Verrucous carcinoma of the vulva.
A patient with verrucous carcinoma of the vulva is presented. A radical vulvectomy and superficial inguinal lymphadenectomy was done. The short-term result was satisfactory.
Aged↗
Biomedical subjects
C F Slabber
Publications and source records attributed to C F Slabber.
The effect of lumbar epidural analgesia on the fetal heart.
Fetal heart rate was monitored by continuous cardiotocography in 67 patients who were subjected to standard epidural block. In 43% of cases a deterioration in the fetal heart rate pattern was observed. The abnormal heart rate usually responded to conservative treatment. In 3 cases caesarean section was necessary. The deterioration of the fetal heart rate was usually associated with maternal hypotension.
Anesthesia, Epidural↗
The prognostic value of serum human placental lactogen determinations in early pregnancy.
Serial serum human placental lactogen (S-HPL) determinations were done in early pregnancy on 85 high-risk cases. Normal S-HPL values with a normal ultrasonogram had a 94.8 per cent successful outcome of pregnancy. Low S-HPL values were often accompanied by an abnormal or equivocal ultrasonogram (29.6 per cent). The fetal loss in patients with low S-HPL values and a normal ultrasonogram was 36.8 per cent.
Abortion, Threatened↗
Afrikaans as a medium of communication in medicine.
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Books↗
Treatment of threatened and habitual abortion with human chorionic gonadotrophin. The role of serum human placental lactogen determination.
Treatment of habitual and threatened abortion with human chorionic gonadotrophin (HCG) is discussed. Two problems are encountered: the selection of patients for treatment; and the correct dosage of HCG. Determination of human placental lactogen (HPL) in the serum was used to select patients for treatment. The dosage of HCG was varied according to the response of the patient and as indicated by the levels of HPL in her serum.
Abortion, Habitual↗
Diagnosis and treatment of advanced extra-uterine pregnancy.
Eighteen cases of advanced extra-uterine pregnancy are reported. The difficulty of diagnosis is discussed; the only symptoms of any help were amenorrhoea, lower abdominal pain, postmaturity and failed induction of labour. The physical findings were variable and none were absolutely reliable. In 17 cases the fetus was dead on admission and early laparotomy was performed, and in 17 patients it was possible to remove the placenta completely.
Adult↗
The prevention of endotoxin-induced glomerular fibrin deposition by pyrimido-pyrimidine compounds.
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Animals↗
Absorbed dose calculations for 113mIn placental scanning.
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Animals↗
Spermagglutinating antibodies: a comparison of three different techniques.
In 136 patients tests were performed to demonstrate circulating spermagglutinating antibodies. In patients with "unexplained" infertility (15 cases) antibodies were demonstrated in six (40%) whereas in patients where another cause for infertility was present (101 cases) additional positive spermagglutinating antibodies were demonstrated in 15 (15%). In the 21 cases with spermagglutinating antibodies the Friberg test was positive in 17 cases (81%), the Kibrick test in 14 cases (67%) and the Franklin-Dukes test in four cases (19%).
Adult↗
A possible relationship between prolactin and spermatogenesis in humans.
In order to investigate the effect of prolactin on spermatogenesis, we studied 205 consecutive male patients in whom 121 were normozoospermic (counts greater than 20 x 10(6)/ml), 62 were oligozoospermic (counts less than 20 x 10(6)/ml), and 22 were azoospermic. We compared prolactin with semen analysis. There was an increased incidence of high prolactin levels in the oligozoospermic and azoospermic group of patients. We noted an increase in the number of morphologically normal spermatozoa within the hyperprolactinaemic groups of patients. This may suggest that prolactin plays a regulatory role in spermatogenesis.
Adult↗
A comparison of endocrine function and semen analysis in fertile and subfertile men.
