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Biomedical subjects

C F George

Publications and source records attributed to C F George.

At least 163 records · Page 9Linked to original sources
PubMed1973

Assessment of selective beta-adrenoceptor blockade in man.

1. Selective antagonism of the cardiac beta(1)-adrenoceptors has been studied in normal human volunteers.2. Practolol and UK 6558 produced greater antagonism of the chronotropic and inotropic responses to i.v. isoprenaline than of the vasodilator response to either i.v. or intra-arterial isoprenaline. A third drug, M&B 17,803A, produced non-selective beta-adrenoceptor blockade in 2 of 3 subjects studied.3. Practolol, UK 6558 and M&B 17,803A, produced an attenuation of the responses to Valsalva's manoeuvre.4. A substantial reduction in blood pressure was seen in 3 of 4 normotensive subjects given UK 6558.

Adrenergic beta-Antagonists↗
PubMed1971

Resistance to -adrenoceptor stimulants (a possible explanation for the rise in ashtma deaths).

1. Resistance to isoprenaline has been produced in man and dog by prolonged exposure to the same, or the pharmacologically similar compounds, terbutaline and isoetharine.2. In guinea-pigs, pretreatment with these agents increases asthma mortality provoked by histamine which suggests that this resistance may reduce the effectiveness of endogenous sympathetic drive to the bronchi.3. Possible mechanisms by which the asthma death rate could be increased are discussed.4. It is suggested that a drug-induced cross resistance to endogenous sympathetic stimulation could have led to a deterioration of the asthmatic state in patients using the pressurized aerosols of sympathomimetic bronchodilators and that this might account for the rise in asthma death rate.

Adrenergic beta-Agonists↗