[Non-steroidal anti-inflammatory agents and kidney diseases].
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Anti-Inflammatory Agents, Non-Steroidal↗
Biomedical subjects
C Faucher
Publications and source records attributed to C Faucher.
Severe chloroquine-resistant falciparum malaria in Gabon with decreased sensitivity to quinine.
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Adult↗
[Neuropsychological repercussions of chronic alcoholism.].
Although there is no evidence of general intellectual deterioration in chronic alcoholics, several specific deficits have been identified in them during neuropsychological tests used to evaluate their cognitive, mnemonic, visual-motor and spatial capacities. The neurological interpre-ation of this data allows one to suppose that diffuse cerebral damage exists, involving in particular the frontal lobes and their functional connections with the limbic and diencephalic structure. Although a substantial recuperation is effected during the 2 or 3 weeks following the termination of alcohol consumption, the restoration of the functions remains generally incomplete; thus the necessity for treatment programs adapted to the needs and capacities of this population and the elaboration of techniques aimed at the maximum recuperation of these deficits.
English Abstract↗
Psychosocial aspects of haematopoietic stem cell donation for allogeneic transplantation: how family donors cope with this experience.
Peripheral blood stem cell (PBSC) allogeneic transplantation is an innovative medical procedure which has many advantages in comparison with bone marrow (BM) transplantation, but it involves administering haematopoietic growth factors (HGFs) to donors, the long-term physiological effects of which have not yet been established. The main aim of the present study was to analyse how family PBSC donors cope when confronted with this particular risk context. In addition to data collected on the personal and social aspects of the donors' experience, questionnaires were used to measure their quality of life (pain and anxiety) before, during and after donation, and they were subsequently interviewed in depth by a psychologist. Twenty-two donors participated in this study. They did not all react to the experience of blood cell donation in the same way, in terms of their own personal feelings, attitudes towards the donation, their relationships with the other members of the family, and their awareness of the risk involved.
Adaptation, Psychological↗
High-dose chemotherapy with hematopoietic stem cell support in patients with advanced epithelial ovarian cancer: analysis of 67 patients treated in a single institution.
BACKGROUND: Advanced ovarian carcinoma is a chemosensitive tumor, but its prognosis is poor with 20 to 30% 5-year survival using conventional therapy. Increasing doses of chemotherapy might improve the prognosis because of the dose-effect. MATERIALS AND METHODS: Between 1980 and 1994 at Institut Paoli-Calmettes, 67 patients with advanced ovarian cancer were treated with different alkylating agents-based regimens of high dose chemotherapy (HDC) and hematopoietic stem cell support (HSCS). The population was divided in 2 groups: a salvage group (n = 30) including initial conventional chemotherapy-refractory patients, and a consolidation group (n = 37) including patients whose disease was sensitive to classical first-line chemotherapy after debulking surgery. RESULTS: Toxicity was essentially hematological (severe aplasia) and digestive (mucositis). Four toxic deaths occurred related to infection during immunosuppression. In the salvage group, 9 out of 22 evaluable patients responded (41%), but the duration of responses was short (median range of 6 months) and the 2-year overall survival rate was 13%. In the consolidation group, 17 patients are still alive, 12 with progression with a median follow-up of 63 months. The 5-year disease-free survival rate was 32% while the 5-year overall survival rate was 46%. CONCLUSIONS: Toxicity of HDC with HSCS is acceptable for poor-prognosis patients. In the long term, this therapy is not beneficial for chemotherapy refractory patients, despite objective response rates better than the conventional treatment, confirming the dose-effect for alkylating agents in ovarian cancer. On the other hand, the results seem better than classical therapy in case of chemosensitive disease and should be confirmed prospectively in a larger cohort of patients.
Antineoplastic Agents, Alkylating↗