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Biomedical subjects

C Faravelli

Publications and source records attributed to C Faravelli.

58 records · Page 4Linked to original sources
PubMedDate not supplied

[Alprazolam versus lorazepam in the treatment of anxiety: controlled clinical study].

58 patients suffering from anxiety neurosis were divided into two groups, matched for age, sex, marital status and symptomatology. In a double-blind trial of 4 weeks' duration one group (28 patients) received alprazolam 0.75-3 mg/day and the other (30 patients) received lorazepam 3-12 mg/day. Both groups showed a steady and significant reduction in anxiety levels as measured by Hamilton Anxiety Rating Scale and Clinical Global Impression scores at 0, 1, 2 and 4 weeks. However, there was no significant difference in measured anxiety levels between the two groups at any stage. Fewer side effects were reported in the alprazolam treatment group, with the mental confusion symptom occurring significantly less often.

Adult↗
PubMedDate not supplied

[Lithium in the prophylaxis of recurrent affective disorders. Effectiveness of low plasma levels and predictors to clinical response (author's transl)].

Thirty-eight patients suffering from recurrent affective disorder were treated at the Lithium Clinic of the Department of Clinical Psychiatry, University of Florence, with lithium carbonate for a period of 3-8 years; twenty-four (76%) had good response. The latter was defined as a decrease of at least 50% of recurrences during the period of treatment when compared with those of the period preceding treatment. This improvement was obtained in spite of the fact that plasmatic lithium was maintained within 0.40-0.80 mEq/l, a range lower than recommended. However, patients who sometimes let this value fall below 0.40 had significantly increased relapses. No marked toxic effect was recorded. Some factors (bipolar illness, typical symptom pattern and, probably, family history of affective disorder) were associated with a favourable outcome. However, the absence of these did not predict a poor response in more than 40% of the cases. The authors therefore conclude that it is worthwhile to start a lithium treatment whenever a diagnosis of recurrent affective disorder is met.

Affective Disorders, Psychotic↗
PubMedDate not supplied

Cross-national epidemiology of major depression and bipolar disorder.

OBJECTIVE: To estimate the rates and patterns of major depression and bipolar disorder based on cross-national epidemiologic surveys. DESIGN AND SETTING: Population-based epidemiologic studies using similar methods from 10 countries: the United States, Canada, Puerto Rico, France, West Germany, Italy, Lebanon, Taiwan, Korea, and New Zealand. PARTICIPANTS: Approximately 38000 community subjects. OUTCOME MEASURES: Rates, demographics, and age at onset of major depression and bipolar disorder. Symptom profiles, comorbidity, and marital status with major depression. RESULTS: The lifetime rates for major depression vary widely across countries, ranging from 1.5 cases per 100 adults in the sample in Taiwan to 19.0 cases per 100 adults in Beirut. The annual rates ranged from 0.8 cases per 100 adults in Taiwan to 5.8 cases per 100 adults in New Zealand. The mean age at onset shows less variation (range, 24.8-34.8 years). In every country, the rates of major depression were higher for women than men. By contrast, the lifetime rates of bipolar disorder are more consistent across countries (0.3/100 in Taiwan to 1.5/100 in New Zealand); the sex ratios are nearly equal; and the age at first onset is earlier (average, 6 years) than the onset of major depression. Insomnia and loss of energy occurred in most persons with major depression at each site. Persons with major depression were also at increased risk for comorbidity with substance abuse and anxiety disorders at all sites. Persons who were separated or divorced had significantly higher rates of major depression than married persons in most of the countries, and the risk was somewhat greater for divorced or separated men than women in most countries. CONCLUSIONS: There are striking similarities across countries in patterns of major depression and of bipolar disorder. The differences in rates for major depression across countries suggest that cultural differences or different risk factors affect the expression of the disorder.

Adolescent↗