We studied 122 normozoospermic, 62 oligozoospermic and 22 azoospermic patients and compared serum testosterone, LH and FSH with semen analysis. Testosterone was similar in all three groups studied. FSH rose significantly in the oligozoospermic and azoospermic groups (p less than 0.01). LH was similar in the normozoospermic and oligozoospermic groups but rose significantly in the azoospermic group (p less than 0,01). The rise in FSH is in accordance with the theory of inhibin release during the maturation states of spermatogenesis. The rise in LH might indicate a separate feedback mechanism mediated by the early stages of spermatogenesis and not by testosterone alone.
Adult↗
Reproductive immunology: 1. The effect of different protein concentrations of seminal plasma on in vitro lymphocyte cultures.
Certain components of the male genital tract are capable of inhibiting the transformation rates of in vitro lymphocyte cultures. In the present study the effect of human seminal plasma was investigated for it inhibitory properties when used in varying protein concentrations together with different dilutions of Phytohaemagglutin-M (PHA-M). It is concluded that whole human seminal plasma is suitable in inhibition studies provided an optimal protein concentration is used.
Humans↗
Corticosteroid therapy in case of immunologic infertility--a preliminary report.
Six couples with immunologic infertility were treated with corticosteroids. In five patients prednisone 5 mg three times daily were used and in one patient methylprednisolone 96 mg daily for seven days. The duration of therapy varied from two to eleven months before any positive results occurred. In five patients the serum antibody titre declined significantly and three pregnancies resulted. In the two cases where the serum antibody titre declined, but the SCMC test did not improve, pregnancy did not result. The follow-up SCMC test after completion of therapy may have more prognostic value than the serum sperm antibody estimations.
Antibodies↗
Reproductive immunology: 3. the effect of seminal plasma from oligozoospermic men on in vitro lymphocyte cultures.
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Humans↗
Reproductive immunology: 4. The effect of seminal plasma from immunologic infertile men on in vitro lymphocyte cultures.
The seminal plasma of 31 patients were examined for the presence of sperm antibodies and for inhibitory properties on the transformation rates of donor lymphocytes cultured in vitro. Twenty five (80%) of the men revealed apart from fertile semen, no sperm antibody activities while six (20%) patients showed high spermagglutinating antibody titres in their seminal plasma and blood serum. Following the routine semen analyses and sperm antibody estimations the seminal plasma were used in lymphocyte transformation studies in order to examine their inhibitory effect. The influence of the seminal plasmas on the lymphocytes were expressed as a percentage inhibition. The percentage inhibition of the normozoospermic men differed significantly from the immunologic infertile man (p less than 0,05). We concluded from the study that the inhibitory potential of the seminal plasma from immunologic infertile male with a normal sperm count are elevated compared with that of normozoospermic men without sperm antibodies. It also appears as if the sperm antibodies in the seminal fluid are able to bind with the inhibitory factor thus causing an enhanced inhibition effect on the lymphocytes.
Antibodies↗
The SCMC test: a screening test for spermatozoal antibodies.
The sperm cervical mucus contact test (SCMC-test) were performed on 62 couples on account of their post coital test results. Fifteen of the 17 couples (88%) who repeatedly demonstrated unexpected poor post coital tests, revealed a positive SCMC-test. In 10 cases the SCMC test results were confirmed by the tray-agglutination and mixed antiglobulin reaction. The SCMC-test is considered to be a reliable screening test for the detection of spermantibodies amongst infertile couples.
Adult↗
The effect of seminal plasma on gonadotrophin secretion by sheep pituitary cells in culture.
We tested the effect of seminal plasma fractions of pooled normozoospermic and azoospermic seminal plasma on secretion of LH by sheep pituitary cells in culture. From these experiments we conclude that there is activity in seminal plasma (molecular mass 10.000-80.000) which inhibits LH secretion. This activity is not steroid-mediated and is absent in azoospermic seminal plasma. These data support our thesis that LH secretion is not only controlled by testosterone but also by spermatogenesis per se.
Animals↗