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Biomedical subjects

C F Simpson

Publications and source records attributed to C F Simpson.

At least 91 records · Page 5Linked to original sources
PubMed1976

Hypercholeresis in turkeys following the ingestion of Crotalaria spectabilis seeds.

Young female turkeys received diets containing Crotalaria spectabilis seeds for 18 weeks. Mean values for total bile flow, biliary bile acid excretion, bile acid-dependent flow and bile acid-independent flow were significantly higher in crotalaria-fed turkeys than in controls. The hypercholeresis observed in crotalaria-fed birds involved both bile acid-dependent and bile acid-independent components of bile. Crotalaria-fed turkeys developed biliary hyperplasia. Liver weights were similar in the two groups. Since increases in 14C-erythritol clearances paralleled increases in total bile flow in crotalaria-fed turkeys (14C-erythritol bile to plasma ratios were similar in both groups), it was evident that the hypercholeresis in crotalaria-fed turkeys did not involve the ductal/ductular component of bile. Little or no ductal/ductular bile flow occurred in either group since total bile flow was equal to erythritol clearance and extrapolation to zero erythritol clearance yielded zero bile flow rates in both groups. Crotalaria-fed turkeys exhibited significantly higher biliary concentrations of chlorides (associated with lower sodium , potassium and bicarbonate concentrations) than did control birds. Validation of the use of 14C-erythritol clearance for the estimation of canalicular bile flow in turkeys was provided both by substantial decreases in bile to plasma 14C-erythritol concentration ratios following the injection of avian vaso-active intestinal peptide and the failure to demonstrate chromatographically the presence of radioactive metabolites of 14C-erythritol in plasma.

Animals↗
PubMed1976

The pathology associated with single and quadruple infections of hamsters with Dipetalonema viteae.

Two groups of five hamsters were each infected subcutaneously with infective larvae of Dipetalonema viteae; one group received single infections, and the second group received quadruple infections. A third group of five hamsters served as controls. Hamsters with primary and quadruple infections had cellular infiltrates in the liver and glomerular basement membrane thickening; these lesions were more extensive in the multiple than single infections. Hyperinfected hamsters also developed subcutaneous nodules. By histologic examination, it was seen that nodules were encapsulated abscesses which had a central, necrotic core, and were confined by a fibrous connective tissue capsule. The central portion of some nodules contained nondegenerated worms. The same area of other nodules contained dead worms, while still other nodules contained calcified worms or necrotic and calcified debris.

Abscess↗
PubMed1975

Psittacine herpesvirus infection resembling pacheco's parrot disease.

Herpesvirus was detected by electron microscopy in hepatocytes of psittacine birds that died at a Florida aviary. The virus was identified in hepatocytes of chick embryos and budgerigars that were given injections of liver suspensions from naturally infected psittacines. Infected hepatocytes had prominent intranuclear inclusions that contained naked nucleocapsids. Both naked and enveloped virions were seen in the cytoplasm of hepatocytes, and enveloped nucleocapsids occasionally were seen in the perinuclear cisternae and extracellularly. The experimental and spontaneous disease mimicked a condition in parrots described previously by Pacheco. The viral agent was classified as Herpesvirus on the bases of the character of the intranuclear inclusions, the size and conformation of the agent as determined by electron microscopy and filtration, and the sensitivity of the agent to ether.

Animals↗
PubMed1975

Biotin deficiency as a possible cause of swelling and ulceration of foot pads.

A high incidence of foot pad lesions and breast blisters were observed in broilers. Histological examination of foot pads indicated changes similar to those previously found when broilers were fed a biotin deficient diet. It is suggested that a marginal biotin deficiency in practical diets may be responsible for enlarged foot pads causing birds to rest on their breast resulting in increased breast blisters.

Animals↗
PubMed1975

Avian pox in Florida sandhill cranes.

Cutaneous elevations were present on the feet, legs and heads of four Florida sandhill cranes, Grus canadensis pratensis, (one free-living, three penreared birds). As a result of examination of the elevations by light- and electron microscopy, it was determined that the lesions were caused by poxvirus. This is the first record of pox in cranes in North America.

Animals↗
PubMed1975

Isolation and characterization of a herpesvirus from wild turkeys (Meleagris gallopavo osceola) in Florida.

Viral agents producing both a syncytial-type cytopathic effect and type A intranuclear inclusion bodies in vitro were isolated from the kidneys of five of 10 wild turkeys. A plaque assay system for viral infectivity was developed and used to characterize one of the wild turkey viruses (WTV). WTV replication was inhibited by 5-bromodeoxyuridine, indicating the virus contained DNA as its genetic material. Virus infectivity could be transferred only as viable whole cell preparations; one cycle of rapid freezing and thawing completely inactivated the virus. Typical herpes-like virions were found within the nuclei when cells infected with WTV were examined by electron microscopy. WTV had characteristics typical of the herpes group of viruses.

Animals↗
PubMed1975

Morphologic alterations of Anaplasma marginale in calves after treatment with oxytetracycline.

The morphologic features of Anaplasma marginale were determined after treatment of infected calves with oxytetracycline. By light microscopy, anaplasma bodies in erythrocytes of treated calves were enlarged and vacuolated, small and dense, or comma shaped. Several degenerated forms of anaplasma bodies were observed by electron microscopy. There was a blending of the 2 membranes surrounding initial bodies, aggregation of nucleoprotein at the periphery of the subunit, and vacuolation. A 2nd form of degeneration was coalescence of subunits in marginal bodies. A 3rd form of degeneration was unification of subunits of anaplasma bodies and clumping of nucleoprotein. A 4th form of degeneration was the persistence of an anaplasma body as a solitary, irregularly shaped mass containing electron-opaque clumps.

Anaplasma↗
PubMed1974

Lathyrism: a review.

Explore the source record for details and available documents.

Abnormalities, Drug-Induced↗
PubMed1974

Relationship of Ehrlichia canis-infected mononuclear cells to blood vessels of lungs.

The lung tissue of six dogs with ehrlichiosis and two control dogs was examined with the electron microscope. Mononuclear cells containing inclusions (morulae) of Ehrlichia canis were adhered at one or more sites to the luminal surfaces of endothelial cells of arterioles or capillaries by way of interdigitations or areas of adherence, or an endothelial cell-bound mononuclear cell was chained to another parasitized or nonparasitized mononuclear cell in the lumen. The bifurcation of arterioles was the most common site at which mononuclear cells clung to the endothelium. Cell-free bodies (morulae), enclosed by a single membrane, were present in the lumens of arterioles. Such cell-free bodies were swollen and vesiculated as compared with intracytoplasmic inclusions (morulae) in mononuclear cells.

Animals↗