Analysis of developmentally homogeneous neural crest cell populations in vitro. I. Formation, morphology and differentiative behavior.
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Biomedical subjects
Publications and source records attributed to C Erickson.
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Immunization of mice with syngeneic mitomycin C-treated lymphoid tumor cells (EL-4 and S49A) conferred a high degree of immunity to transplantation with viable tumor cells in syngeneic animals. The development of this immunity was paralleled by the development of specific cell-mediated cytotoxicity; no anti-tumor antibodies could be detected in the immunized animals. In contrast to the high immunoprophylactic capacity of mitomycin C-treated cells, attempts to utilize these cells for immunotherapy were unsuccessful. Preliminary experiments did not reveal antigenic differences between mitomycin C-treated and untreated tumor cells.
Older nomenclature for non-Hodgkin malignant lymphoma has undergone revision to more accurate terminology based on cytology and histological pattern. Presentation of non-Hodgkin malignant lymphoma above the supraclavicular fossa demands through investigation to rule out occult disease in bone marrow and the intra-abdominal space. This is accomplished by appropriate clinical evaluation including lymphangiogram and exploratory laparotomy. However, the value of exploratory laparotomy for staging on increased survival rates in non-Hodgkin malignant lymphoma of the head and neck has not been established.
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