Search PubMed⌕ Search

Biomedical subjects

C F Hollander

Publications and source records attributed to C F Hollander.

At least 37 records · Page 2Linked to original sources
PubMed1982

Early light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats.

The kidneys of 441 full-lifespan rats of Wistar (WAG/Rij) and Brown Norway (BN/Bi) strains and a Sprague-Dawley stock were evaluated histologically for chronic progressive nephrosis. Age- and strain-related susceptibility to chronic progressive nephrosis, in terms of degree of lifetime pathological change, was characterized for male and female WAG/Rij and BN/Bi and female Sprague-Dawley rats. Criteria for minimal chronic progressive nephrosis included thickening of the basement membrane of a glomerular capsule, cast formation, and atrophy of a segment of a proximal convolution with thickened basement membrane. The focal and segmental changes in increasing numbers of nephrons were criteria for severity of the disease. Sprague-Dawley rats showed comparatively rapid development of chronic progressive nephrosis during their second year of life, in contrast to the BN/Bi rats that were affected only slightly prior to 28 and 31 months of age, after which the disease progressed slowly. WAG/Rij rats appeared to assume an intermediate position between the other strains, the latter probably representing the extremes in the expression of this disease.

Aging↗
PubMed1982

A histopathological survey of aged Praomys (mastomys) natalensis.

This histopathological study shows that Mastomys develops a wide variety of neoplastic and nonneoplastic lesions with age. In comparing neoplastic lesions of Mastomys with those generally found in mice and rats, Mastomys is more or less unique with respect to the development of lymphoepithelial thymomas (40%), parathyroid adenomas (11%), prostatic adenocarcinomas (5%), and gastric carcinoids (4%) and the absence of brain, lung, and mammary tumors. Of the nonneoplastic lesions, prostatic (38%), thymic (12%) and parathyroid (11%) hyperplasia, and moderate to severe generalized degenerative joint disease (96%) occur rarely in mice and rats. Within the limits of this study, in which the age of the animals ranged from 18 to 39 months, a clear-cut age-related pattern was seldom found for most of the lesions occurring in Mastomys.

Aging↗
PubMed1982

[Gerodontology].

Explore the source record for details and available documents.

Adolescent↗
PubMed1980

Respiratory disease in rats associated with a filamentous bacterium: a preliminary report.

A naturally occurring, chronic disease of the respiratory tract was investigated from the time of its onset to completion of life-time studies in a colony of rats. The disease was characterized by peribronchial lymphoid cuffing, suppurative bronchitis, bronchiectasis and bronchial abscesses. Its onset in the colony occurred a few months after an epizootic of Sendai virus infection. Limited retrospective serological testing indicated that Mycoplasma pulmonis may have been present in the colony at that time and continued to persist throughout life in some rats in the colony. Although of uncertain significance, light and electron microscopy consistently demonstrated many filamentous bacteria between the cilia on respiratory epithelium and free in bronchial exudate in these cases. Attempts to culture this organism on artificial media were unsuccessful.

Animals↗
PubMed1979

Aortic body tumours and hyperplasia in the rat.

The histologic features of aortic body neoplasia, hyperplasia, and normal aortico-pulmonary paraganglia were described for a series of 56 rats of several strains. Argyrophilic cytoplasmic granules were demonstrated in chief cells of the aortic body lesions, and electron microscopic examination disclosed the presence of electron-dense, membrane-bound granules in these cells. In a series of ageing rats, hyperplasia and neoplasia of the aortico-pulmonary paraganglia occurred more frequently in female WAG/Rij rats than in males of that strain, and more frequently than in males and females of the BN/Bi strain or of the (WAG X BN)F1 hybrid. No apparent causal relationship to chronic hypoxia could be shown, in that no correlation between the development of aortic body neoplasia or hyperplasia and cardiopulmonary disease was found. Aortic body lesions did not appear to occur as part of a multiple endocrinopathy syndrome, although hyperplasia and neoplasia of various endocrine organs occurred relatively frequently in the WAG/Rij strain.

Aging↗
PubMed1978

Mortality of monkeys after exposure to fission neutrons and the effect of autologous bone marrow transplantation.

In order to assess the risk of exposure to ionizing radiation in man, and to evaluate the results of therapeutic measures, the mortality of rhesus monkeys irradiated with X-rays and fission neutrons and the effect of autologous bone marrow transplantation have been investigated. The LD50/30d values for X- and neutron-irradiated monkeys amount to 525 and 260 rad respectively, resulting in an r.b.e. of approximately 2 for the occurrence of the bone marrow syndrome. Protection of the animals by autologous bone marrow transplantation was observed up to doses of 860 rad of X-rays and 440 rad of fission neutrons. After both fission-neutron irradiation and X-irradiation in the lowest range of lethal doses, the bone marrow syndrome was found to occur without the concurrent incidence of the intestinal syndrome. The studies indicate that, for humans accidentally exposed to what would otherwise be lethal doses of fast neutrons, bone marrow transplantation may be beneficial.

