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Biomedical subjects

C Farsang

Publications and source records attributed to C Farsang.

84 records · Page 5Linked to original sources
PubMed1978

Effect of external compression on the postocclusion hyperaemic response of the coronary arteries in the isolated fibrillating dog heart.

The effect of external compression on the postocclusion hyperaemic responses (occlusion time 15, 30, 60 sec) has been studied on the fibrillating canine heart. The heart was placed in a closed organ box containing physiological saline solution, and the coronaries were perfused with blood from a donor dog using a constant volume perfusion technique at 150 mmHg perfusion pressure. The pressure in the organ box varied between 0--50 mmHg. As the compression pressure increased in the organ box, coronary blood flow, basal conductance as well as the parameters of the postocclusion hyperaemic reaction (peak conductance, reactivity, mean transit time of hyperaemia, postocclusive conductance area, and repaymen) decreased. The factors (tissue diffusion, tissue pressure, transmural pressure) at the capillary level can influence the regulation of the postocclusion vasodilatation and the results cannot be explained by metabolic and/or myogenic processes alone.

Animals↗
PubMed1977

Effect of norepinephrine on myocardial reactive hyperaemia in the isolated fibrillating dog heart.

The effect of intracoronary norepinephrine (NE) infusion in a dose of 2 microgram/min on postocclusion hyperaemic reactions following occlusions of 15 sec, 30 sec, 60 sec, and 120 sec was studied on isolated fibrillating, blood-perfused canine hearts. Basal perfusion pressure was kept at the level of 150 mm Hg; perfusion was done with constant pressure or constant volume. During administration of NE, basal flow and basal coronary conductance increased with both perfusion techniques. In the postocclusion period during administration of NE, peak conductance, maximum conductance, reactivity, mean transit time of reactive hyperaemia, postocclusive conductance area and repayment decreased. The differences found in postocclusion reactions in the control state originated from the different perfusion techniques disappeared when NE was infused. The phenomena may be explained by the stimulation of alpha and beta receptors as well as of myocardial metabolism by NE. The results support earlier views which ascribe a decisive role to vasoactive metabolites in the postocclusion reaction after prolonged occlusions. The decrease in reactive hyperaemia by NE may contribute to the development of angina pectoris.

Angina Pectoris↗
PubMed1977

Effect of vasopressin on myocardial reactive hyperaemia in the isolated fibrillating dog heart.

The effect of 0.15 IU/min vasopressin (VA) administered intracoronarily on postocclusion reactions following 15 sec, 30 sec, 60 sec, and 120 sec occlusions of the left coronaries of the isolated fibrillating dog heart were studied at constant pressure or constant volume perfusion with arterial blood of another dog. Basal perfusion pressure was kept at the level of 150 mmHg. Preocclusion state and postocclusion reactions were characterized by changes in coronary conductance. Peak conductance, maximum conductance, reactivity, time to peak conductance, mean transit time and repayment were computed for characterizing reactive hyperaemia. In the control state the post-occlusive conductance--time curve was higher, but shorter in duration with constant pressure perfusion than with constant volume perfusion. Upon the administration of VA, basal conductance decreased considerably while with constant pressure perfusion the hyperaemic reactions underwent hardly any change. In contrast, using constant volume perfusion, the duration of reactive hyperaemia was shortened by VA. Consequently, the differences in mean transit time observed in the controls resulted from the unequal perfusion techniques disappeared on the application of VA. On both constant pressure and constant volume perfusion, maximum conductance decreased as a result of the decrease in basal conductance, therefore the reactivity of the coronary vessels increased markedly. It is concluded that myogenic vasorelaxation may contribute to reactive hyperaemic responses not only on brief, but also on prolonged occlusion. The basal vascular tone is of importance in the coronary adaptation to ischaemia.

Animals↗
PubMed1975

Circulation in rats with Guérin carcinoma.

After implantation of Guérin carcinoma in rats, cardiac output (by Evans-blue dilution), distribution of the organ fractions of cardiac output (by Sapirsteins's isotope indicator fractionation technique), nutritive blood flow and circulatory resistance of the organs (including the tumor) were studied. The following parameters were altered proportionately to the weight of the tumor (0.39-84.0 g): a) weight of gut and carcass diminished; b) cardiac index increased, blood pressure and total peripheral resistance decreased; c) tumor fraction of cardiac output was augmented; d) blood flow of the organs increased and their circulatory resistance decreased. Hematocrit decreased from 47.2 to 31.0% 20 days after tumor implantation. In rats with tumor the changes of blood flow may be conditioned by both anemia and the decrease in organ weight.

Animals↗
PubMedDate not supplied

An open-label study investigating the efficacy and safety of 12-96 weeks of telmisartan treatment in patients with hypertension.

This open-label, multicentre, multinational trial evaluated the efficacy and safety of telmisartan used alone or as add-on therapy in 2121 adults with mild-to-moderate essential hypertension. Patients received telmisartan 40-80 mg once daily for 12 weeks and could participate in the study for up to 96 weeks, or until a marketed supply of telmisartan became available. Mean change from baseline in mean seated trough diastolic blood pressure (DBP) after 12 weeks' treatment, the primary endpoint, was -11.8 mmHg in the intent-to-treat population. The corresponding mean change in mean seated trough systolic blood pressure (SBP) was -20.2 mmHg. Both changes were statistically significant. Mean DBP and SBP reductions were apparent from week 4 and maintained throughout the treatment period. Telmisartan was well tolerated; the most common adverse events were headache (6%) and dizziness (3%), and 10% of adverse events were considered drug-related. In conclusion, telmisartan is an effective and well-tolerated drug when used as monotherapy or add-on treatment in this broad population of patients.

Adult↗