The intention of prescribing antibiotic treatment must be to achieve a concentration of the agent within the infected tissue well above th MIC or the bacteria causing the infection. As a basis for further clinical studies on antibiotic concentrations in maxillary sinus mucosa in humans, determinations of biologically active penicillin V in the mucous membranes of the maxillary sinus and the buccal mucose as well as in tissue fluids and tissue from subcutaneously implanted tissue cages in rabbits were made. Several experimental conditions were studied, with the purpose of establishing optimal conditions with regard to tissue sampling, blood contamination, prediffusion time, etc. Penicillin V was shown to have a good penetration into mucosal tissue in the rabbit, even at low perfusion pressure.

Animals↗

PubMedDate not supplied

Concentration of phenoxymethylpenicillin (pcV) in the mucous membrane of maxillary sinus in patients with and without sign of sinusitis.

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Administration, Oral↗

PubMedDate not supplied

Chronic maxillary sinusitis. Differential diagnosis and genesis.

By a careful ENT and oral examination of 111 patients with suspected chronic maxillary sinusitis, the diagnosis was verified in only 56% (62/111). In 29 of these 62 patients (47%) a relation to dental infections was found, periodontitis being as frequent as apical granulomas. In 61% of the patients, in whom the diagnosis chronic maxillary sinusitis could not be verified, dental infections and/or myofascial pain dysfunction syndrome (MPD) were the most common and likely cause of the symptoms. A careful oral examination including dental radiographs is thus important in patients with chronic maxillary sinusitis.

Adult↗

PubMedDate not supplied

On double-minutes and their origin in a benign human neoplasm, a mixed salivary gland tumour.

The cytogenetical observations in the first double-minute (DM)-positive benign neoplasm, a human pleomorphic adenoma, are described. It is suggested that in the present adenoma the first DM was formed from a structurally and/or functionally specialized segment of the long arm of a chromosome No 12. If so, the results also indicate a close relation between chromosome regions preferentially involved in structural rearrangements in a certain tumour type and chromosome regions with the potential capacity to become released and behave and function as DMs.

Adenoma, Pleomorphic↗