Animals↗
PubMed1978

Idiopathic paraproteinaemia. I. Studies in an animal model--the ageing C57BL/KaLwRij mouse.

A search for a suitable animal model for studies on idiopathic paraproteinaemia showed that an age-dependent increase in the appearance of homogeneous immunoglobulins in serum was common to all of the seven mouse strains investigated to date. The highest frequency was found in C57Bl/KaLwRij mice. Further investigations in this strain demonstrated that, except for some quantitative differences, most of the features of human and C57BL Mouse idiopathic paraproteinaemia were essentially the same. No clear-cut correlation was found between the idiopathic paraproteinaemia and, in the old C57B1 mice, a rather frequently occurring reticulum cell sarcoma B and amyloidosis. The mouse idiopathic paraproteinaemia can be regarded as an analogue of the human idiopathic paraproteinaemia and therefore as a suitable model for further experimental studies.

Aging↗
PubMed1977

Incidence patterns of spontaneous tumors in BN/Bi rats.

The occurrence of tumors in 236 female and 74 male BN/Bi rats that were allowed to live out their normal lifespans was described. For most neoplasms, the risk of a rat dying with a specific tumor increased with age. Some tumors, however, had a peak incidence; therefore, animals surviving these periods were at less risk than were their younger cohorts. The number dying with metastatic cancers was greatest in females over 30 months of age. Unexpectedly, males had a peak risk period at 25-30 months, so that males that died in older age groups had less risk of dying with a metastatic tumor. Lesions were often multiple, even in rats dying at a young age. Surprisingly, the percent dead with multiple tumors did not increase significantly with age. Some animals in every age group died without a tumor, and the percentage without neoplasms did not decrease, even in the older age groups.

Adenoma, Islet Cell↗
PubMed1977

Comparison of growth characteristics of experimental tumours and derived cell cultures.

Cells from seven different rat tumours and a mouse sarcoma have been transplanted in syngeneic animals and were cultured in vitro. Tumours produced by inoculation of cultured cells in animals have been compared with the primary tumours. For the transplanted tumours, volume doubling times, T d, have been compared with doubling times, T d(cult), of cell numbers in cultures. Volume doubling times of the transplanted tumours generally decrease with increasing volume. At volumes of about 0-5 cm3, T d values range from 2-2 days to 10 days, while T d(cult) values ranged from 11 to 24 hr. A systematic correlation between T d and T d(cult) could not be established. During sequential transplantation of the tumours for many generations, as well as during continuous propagation of derived cell cultures, significant changes occurred which resulted in a decrease in the expression of differentiation characteristics in tumours.

Animals↗
PubMed1977

A naturally occurring epizootic caused by Sendai virus in breeding and aging rodent colonies. II. Infection in the rat.

Sendai virus infected a hysterectomy derived, barrier maintained breeding colony and a conventional aging rat colony. The virus produced seroconversion in the colonies followed by a 7-month period of decreasing titers. Clinical signs were absent during the months when titers were highest, and there was no increase in mortality, but multifocal interstitial pneumonia with perivascular and peribronchial cuffing by lymphocytes and plasma cells was present in rat lungs examined histologically. Such lesions were absent before the period of seroconversion. During the months of declining titers, the interstitial and perivascular lesions decreased in frequency and severity. The peribronchial lesions did not decrease, however, and were still present in many rats 7 months after the acute infection. Attempts to isolate the virus from weanling rats were unsuccessful.

Age Factors↗
PubMed1976

High incidence of spontaneous cervical and vaginal tumors in an inbred strain of Brown Norway rats (BN/Bi).

The incidence of spontaneously occurring tumors of the cervix and vagina was unusually high in an inbred strain of Brown Norway rats (BN/Bi). Fifty-four tumors were diagnosed in the cervixes or vaginas of 252 rats. Of the tumors, 7 were squamous cell carcinomas, 4 were leiomyomas, and the rest were sarcomas. These tumors were found in nearly 20% of all female rats that died naturally.

Animals↗
PubMed1976

Degenerative myelopathy in three strains of aging rats.

Spontaneous paresis and paralysis associated with degenerative spinal cord and spinal nerve root lesions occurred in three strains of rats used in studies of aging. Focal or segmental spinal cord lesions had mild to severe demyelination, loss of nerve axons, and lipid-filled gitter cells. The lesions were limited to the white matter and were most severe in the lateral and ventral funiculi. The nerve roots had cholesterol clefts, focal hemorrhage, and demyelination. Atrophy of the skeletal muscle probably was secondary to the cord lesions. Vertebral lesions that involved the spinal canal and vascular blood flow were found, which may explain pathogenesis.

Aging↗