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Biomedical subjects

C Eggers

Publications and source records attributed to C Eggers.

116 records · Page 7Linked to original sources
PubMedDate not supplied

Conditioned blocking in patients with paranoid, non-paranoid psychosis or obsessive compulsive disorder: associations with symptoms, personality and monoamine metabolism.

Conditioned blocking (CB) refers to a delay in learning that a new stimulus, added during learning, has the same consequences as the conditioned stimulus already present. In animals such "learned inattention" depends on monoaminergic and limbic function and, thus, CB performance should be informative on selective information processing impairments found in subgroups of psychotic patients. Attenuated CB in acute schizophrenia has been reported to normalize rapidly. This study examines in young patients the specificity of CB performance to illness, and its associations with symptoms, personality traits and monoaminergic metabolic status. CB was attenuated in psychotic patients with non-paranoid symptoms (NP: n = 12, mean age 17 years) with respect to obsessive-compulsive (OCD: n = 13, mean age 16 years) and healthy subjects (CON, n = 29, mean age 18 years), but only a transient attenuation was observed in paranoid hallucinatory patients (PH: n = 14, mean age 19 years). Outgoing personality traits in CON and OCD subjects correlated with CB. In NP patients attenuated CB was associated with increasing neurotic lability. In PH patients CB correlated positively with "manic" but negatively with psychotic or neurotic scores. The severity of negative symptoms in psychosis and specific negative/positive symptoms in the NP/PH groups was associated with reduced CB. Increased dopamine activity (24-h urine samples) correlated positively with CB, but relative increases of noradrenaline metabolism in NP and serotonin metabolism in OCD patients interfered. In summary, marked psychotic or neurotic traits and some symptom-states were associated with reduced CB. The particular selective processing problems of NP patients may reflect inappropriate NA activity.

Adolescent↗
PubMedDate not supplied

Auditory event-related potential (ERP) and difference-wave topography in schizophrenic patients with/without active hallucinations and delusions: a comparison with young obsessive-compulsive disorder (OCD) and healthy subjects.

Event-related potentials (ERPS) in schizophrenics have been reported to show a reduced P3 on the left and less frontal mismatch negativity (MMN). But the specificity of such findings to component, its locus, the type of eliciting event and patient group remains uncertain. Hence, we examined ERP topography for P3, N2 and 3 precursor peaks according to stimulus (3-tone oddball), attention condition (diffuse/focused) and four types of difference-waves. We contrasted 24 healthy and 13 OCD subjects with schizophrenic patients with high versus low ratings of active delusions and hallucinations (12 paranoid-hallucinatory, PH; 12 nonparanoid, NP). P3 peaks were delayed and reduced in NP and PH groups. Midline peaks were usual in focused attention and a right bias in diffuse attention. P3 responses to irrelevant standards remained lateral in NP and small in OCD patients. All showed a small left and anterior bias in the P3-like peak in difference-waves. Mismatch negativity waveform (MMN) peaks shifted to the right in OCD, to both sides in PH and posteriorly in NP patients. Frontal processing negativity was biased to the left (early) in NP and to the right (late) in PH groups. Early peak topography reflected some later changes (e.g. PH and NP groups; P1-like peak, right bias absent; N1-like peak depressed and widely distributed; NP group, P2-like peak smaller on the left). In OCD patients, peak latencies were topographically undifferentiated (P1, P2) or delayed (N2). The OCD group showed an unusual regional allocation of processing effort. Before 200 ms frontocentral activity was more widespread in Ph and NP groups. Lateralization of negativity in target- and nontarget-derived difference-waves may reflect differential disruption of the frontal-temporal dialogue in registering important vs unimportant features. NP patients, in particular, treated irrelevant stimuli anomalously.

Adolescent↗
PubMedDate not supplied

[The importance of the transitional object for the psychological development of the child].

This study addresses the question whether children taken for treatment to a psychiatric hospital for children and adolescents differ from other, not noticeably disturbed children in their use of a transitional object. Parents of mentally disturbed children between six and eight years of age were interviewed about the transitional objects used by their children. The control group was made up of children of corresponding ages from an ordinary nursery school. Based on the extant literature, the concept of "transitional object" is described and defined. Twenty two research hypotheses were formed and subjected to statistical tests. As the main result concerning the research question it emerged that the children suffering from psychiatrical disturbances needed a transitional object mainly in their fourth year of life, but to some extent even in their fifth and sixth year whereas the "healthy" children in the control group without noticeable disturbances used a transitional object mainly in their first and second years. It could be shown with statistical significance that psychiatrically disturbed children had a transitional object at a later age and for a longer period of time than healthy, undisturbed children.

Adaptation, Psychological↗
PubMedDate not supplied

[Parent counseling by the patient care and guidance team on a child psychiatry unit].

A psychoeducational approach of the nursing staff's work with parents is presented. By offering a family visit to the unit prior to admission, systematic preparation of the admission process, reflected interactions with parents during their visits, by parents' evenings and parents' weekends, the nursing team makes a distinct contribution to the families' treatments. Pros and cons are dealt with, concerning issues of professional self-image, goal planning of the team as a whole, structures of team conferences, and supervision. As to evaluation, some parameters (incidence of dismissals for reasons of discipline, withdrawal of children against medical advice, patients referred to care of public authorities after treatment) are discussed for their usefulness.

Child↗
PubMedDate not supplied

Cerebral toxoplasmosis in a patient with the acquired immunodeficiency syndrome presenting as obstructive hydrocephalus.

We report the case of an adult AIDS-patient with an unusual pattern of toxoplasmic encephalitis resembling the congenital form of the disease. Extensive exudative ependymitis and plexitis caused obstruction of internal CSF-pathways with rapid development of hydrocephalus. CT showed hydrocephalus and multifocal hypodense non-enhancing lesions. Direct microscopy of the CSF demonstrated Toxoplasma organisms.

AIDS-Related Opportunistic Infections↗