an inclusion cyst of anal glands on the inflammatory basis.

Adult↗
PubMed1975

Causes of death in patients with gastric ulcers.

Of 701 patients with gastric ulcers admitted to hospital within the period 1955-64, 180 died within a five-year period calculated from the time of admission. Causes of death were established at autopsy in 66%, and otherwise were derived from death certificates. The mortality in our series is grouped after the sex and age of the patients, and the causes of death are compared with the corresponding sex and age groups of the Copenhagen population. Mortality was significantly higher than expected in both men and women, particularly high in the first year after actual admission, but falling thereafter to about the same level as the expected mortality. Gastric ulcer itself was the most usual cause of death, but other disease was also significant. Thus mortality from suicide was significantly higher than expected in women. That there is a relationship between operation and suicide seems unlikely--all concerned had psychiatric histories. In men, pulmonary disease involved a significantly higher mortality than expected, and some connection between ulcer disease and pulmonary disease seems possible. If patients dying from cancer of the stomach within a two-year period are excluded, mortality from this disease was not significantly higher than expected. Thus the study gives no support to that theory that benign gastric ulcers are prone to malignant degeneration.

Adolescent↗