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C F Lindboe

Publications and source records attributed to C F Lindboe.

At least 37 records · Page 2Linked to original sources
PubMed1994

[Muscle tissue for diagnosis of neuromuscular diseases. Procedures of specimen taking, transport and preparation].

In this review we describe surgical methods for open muscle biopsy. In order to obtain optimal tissue quality, correct handling of the muscle specimens at all stages of the procedure is essential. A technologist who is familiar with the procedure should be present in the operating room. This is important to ensure that specimens for histochemical or biochemical studies are frozen immediately and specimens for electron microscopy are fixed without delay. We describe procedures for processing the specimens for cryostat sections, paraffin sections and electron microscopy, and a simple method for handling muscle specimens in local hospitals before transfer to a hospital with a neuropathological service.

Biopsy↗
PubMed1994

Immunoglobulin-containing cells in the colonic mucosa in patients with human intestinal spirochaetosis.

The relative proportions of cells containing the various classes of immunoglobulins in the colonic mucosa were determined in eight patients with human intestinal spirochaetosis (HIS) and in eight controls. All specimens were taken from colonic resections performed because of adenocarcinoma. None of the cases with HIS showed an inflammatory reaction in the mucosa as judged subjectively by light microscopy. Cases with HIS had smaller proportions of IgD- and IgE-positive cells and a larger proportion of IgA cells as compared with the controls, whereas the proportions of IgG and IgM cells were similar in the two groups. Taking into account the large individual variations in the proportions of immunoglobulins in both groups, our findings must be interpreted with caution. However, our results do not support the previous demonstration of increased percentages of IgE-positive cells in patients with HIS.

Adenocarcinoma↗
PubMed1993

[Intracranial tumors in children (under 15 years)].

Primary intracranial tumours develop in 30-35 Norwegian children each year. Of these tumours, astrocytomas are the most frequent, followed by medulloblastomas, oligoastrocytomas and ependymomas. In this article we give an overview of tumour classification, epidemiology, diagnosis, treatment and prognosis of intracranial tumours in children.

Adolescent↗
PubMed1993

[Intracranial tumors in adults (over 15 years)].

Primary intracranial tumours develop in 420 adult Norwegians each year. Of these tumours, gliomas are the most frequent, followed by meningiomas, pituitary adenomas and acoustic neurinomas. Glioblastomas represent more than 50% of the gliomas. Less than 10% of the patients with glioblastoma survive for two years, despite aggressive therapy (surgery, radiotherapy and chemotherapy). The prognosis for low grade gliomas is much better. In the case of meningiomas, 95% of the tumours are benign. The primary treatment for meningiomas is surgery. If surgery is impossible, radiosurgery should be considered. Pituitary adenomas are often hormone-secreting (e.g. prolactin, growth hormone, adrenocorticotrophic hormone). Many prolactinomas are treated with bromocriptine alone. The rest of the pituitary adenomas are treated by microsurgery and radiotherapy. The prognosis for patients with pituitary adenomas is good. Acoustic neurinomas, which in most cases are benign, are treated by microsurgery or radiosurgery. Postoperative morbidity due to cochlear nerve and facial nerve dysfunction is a problem. Brain metastases are far more frequent than primary intracranial tumours. Solitary metastases in patients with stable systemic disease should be treated by surgery or radiosurgery.

Adult↗
PubMed1993

[Gastrointestinal manifestations in neurofibromatosis].

Gastrointestinal involvement in neurofibromatosis occurs in three major forms: solitary neurogenic tumours, diffuse ganglioneuromatosis and visceral vasculopathy. The entire gastrointestinal tract may be affected. According to the literature, 10-25% of the patients with neurofibromatosis develop intestinal manifestations. However, the recorded incidence is probably too low, since many cases are undiagnosed. Two cases of large plexiform neurofibromas and diffuse ganglioneuromatosis of appendix and intestine are reported.

Adolescent↗
PubMed1993

Human intestinal spirochaetosis in mid-Norway. A retrospective histopathological study with clinical correlations.

