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Biomedical subjects

C F Winkler

Publications and source records attributed to C F Winkler.

26 records · Page 2Linked to original sources
PubMed1979

Low-dose versus high-dose insulin therapy for diabetic ketoacidosis.

The effects of low-dose continuous insulin therapy were compared to those of high-dose subcutaneous and intravenous insulin therapy in six episodes of diabetic ketoacidosis. Time for correction of acidosis, ketosis, and hyperglycemia were similar for both regimens. The high-dose method required more exogenous glucose and supplemental potassium to avoid hypoglycemia and/or hypokalemia during treatment. Levels of cortisol, human growth hormone, and glucagon, initially elevated in most patients, showed a progressive decline with both modes of therapy. Plasma insulin remained remarkably stable during both treatment regimens, but remained within the physiologic range only in patients receiving low-dose therapy. Our study suggest that either modality is effective in the treatment of diabetic ketoacidosis.

Adult↗
PubMedDate not supplied

Immunocytochemical diagnosis of oat-cell carcinoma in pleural effusion.

Immunocytochemical studies were performed in order to accurately recognize the origin of tumor cells in a pleural effusion from a patient with a mediastinal mass. The immunoalkaline phosphatase technique was employed to examine several cell-specific surface antigens via their specific monoclonal antibodies. The tumor cells in this case did not have any demonstrable antigens of the human blood cells but did have abundance of an antigen specific for the tumor cells of oat-cell carcinoma. This diagnosis obtained by the immunochemical studies was confirmed by both cytologic and clinical findings. Immunocytochemical studies may become a mainstay for specific cytodiagnosis in the future.

Acid Phosphatase↗