This study examined the striatal dopamine system integrity and associated behavior in 5- to 7-year-old rhesus monkeys born from mothers that experienced stress and/or consumed moderate levels of alcohol during pregnancy. Thirty-one young adult rhesus monkeys were derived from females randomly assigned to one of four groups: (1) control group that consumed isocaloric sucrose solution throughout gestation; (2) stress group that experienced prenatal stress (10-min removal from home cage and exposure to three random loud noise bursts, gestational days 90 through 145); (3) alcohol group that consumed alcohol (0.6 g/kg/day) throughout gestation; or (4) combined alcohol plus stress group that received both treatments. The subjects were assessed for striatal dopamine system function using positron emission tomography (PET), in which the dopamine (DA)-rich striatum was evaluated in separate scans for the trapping of [(18)F]-Fallypride (FAL) and 6-[(18)F]fluoro-m-tyrosine (FMT) to assess dopamine D2 receptor binding potential (BP) and DA synthesis via dopa decarboxylase activity, respectively. Subjects were previously assessed for non-matching-to-sample (NMS) task acquisition, with ratings of behavioral inhibition, stereotypies, and activity made after each NMS testing session. Subjects from prenatal stress conditions (Groups 2 and 4) showed an increase in the ratio of striatal dopamine D2 receptor BP and DA synthesis compared to controls (Group 1). An increase in the radiotracer distribution volume ratios (DVRs), which is used to evaluate the balance between striatal DA synthesis and receptor availability, respectively, was significantly correlated with less behavioral inhibition. The latter supports a hypothesis linking striatal function to behavioral inhibitory control.

Analysis of Variance↗

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Calcitonin levels in thyroid-vein blood of man.

Radioimmunoassay determinations of calcitonin from blood samples obtained by selective venous catheterization have demonstrated a large peripheral to thyroid vein gradient for this hormone in both normocalcemic and hypercalcemic persons. These fingings indicate that in fasting humans the thyroid gland maintains peripheral levels of calcitonin by actively secreting the hormone, and are consistent with the suggestion that the role of plasma calcitonin is of physiologic significance.

Adult↗

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Calcitonin in thyroidectomized patients.

Hypothyroid patients with total or near-total thyroidectomy were found to have detectable immunoreactive calcitonin in the serum and urine. These findings suggest that human calcitonin may be secreted by extrathyroidal tissues.

Adult↗

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Limited calcitonin reserve in hyperparathyroidism.

A comparative study was made of the serum calcitonin levels of patients with hyperparathyroidism. The mean serum calcitonin of those with hyperparathyroidism did not differ significantly from normal persons (mean +/- SEM: 130 +/- 16 pg/ml vs 124 +/- 7 pg/ml, respectively.) Only 0.5% of patients with hyperparathyroidism had values exceeding the upper limits of normal. In contrast, the mean serum calcitonin of patients with hypercalcemia of nonparathyroid etiology was considerably higher than normal (354 +/- 75 pg/ml, p < 0.001)), and 41% exceeded the upper limits of normal. Calcium infusion induced less of an increase in serum calcitonin for patients with hyperparathyroidism than for normal persons. In addition, the diminished responsibility was also present postoperatively. These findings suggest that the prolonged hypercalcemia associated with hyperparathyroidism results in a decreased calcitonin reserve which may persist for unknown reasons. In the clinical evaluation of hypercalcemic patient, the finding of hypercalcitonemia is suggestive evidence against the diagnosis of hyperparathyroidism.

Calcitonin↗

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Serum calcitonin may be a marker for inhalation injury in burns.

One of the principal causes of death from burns is inhalation injury. The pulmonary neuroendocrine cell contains and secretes immunoreactive calcitonin (iCT), and, under the influence of various irritative stimuli, can be induced to secrete iCT in excess. A prospective study of serum iCT levels in 41 patients with burns was undertaken. Mean serum iCT levels were four times normal values at the time of admission and reached 31 times normal values by 24 hours after injury. These levels did not correlate specifically with burn size. However, serum iCT had a very strong positive correlation with mortality, and in addition, was highest in patients who died early after injury compared with those who died late after injury. Patients who were clinically suspected to have pulmonary injury and who died had markedly higher levels of iCT than those who survived. In addition, serum iCT correlated positively with the need for mechanical ventilation and the amount of pulmonary shunting. Although other factors may also play a role in hypercalcitoninemia, serum iCT may be an important marker for the presence of inhalation injury, as well as a prognostic indicator.

Adult↗

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Judgment processes for medication acceptance: self-reports and configural information use.

In the present study college student (N = 186) made judgments of the likelihood of accepting a medication for treatment of a hypothetically experienced clinical depression. Three types of information were manipulated: effectiveness of the medication for alleviating the symptoms of depression, potential side effects of the medication, and severity of depression hypothetically being experienced. The functional-measurement approach was used to examine whether self-reports are related to judgments and whether there is configurality in judging likelihood of medication acceptance. The results showed that subjects who reported different variables to be most important had predictably different effects of the variables in their judgments. There was also evidence for configural combination of information, and the nature of the configurality differed between subjects who reported Depression versus Side Effects as the most important type of information, respectively. The results show how the same information can be used differently by different individuals in making judgments, and that self-reports may reveal some important aspects of how information is used. The implications of the individual differences for health care consumer decision making and health care professionals' assessments and interventions are discussed.

Decision Making↗

PubMedDate not supplied

Self-paced RN refresher program: the North Carolina experience.

The need for refresher courses is a constant, as is the lack of courses, faculty, and geographically sufficient numbers of students. This article describes an approach that North Carolina nurses developed to address the need for RN refresher programs.

Curriculum↗