Among 1205 mid-Norwegian patients who underwent colorectal biopsies during 1990, 30 cases (2.5%) with human intestinal spirochaetosis (HIS) were found. In only two cases were the spirochaetes mentioned in the biopsy reports. Cases with HIS showed a 7:3 male preponderance, but the mean age did not differ from that in the whole material. The spirochaetes were slightly more frequent in the rectum than in other parts of the large bowel. There was no indication of seasonal or geographical clustering of HIS and no association with occupation, use of certain drugs or underlying diseases. Most cases had HIS as the only positive biopsy finding, but the condition was also seen in connection with adenocarcinomas, Crohn's disease, and metaplastic and granulation polyps. The predominant symptoms of patients with HIS were faecal blood, diarrhoea, abdominal pain and constipation.

Adult↗
PubMed1992

Carcinosarcoma of prostate. Immunohistochemical and ultrastructural observations.

Carcinosarcoma of the prostate is a most uncommon disease, and only a few cases have been reported previously. We report the clinical and histopathologic findings in a seventy-three-year-old man with a prostatic carcinosarcoma. The mesenchymal component of the tumor was classified as malignant fibrous histiocytoma (MFH) by electron microscopy and immunohistochemical staining methods. This is to our knowledge the first case in which the stromal component of a prostatic carcinosarcoma has been classified as MFH.

Adenocarcinoma↗
PubMed1992

Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: case report.

A 27-year old male patient underwent surgery for a cerebellar ganglioglioma in which a pleomorphic xanthoastrocytoma constituted the gliomatous element. Neither radiation nor chemotherapy was administered. The patient was well for 12 years and then he suffered a recurrence and underwent a gross total resection. Histological examination revealed a ganglioglioma with thrombosed blood vessels, areas of tumor necrosis, and scattered mitoses. These anaplastic changes, which were restricted to the glial component of the tumor, may herald a more aggressive clinical course. However, 11 months after the second operation, there have been no signs of tumor recurrence.

Adult↗
PubMed1992

Hemorrhage in a highly vascularized subependymoma of the septum pellucidum: case report.

A 63-year-old man was admitted to our hospital because of loss of memory, disorientation, nausea, and urinary incontinence. Cerebral computed tomographic and magnetic resonance imaging scans revealed a tumor with intratumoral hemorrhage affecting the corpus callosum and the septum pellucidum. A partial resection of the tumor was performed, but the patient died the next day from an episode of bleeding. Postmortem examination revealed a highly vascularized subependymoma with acute bleeding in the tumor and in the surrounding brain parenchyma. The importance of considering a highly vascularized subependymoma is noted when a tumor related to the ventricular system is diagnosed.

Brain Neoplasms↗
PubMed1991

Topographic variations in the peripheral course of the greater occipital nerve. Autopsy study with clinical correlations.

The description of the peripheral course of the greater occipital nerve (GON) varies in the literature. An autopsy study was done on 20 cases without known headache problems. These findings showed a marked variation in the relation between the GON and nuchal muscles. The trapezius muscle was penetrated by the GON in 45% of cases, the semispinal muscle of the head was penetrated in 90% of cases, and the inferior oblique muscle of head was penetrated in 7.5% of cases. Macroscopic findings of possible compression were made in 11 cases (27.5%), indicating that nerve compression per se may be of minor importance since it seems to exist in the absence of headache.

Aged↗
PubMed1991

Wernicke's encephalopathy in an autopsy material obtained over a one-year period.

In a material comprising 279 consecutive autopsies obtained over a one-year period there were four cases of Wernicke's encephalopathy (WE), of which three were inactive (chronic) and one was active (acute). The latter was not related to chronic alcoholism. Our findings show that WE may be regularly present in a routine autopsy series. In only one case was WE suspected clinically and none of the cases revealed macroscopic brain changes indicative of WE. We therefore suggest that sections of the mammillary bodies should be taken routinely to detect all possible cases of WE.

Aged↗
PubMed1989

Wernicke's encephalopathy in non-alcoholics. An autopsy study.

