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Biomedical subjects

C Fabris

Publications and source records attributed to C Fabris.

At least 199 records · Page 11Linked to original sources
PubMed1984

The cord blood oxygen affinity from normal human newborns: 1) A methodological approach.

A correct analysis of O2 affinity in neonatal whole blood puts some important, still unsolved problems of methodology, mainly based upon the fact that this kind of blood is a mixture of at least two major hemoglobins, i.e. 2/3 Hb-F and 1/3 Hb-A, having different affinities. Whereas adult blood mainly contains Hb-A. Within such a perspective, the Authors have checked if the empirical Davenport's nomogram, correcting the pO2s of adult blood to the same standard pH of 7.4, can also be used for neonatal blood. The answer is affirmative, and in addition the nomogram can also be replaced, with some advantage, by an only mathematical correction of the measured pO2s, in which pH differences from 7.4 (either positive or negative) are converted in proportional differences of pO2 and either added or subtracted to the values of these latter. Hb-CO level is undoubtedly higher in newborns than in non-smoker adults, but no factor for T50 calculation of neonatal blood has been till now identified. The Authors have determined a factor of -0.36, which can be obtained from the homologous (experimental) "adult" factor of -0.27, by multiplying this latter for 1.35.

Adult↗
PubMed1984

The three polymorphic chains of human Hb-F studied in normal Italian newborns.

Both the known polymorphisms of human Hb-F have been investigated here. Two similar groups of full-term newborns have been considered: pure F-globin has been studied by suitable fingerprinting techniques in the first group, while isoelectrofocusing techniques have been employed in the second. The results clearly indicate that G/A gamma polymorphism can be correctly determined with both the procedures, while the T/I gamma polymorphism cannot, because IEF is not sensitive enough towards low quantities of A gamma T chains. Moreover, in the first group of newborns, the A gamma T gene frequency (P) is 0.23, while the total G/A gamma ratio of both groups is about 7/3, the two data being in full agreement with those of the literature. Furthermore, additional reports show that the main functional parameters of the whole neonatal blood are not significantly different either in the presence or in the absence of A gamma T chains.

Alleles↗
PubMed1984

The oxygen affinity of normal human whole blood measured by double tonometry. I. P50 and n factor.

The Authors refer that the oxygen affinity, determined by double tonometry, in normal adult whole blood, is mainly expressed by a P50 of 26.13 +/- 4.31% and by an n factor of 2.63 +/- 6.63%. These results are in good agreement with those reported in the literature, but here are some doubts that pO2 and SO2 alone, i.e. the data drawn from all the tonometric procedures, can give a full idea of the affinity. In fact, this one is a complicate process, modulated by a number of allosteric effectors. Most of them, like pH, temperature and pCO2 can be always kept at a fixed standard level, whereas DPG, the main one, cannot.

Adolescent↗
PubMed1984

The oxygen affinity of normal human whole blood measured by double tonometry. II. pH-depending Bohr effect and DPG.

Following another preliminary work on the whole blood oxygen affinity, the Authors have found in this occasion normal values of the pH-depending Bohr effect in healthy subjects of both sexes and different age. Furthermore, the Hb decreasing causes in these cases also a P50 increasing which is mediated by raised DPG levels. However, while in the anemias this effect is constant, many exceptions have been found in physiological conditions. Since these ones have been mainly detected at the maximal DPG levels, the phosphate could modify the affinity not only as allosteric effector, but also by acting on pH and related equilibria as non diffusible free anion. These interferences are difficult to be calculated and often could disturb notably a correct use of the common mathematical model which describes the oxygenation.

Adolescent↗
PubMed1984

Study of retinol-binding protein in pancreatic cancer.

Serum RBP, prealbumin, and zinc were evaluated in normal subjects and patients with pancreatic cancer and chronic pancreatitis. A significant decrease of RPB was found in pancreatic cancer patients compared with controls. A concomitant reduction of prealbumin and zinc was also observed. Multiple regression analysis suggested that the modification of RBP serum levels might be accounted for mainly by diminished prealbumin levels, while the direct role of zinc is negligible.

Adult↗
PubMed1984

Combined evaluation of serum ribonuclease and ferritin: any advantages in pancreatic cancer diagnosis?

In 116 subjects, serum ribonuclease (RNase) and ferritin were determined in order to evaluate whether their combined evaluation might improve the diagnostic accuracy of each test. Significantly higher levels were found in pancreatic cancer patients both for RNase and ferritin than in control subjects and chronic pancreatitis. Sensitivity and specificity in diagnosing pancreatic cancer were 86% and 46%, respectively for RNase; 76% and 65% for ferritin. One of the two tests was pathological in 100% of pancreatic cancer, with a specificity of 29.9%; both were pathological in 62.1%, with a specificity of 82.1%. The results emphasize the limits of the combined assessment of pancreatic cancer markers.

Adult↗