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Biomedical subjects

C Farina

Publications and source records attributed to C Farina.

155 records · Page 9Linked to original sources
PubMedDate not supplied

Concomitant subclavian and carotid artery disease: the need for a combined surgical correction.

To determine the importance of carotid artery disease in patients undergoing revascularization of the proximal subclavian artery for a subclavian steal syndrome, an 18-year experience of 55 patients was reviewed. Concomitant carotid artery disease (> 50% stenosis) was present in 35 patients (Group I: 63.6%). Twenty patients (Group II: 36.4%) had no evidence of hemodynamically significant carotid disease. Twenty-five patients in Group I (Group IA: 71.4%) were treated by endarterectomy (CEA) for all their carotid lesions while one or both carotid lesions were left untreated in 10 patients (Group IB: 28.6%). The actuarial 5-year freedom rate from neurological events was 87.2% in Group IA, 34.9% in Group IB (p < 0.001) and 100% in Group II (Group IB vs. II, p < 0.001; Group IA vs. Group II, p = ns). All untreated carotid lesions had a deleterious effect on the early and late functional results after surgical reconstruction of the subclavian artery. We conclude that the combined correction of subclavian and carotid lesions should be recommended in every case.

Actuarial Analysis↗
PubMedDate not supplied

Synthesis and nootropic activity of 2-oxo-1-pyrrolidinesulfonic acid derivatives.

The synthesis of a series of 2-oxo-1-pyrrolidinesulfonic acid derivatives, as potential nootropic agents, is reported. Such compounds were designed to have chemical and physico-chemical properties intermediate between 2-oxo-1-pyrrolidineacetamides (e.g. oxiracetam) and 1-acyl-2-pyrrolidinones (e.g. aniracetam). The ability of these compounds to counteract the ECS-induced amnesia in mice was assessed in a one trial, step through, passive avoidance paradigm. Whilst oxiracetam and aniracetam confirmed their antiamnestic action, none of the title compounds showed a statistically significant activity.

Animals↗
PubMedDate not supplied

Late upper limb acute ischemia in a patient with an occluded axillo-femoral bypass graft.

A case of severe upper limb ischemia that occurred three months after the occlusion of an axillo-femoral bypass graft (AXB) is described, the third case to be reported in the literature. Although the pathogenesis of this complication is far from clear, the possible role of a short graft in determining traction and finally an angulation of the donor artery is hypothesized. The exact correspondence existing between the length of the AXB and the body size could be altered during the postoperative period by an excessive increase in body weight. The graft could become relatively short for the new conformation and angulation of the axillary artery could be provocated. On the basis of our experience and in reviewing the literature, we believe that an occluded AXB still represents a risk for the donor artery that must be carefully evaluated during accurate follow-up of the patient.

Aged↗
PubMedDate not supplied

Possible pathogenic role for Sporothrix cyanescens isolated from a lung lesion in a heart transplant patient.

Sporothrix cyanescens is a fungus rarely isolated from human specimens. Its pathogenic role has never been demonstrated but has been postulated on the basis of its occurrence in normally sterile body sites, its isolation from debilitated individuals and its thermotolerance. A first case of nodular pulmonary lesions developing in an immunosuppressed, heart transplant patient is reported. Sporothrix cyanescens was isolated from a fine needle lung biopsy. The patient failed to respond to itraconazole therapy, whereas he was successfully treated with amphotericin B.

Amphotericin B↗