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Biomedical subjects

C F Claussen

Publications and source records attributed to C F Claussen.

At least 19 recordsLinked to original sources
PubMed1992

Plastic properties of the vestibulo-ocular reflex in olivo-ponto-cerebellar atrophy.

Disorders in vestibulo-ocular functions were studied in 4 patients with olivo-ponto-cerebellar atrophy (OPCA). The phenomenon of habituation, considered as a plastic property of the vestibulo-ocular reflex (VOR), was explored with a behavioural paradigm in these patients. When subjected to the habituation paradigm all patients presented a modified response opposite to that observed in normal subjects. The role played by the cerebellum in relation to VOR plasticity--well known in different experimental models--is analyzed. The hypothesis of a modification of the cerebellum's inhibitory action on vestibular nuclei neurons is put forward to explain the inversion of the VOR habituation phenomenon in these patients.

Adult↗
PubMed1991

Cranio-corpo-graphy. A neurootological screening test.

Cranio-corpo-graphy affords a photographic representation of the patient's "radar-like" movement patterns as he performs the standing (Unterberger, Fukuda) and stepping (Romberg) tests. Of the various parameters used for analysis, a wide angular deviation, i.e., where the patient deflects more than circa 60 degrees away from the sagittal axis, is taken to signify a peripheral dysfunction, usually involving the side of deviation. In addition, broad lateral sway values and standing tests sways suggest a central pathology. In this study, three data banks were created. One consisting of 500 patients tested in our department over the last ten years, all showing a normal cranio-corpo-graphic pattern; the second made up of 500 patients showing a clear peripheral pattern, i.e., abnormal angular deviation with normal sway values and the third (650 patients) with a typical central disturbance, i.e. a broad lateral sway. These groups were then submitted to a detailed statistical analysis.

Adult↗
PubMed1989

The treatment of minocycline-induced brainstem vertigo by the combined administration of piracetam and ergotoxin.

Two randomized studies to test the efficacy of a combination of Piracetam and Ergotoxin on the destabilized brainstem are reported. In the first study, a pharmacological model using Minocycline is employed. A follow-up clinical study analysed the effect of the preparation in 5 patients suffering from vertigo and other related complaints. It was seen that there was a significant improvement in the nystagmus profiles of the pharmacological model volunteers. Similarly, the patient group showed a marked improvement in symptoms, and in orientation capability as tested by Cranio-Corpo-Graphy.

Adult↗
PubMed1989

A computer analysis of typical CCG patterns in 1,021 neuro-otological patients.

A set of 1,021 patients who were investigated at our Department over the last few years was investigated in this study. Each patient underwent Cranio-Corpo-Graphy, and other related investigations. The patients' CCG's were quantified using a specially developed computer scanning method, and a computerized spreadsheet databank was thus created. Also included in the study were their clinical profiles, as charted using the NODEC III questionnaire. The isolation and comparison of various data subsets enables us to draw broad correlations between clinical and CCG findings, and permits us to establish 'normal values' for various parameters. It is seen that cranio-corpography is a reliable screening method for the topodiagnosis of vertigo.

Adult↗
PubMed1988

[Antivertiginous action of vitamin B 6 on experimental minocycline-induced vertigo in man].

By means of a former investigation it has been proved equilibriometrically that the application of 7 X 100 mg minocycline may induce a central equilibrium dysregulation of the brainstem type. It was the purpose of this study to further assure that the minocycline induced brainstem vertigo is due to a destabilization of a supervisory gamma-aminobutyric acid (GABA)ergic loop from the archeocerebellum upon the pontomedullary vestibular regulating pathways. As it is pharmacologically known that pyridoxine is essential for the synthesis of GABA, an inhibitory CNS neurotransmitter, 2 separate double blind trials on 20 healthy young persons each were carried out after the intake of 7 X 100 mg minocycline during 3 days with and without 7 X 40 mg pyridoxine simultaneously. These trials were checked against an additional placebo or initial non drug investigation. In all the 40 test persons it could be proved that the amount of vertigo and nausea symptoms was increased significantly due to the application of minocycline only. However, when combining minocycline with vitamin B 6, the vertigo and nausea symptoms as well as the nystagmus signs from the monaural and the binaural vestibular ocular tests as well as the vestibular spinal signs from the craniocorpography recordings of the stepping and the standing procedures were remarkably reduced. There were no statistical differences between the initial or placebo trials versus the trials with a combination of minocycline with vitamin B 6. The same holds for the vestibular vegetative reactions, measured by the simultaneous electrocardiography during the vestibular tests. All the equilibriometric tests applied showed a significant destabilization under the influence of a pure minocycline loading.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

[Equilibriometric measurements of central vestibular dysregulation following administration of minocycline].

An equilibriometric study has been performed on 20 healthy young women before and after the intake of 7 times 100 mg minocycline during 3 days. A systematic neurootological equilibriometry was performed analyzing the vestibular ocular, the vestibular spinal, the retino-ocular and the spontaneous nystagmus pathways. The results demonstrate that the tetracycline minocycline provokes a ponto-medullary liberation of the central vestibular regulating mechanisms. The central vestibular disinhibition could be exhibited by the monaurally elicited vestibular ocular nystagmus as well as by the radar image like cranio-corpography recordings of the head and body movements during a vestibular spinal stepping test. In parallel with these findings the participants of the study increasingly complained about vertigo of the rocking type, instability, malaise and wretching. Thus, the untoward side effects of a tetracycline like minocycline which is a frequent complaint of the patients, appears to be due to a central disinhibition of the vestibular equilibrium regulating mechanisms.