In a 5-year autopsy material constituting 6,964 autopsies, there were 52 cases of Wernicke's encephalopathy of which 12 (23%) occurred in non-alcoholics. Among 18 cases with active (acute) disease, 7 cases (39%) were found in non-alcoholics. Only 4 cases of active Wernicke's disease were diagnosed clinically, all of them in alcoholics. The predominant clinical symptoms were disorientation and depressed levels of consciousness, whereas eye symptoms were recorded in only 3 cases. None of the non-alcoholics were given specific thiamine therapy, whereas some alcoholics received large doses of the vitamin as a routine procedure. However, the thiamine therapy was often instituted too late. It is concluded that active Wernicke's encephalopathy should be considered in all patients with prolonged malnutrition and that disorientation and depressed levels of consciousness may be the predominating symptoms of the disease. Even the slightest suspicion of Wernicke's encephalopathy should prompt immediate administration of large doses of thiamine parenterally.

Adult↗
PubMed1989

Fatal stroke in migraine: a case report with autopsy findings.

A 50-year-old woman with migraine was admitted to hospital shortly after having abruptly developed hemiparesis. CT scan revealed infarction in the territory of the right middle cerebral artery. Death ensued after three days due to cerebral edema with herniation. Autopsy revealed no pathologic findings in the heart or in the extra- or intracranial arteries. It is suggested that the fatal stroke may have resulted from arterial spasm caused by ergotamine overdosage and possibly complicated by thrombosis.

Brain↗
PubMed1989

Atrophy and sponginess of the mammillary bodies with neuronal sparing: not only inactive Wernicke's encephalopathy.

Two cases are reported in which old anoxic/ischemic damage to the Ammon's horns was associated with atrophy and sponginess of the mammillary bodies but with sparing of the neuronal perikarya. The lesions were unilateral in one case and bilateral in the other. The changes in the mammillary bodies closely resembled those seen in inactive Wernicke's encephalopathy but they were considered to be due to transneuronal atrophy following loss of hippocampal afferent fibres. Consequently, this condition may present a problem in diagnostic neuropathology. However, there was no reactive astrogliosis in these cases and this may serve to distinguish this condition from inactive Wernicke's encephalopathy in which gliosis is always present and often prominent.

Aged↗
PubMed1989

Pathogenesis of carotid thrombosis.

We histologically examined specimens from 11 patients with recent occluding thrombi at the carotid bifurcation to study local factors in the vessel wall that precipitated the thrombi. The area of stenosis of the vessel lumen was determined morphometrically. Severe atherosclerotic stenosis was frequent but was not a prerequisite for thrombus formation since specimens from almost one half of the patients had only moderate narrowing of the lumen (less than 60% stenosis). Specimens from three patients showed ulcerations, those from one showed intraplaque hemorrhage, and those from one massive plaque rupture, all of which were thought to be important in thrombogenesis. All such types of plaque complications may thus precipitate thrombi but no single complication was particularly predominant, and specimens from one half of the patients showed no complications at all. Screening of the carotid arteries for stenosis can therefore detect only one half of the individuals who ultimately will develop thrombosis, and the risk caused by plaque complications seems to be moderate in unselected materials.

Aged↗
PubMed1989

Fatalities in a stroke unit.

During the first 4 years of the CV unit the mortality rate among 464 patients was 5.2 per cent. The records of the 24 fatalities were reviewed. In the 10 patients submitted to autopsy the clinician's opinion of the cause of death was confirmed in 6 cases. In 4 cases autopsy revealed brain abscess, pulmonary embolism, acute myocardial infarction and pneumonia, respectively. Other significant findings not registered clinically were made in 4 cases. Twenty-three patients underwent a cerebral CT scan which showed positive findings in 19 cases. In one patient a brain abscess was misinterpreted as a brain infarction and in 2 other patients with a negative CT scan, autopsy revealed a small pontine and hemispheric infarction, respectively. Apart from the misdiagnosis of the brain abscess the accuracy of the CT scan was acceptable. Extracranial complications as a cause of or contributing to death in stroke patients are common. Prevention, early detection and treatment of these complications are important. The findings underscore the importance of autopsy in the evaluation of stroke patients.

Aged↗