Search PubMed⌕ Search

Biomedical subjects

C F Bolton

Publications and source records attributed to C F Bolton.

107 records · Page 6Linked to original sources
PubMed1979

Nerve and muscle biopsy: electrophysiology and morphology in polyneuropathy.

We correlated the results of biopsy of a muscle nerve, a sensory nerve, and tibialis anterior muscle with electrophysiologic studies in 13 patients with sensorimotor polyneuropathy and 6 patients with normal findings. There were significant correlations between teased fiber changes and conduction abnormalities in both muscle nerves and sensory nerves. The density of large myelinated fibers in the lateral fascicle of the deep peroneal (LFDP) nerve correlated significantly with both the motor unit estimate and compound action potential amplitude of the extensor digitorum brevis (EDB) muscle. Other characteristics of the EDB muscle compound action potential related poorly to teased fiber abnormalities. There was good correlation of needle electrode study of the EDB muscle with teased fiber analysis of the LFDP nerve and with the morphology of the tibialis anterior muscle in 75 percent of the cases, and only minor discrepancies in the remainder. These results emphasize the close relationship between certain structural and electrophysiologic changes in subacute and chronic polyneuropathy.

Adult↗
PubMed1978

Human pneumatic tourniquet paralysis.

A 47-year-old woman experienced loss of strength, sensation, and sweating distal to a pneumatic tourniquet applied to her upper arm during operation for a Dupuytren contracture. Electrophysiologic tests showed a severe conduction block of sensory and motor fibers, well localized to the presumed lower margin of the tourniquet, with little evidence of axonal degeneration. Reversal of block began at 5 weeks and was complete in 6 months, coincident with almost full clinical recovery. Sweating was absent before 5 weeks and then returned, accompanied by a causalgic syndrome that did not disappear until recovery from the electrophysiologic block. The findings in this case correspond closely to pneumatic tourniquet paralysis in baboons, the pathophysiology having been recently defined. The relationship of autonomic changes to the electrophysiologic block suggest a mechanism for this patient's causalgia.

Causalgia↗
PubMed1977

Periodic lateralized epileptiform discharges (PLED's) and nystagmus retractorius.

A 57-year-old diabetic woman presented with focal right-sided seizures and hyperglycemia. She later showed periodic lateralized epileptiform discharges (PLEDs), originating in the left hemisphere, which were temporally associated with nystagmus retractorius. It appears that the left hemisphere epileptiform activity diffusely excited brainstem structures via polysynaptic pathways to produce the nystagmus.

Diabetic Neuropathies↗
PubMed1976

Electrophysiologic changes in uremic neuropathy after successful renal transplantation.

The pattern of electrophysiologic abnormalities in uremic neuropathy was studied in 17 patients near the time of successful renal transplantation and for an average of 2 years (4 to 68 months) afterward. Initially, sensory and motor conduction velocities were reduced, distal latencies were lengthened, and evoked action potentials were reduced or dispersed. These abnormalities were most marked in clinically severe neuropathies and were consistent with the combined presence of axonal degeneration and segmental demyelination. Following transplantation, there was a sustained improvement in motor and sensory conduction velocities but less consistent improvement in evoked action potentials. In severe neuropathies, action potentials tended to remain reduced or absent. The results suggest that the main reason for improvement in the neuropathy is segmental remyelination, some fibers remaining degenerate in severe neuropathies. In four patients, late failure occurred in the transplanted kidney, which was accompanied by recurrence of neuropathy. In each patient, a second successful transplant effected improvement for a second time.

Action Potentials↗
PubMedDate not supplied

Neuropathies in the critical care unit.

Establishing the correct diagnosis of polyneuropathy is the key to better patient management. A more accurate prognosis can be determined in regard to, not only the problem of difficulty in weaning from the ventilator, but also the institution of physiotherapy and rehabilitation.

Biopsy↗