Adult↗
PubMed1986

[Diagnostic and practical value of craniocorpography in vertiginous syndromes].

Vertigo or dizziness and nausea are the subjective symptoms characteristic of vertiginous syndromes; nystagmus and oscillations of the head and body are the objective signs. Craniocorpography is a method for recording and measuring these oscillations rapidly and inexpensively. It provides easier diagnosis, follow up and measurement of a double-blind therapeutic effectiveness. In the trial author has demonstrated the beneficial effects of Ginkgo biloba Extract in vertiginous syndromes without obvious anatomical localisation.

Gait↗
PubMed1984

The combination of evoked responses with sensory-motor tests in practical neuro-otological diagnostics.

Vertigo, giddiness, tinnitus and hearing loss frequently occur in lower brainstem disorders as well as in inner ear diseases. To differentiate the inner ear disorders from central disease we use the impulse-traced craniocorpogram (ITCCG) for the vestibulo-spinal investigation and the acoustically evoked brainstem potentials as an objective indicator of central hearing dysfunction. Craniocorpography is a simple, objective and quantitative whole-body as well as intracorporal recording technique for head and body movements. It can be used as an office procedure, giving objective and quantitative results. It traces the head and shoulder movements with the help of light bulbs. It gives significant results and differentiates between peripheral and central vestibular lesions. The acoustically evoked brainstem potentials are read by a dual channel machine. The same applies to the acoustically evoked cortical potentials. The results are plotted in either case on the electrode-stimulus cross-chart. Thus they can be interpreted at a glance, similarly to the cranio-corpogram.

Brain Diseases↗
PubMed1984

[Combined computer-assisted neuro-otologic diagnosis of inner ear function in children].

Among 10 284 data files of neuro-otological patients of our neuro-otological data bank NODEC III, 8,6% pertain to children between 0 and 15 years of age. 350 (3,5%) of these are in the age group of 0-5 years, 261 (2,5%) in the group of 6-10 years and 267 (2,6%) in the group of 11-15 years. Modern inner ear functional diagnostic methods combine computerised neuro-otological audiometric as well as equilibriometric tests. Ranking of diagnostic applicability and efficiency comprises the following 6 steps of neuro-otological equilibriometric and audiometric tests: Child-adapted psychophysical hearing tests, Perrotatory nystagmus tests via electronystagmography, Postrotatory nystagmus tests via electronystagmography, Acoustic brain-stem evoked potentials ( ABEP ) with 2-channel averager, Caloric vestibular test via electronystagmography, Optokinetic nystagmus test via electronystagmography. It has been proved both clinically and statistically that the perrotatory as well as the postrotatory nystagmus recordings are accepted much better by the preschool children than the caloric test. The latter, however, provides us with superior topodiagnostic information. Acoustically evoked potentials usually require to be performed under sedation in preschool children. Automatic nystagmus evaluation via the computer system NYDIAC immediately yields all the important monocular nystagmus parameters and synoptical test charts, i.e. the butterfly calorigram . The computerbased neuro-otological equilibriometric as well as audiometric investigations should be performed by an experienced and specifically trained otolaryngologist. This diagnostic method promotes intense co-operation with colleagues in paediatrics, ophthalmology, neurology and traumatology.

Adolescent↗
PubMed1984

[Clinical experimental test and equilibrimetric measurements of the therapeutic action of a homeopathic drug consisting of ambra, cocculus, Conium and mineral oil in the diagnosis of vertigo and nausea].

This paper presents a study by means of a modern neurotological technique for investigating the action and the site of action of an antivertiginous drug. The sensory motor tests are able to discriminate the sites of the lesions in the equilibrium regulating system, i.e., peripheral vestibular system, lower brainstem regulating system, upper brainstem nystagmus generating system and supratentorial system. Acoustic brainstem evoked potentials add information. A sample of 40 vertigo and nausea patients was treated by a combined drug, containing cocculus D4 210 mg, conium D3 30 mg, ambra D6 30 mg, mineral oil D8 30 mg (Vertigo-heel). The patients received 3 tablets 3 times per day during 14 days. An initial investigation was performed just before starting the treatment. A second directly followed the therapy. By subjective self-rating 57.5% of the patients reported on an improvement after the intake of Vertigoheel. Statistical evaluations showed that the different vertigo and nausea symptoms as well as the trigger mechanisms of vertigo and nausea (i.e. getting up, turning the head or gazing aside), highly significantly improved due to the therapy. The objective sensory motor tests showed a highly significant improvement in the monaural caloric butterfly chart as well as in the vestibulospinal head and body sway. The site of the action of Vertigoheel is in the brainstem and the Medulla oblongata, especially the middle longitudinal fascicle (MLF). The localisation in this area can be stressed by the investigation with acoustically brainstem evoked potentials (ABEP).(ABSTRACT TRUNCATED AT 250 WORDS)

Antiemetics↗